- !"#$%&'(
$)* +*,!!
- Why study proteins ?
- -
**
- +./0*
* .0* => 00*
)0. ( 00 #12** 3(
Why study protein loops?
- +*4**(Pauling, 1951)
1 &*5** ##(/ 61α *01β 1 * /0## 0*78(
- *9*).**/
*:*(Benner, 1998) 9;
- */(Fernandez, 2004)
Camproux et al., 2004
#5 +0<5*
6&%..5 /
- =5
- =**
B V
#*
#8./4-
#0.
#**8./->
!" #$%&# " '( )" %% *" '(# +" ,##- " '( ." /'(0#%-
/4?7@@*
- 06&%*
- *..58*
*
12 12#$%� 555536'( 17 %%4534 555555555'(# 1#,##- 4555555553'( 12 18& 1 /'(0#%-&0170%6455555 55555555555',0#6&2 1 19%� 5'(0#&112 1##&/4345:
44?&0* A?3B*5
- 6&%
- Method
- #5*5**1<*@ @*9%
**( (Sander & al., 2006)
( ) [ ] ( ) ( )
w k L w N E
Np i i
µ × + − =
=1
1
- )1*1<*@ /
1 C*/ 1 D)(/