TEAM TU-EINDHOVEN
MRI AND BACTERIA AS DIAGNOSTIC TOOLS
THE ROAD TO OUR SOLUTION MRI scan of latter stages of brain cancer Photograph by Zephyr/Science Photo Library TUMOR IMAGING 2007 National Geographic Society
CHEMICAL EXCHANGE SATURATION TRANSFER (CEST) ORGANIC CONTRAST AGENTS
CHEMICAL EXCHANGE SATURATION TRANSFER (CEST) ORGANIC CONTRAST AGENTS
CHEMICAL EXCHANGE SATURATION TRANSFER (CEST) ORGANIC CONTRAST AGENTS
CHEMICAL EXCHANGE SATURATION TRANSFER (CEST) ORGANIC CONTRAST AGENTS
CHEMICAL EXCHANGE SATURATION TRANSFER (CEST) ORGANIC CONTRAST AGENTS
CHEMICAL EXCHANGE SATURATION TRANSFER (CEST) ORGANIC CONTRAST AGENTS
THE ROAD TO OUR SOLUTION BACTERIA BASED CANCER THERAPIES
TEAM TU-EINDHOVEN Our Solution
TEAM TU-EINDHOVEN Our Solution
TEAM TU-EINDHOVEN Our Solution Tumor mor Region gion (Hypox ypoxic c Environ vironme ment) t)
TEAM TU-EINDHOVEN Our Solution
TEAM TU-EINDHOVEN Detect the hypoxic environment The Sensor Contrast Generate contrast on an MRI scanner Agents Integrate the sensor and contrast agents The Chassis Safety Ensure patient safety
TEAM TU-EINDHOVEN The Sensor Contrast The Sensor The Chassis Safety Agents
TEAM TU-EINDHOVEN The Sensor Shift to low oxygen concentration Contrast The Sensor The Chassis Safety Agents
TEAM TU-EINDHOVEN The Sensor Contrast The Sensor The Chassis Safety Agents
TEAM TU-EINDHOVEN The Sensor Contrast The Sensor The Chassis Safety Agents
TEAM TU-EINDHOVEN The Sensor Contrast The Sensor The Chassis Safety Agents
TEAM TU-EINDHOVEN Contrast Agents • High Lysine Ratio • Practicality • Molecular Dynamics 1PJN Simulations Contrast Define The Sensor Safety The Chassis Agents chassis
TEAM TU-EINDHOVEN Contrast Agents THE SELECTION // 1ETF // 1G70 // 1PJN // Human Protamine 1 // Poly Arginine-Glycine // Poly Arginine-Serine // Poly Threonine-Lysine // Poly Lysine-Serine Contrast Define The Sensor Safety The Chassis Agents chassis
TEAM TU-EINDHOVEN Contrast Agents AEROBIC EXPRESSION NATIVE PROTEINS ARE CLEARLY EXPRESSED Contrast Define The Sensor Safety The Chassis Agents chassis
TEAM TU-EINDHOVEN Contrast Agents Contrast Define The Sensor Safety The Chassis Agents chassis
TEAM TU-EINDHOVEN Contrast Agents Contrast Define The Sensor Safety The Chassis Agents chassis
TEAM TU-EINDHOVEN The Chassis THE BIOBRICKS 19 NEW BIOBRICKS: - A FUNCTIONAL ANAEROBIC PROMOTER (BBa_K1123000) - 9 CEST PRODUCING PROTEINS (BBa_K1123013 – BBa_K1123021) - 9 COMPLETE TUMOR VISUALIZATION CONSTRUCTS (BBa_K1123001 – BBa_K1123009) Contrast The Sensor The Chassis Safety Agents
TEAM TU-EINDHOVEN The Safety Locks Outer ter AVOIDING AN IMMUNE Membrane Membrane SYSTEM RESPONSE Periplas Periplas m Cytop toplas las mic c Membr mbrane ane Illustration by David S. Goodsell, the Scripps Research Institute. Contrast Define The Sensor The Chassis Safety chassis Agents
TEAM TU-EINDHOVEN The Safety Locks THE KILL SWITCH Herpes Simplex Virus Thymidine Kinase- Prodrug Ganciclovir System Contrast Define The Sensor The Chassis Safety chassis Agents
TEAM TU-EINDHOVEN The Safety Locks THE KILL SWITCH MODEL Contrast Define The Sensor The Chassis Safety chassis Agents
BACTERIA AS DIAGNOSTIC TOOLS: WILL SOCIETY ACCEPT THE IDEA?
TEAM TU-EINDHOVEN Human Practices SYNTHETIC FACTS // Bringing the world of synthetic biology into everybody’s home. // Removing the reservations people have about synthetic biology by removing faulty data. // Collaborating and collecting data across the globe.
TEAM TU-EINDHOVEN Human Practices SYNTHETIC FACTS
TEAM TU-EINDHOVEN Human Practices SYNTHETIC FACTS 21 Initial Facts To Be Checked. 12 Main Topics . 10 Facts Are Officially Checked, Uploaded And Available.
TEAM TU-EINDHOVEN Human Practices SyntheticFacts .tue.nl
FINAL CONCLUSIONS
TEAM TU-EINDHOVEN We have established the foundations for a new bacterial application. “Synthetic Facts” will continue to give reliable and unbiased information.
TEAM TU-EINDHOVEN Acknowledgements Special Thanks To… TEAM PICTURE!!! // dr. Maarten Merkx // dr. ir. Tom de Greef // dr. ir. Natal van Riel // ir. Stijn Aper // Sagitta Peters MSc. // Industrial Designer Mariana Felix // ir. Stephanie Hectors // prof.dr. Klaas Nicolaij // dr. ir. Koen Pieterse
TEAM TU-EINDHOVEN
SUPPLEMENTAL SLIDES
TEAM TU-EINDHOVEN The Sensor Global design of the FNR-single and FNR-tandem promoter Reactions of the FNR-tandem promoter Contrast The Sensor The Chassis Safety Agents
TEAM TU-EINDHOVEN The Sensor Contrast The Sensor The Chassis Safety Agents
TEAM TU-EINDHOVEN The Sensor Contrast The Sensor The Chassis Safety Agents
TEAM TU-EINDHOVEN Contrast Agents CEST PRINCIPLES Contrast Define The Sensor Safety The Chassis Agents chassis
TEAM TU-EINDHOVEN The Chassis Tumor Escherichia Coli Targeting Environmental Sensor Detectable by CEST MRI Kill Switch Contrast Define The Chassis The Sensor Safety Agents chassis
TEAM TU-EINDHOVEN The Safety Locks AVOIDING AN IMMUNE SYSTEM RESPONSE K Capsule O-Antigen of LPS Polysacchar Smooth ide Surface Lipid A of Layer Lipopolysacch aride (LPS) Outer Membran Rough Rough e Peripla sm Cytoplasm ic Cytoplasm Membrane Journal of Endotoxin Research, Vol. 7, No. 3 , 2001 Contrast Define The Sensor The Chassis Safety chassis Agents
TEAM TU-EINDHOVEN The Safety Locks THE KILL SWITCH MODEL Contrast Define The Sensor The Chassis Safety chassis Agents
TEAM TU-EINDHOVEN The Safety Locks THE ALTERNATIVE KILL SWITCH Contrast Define The Sensor The Chassis Safety chassis Agents
TEAM TU-EINDHOVEN Modeling Overview
TEAM TU-EINDHOVEN Modeling: Decoy Sites
TEAM TU-EINDHOVEN Modeling: Integral Model 0 Decoy Sites 25 Decoy Sites 50 Decoy Sites 75 Decoy Sites 100 Decoy Sites 125 Decoy Sites 150 Decoy Sites 175 Decoy Sites 200 Decoy Sites
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