Pawel K. Olszewski, PhD pawel@waikato.ac.nz TEAM TEAM TEAM TEAM - - PowerPoint PPT Presentation

Pawel K. Olszewski, PhD

pawel@waikato.ac.nz

Pawel K. Olszewski, PhD Anica Klockars, PhD Kerry Allen, MSc

Doctoral students

Florence Herisson, MSc Sarah Gartner, MSc Oscar Klockars, MSc

Masters students

Chloe Brunton, BSc Fraser Aidney, BSc Crystal Gerring, BSc Ron Blaza, BSc Kathryn Laloli, BSc Kiriana Isgrove, BSc

TEAM TEAM TEAM TEAM TEAM TEAM TEAM TEAM TEAM TEAM

Appetite regulation

Organism Hunger, reward, anxiety, health/social status, age Food Energy, composition, taste and availability

Appetite regulation High-throughput animal models

hunger satiety reward stress boredom depression social context aversion

Appetite regulation High-throughput animal models

Ad libitum eating Meal (time-restricted; volume-restricted) Deprivation-induced eating Re-feeding Neophobia Taste aversion Motivation to obtain food Standard food Palatable food (single-nutrient; composite) Non-standard mixed diets (powdered, fluids) Healthy Obese/underweight Susceptible to diseases (strains, KOs)

Appetite regulation High-throughput animal models

In vivo pharmacology

Effect of administered nutrient on select behavioural and physiological parameters Effect of select drugs on intake of specific diets

Diet-induced behavioural, cognitive and physiological parameters

Memory Learning Sociability Locomotion Anxiety Depression Peripheral hormone levels

Diet-induced changes in expression of relevant genes

Effect of standard vs high-sugar diet intake on expression of hunger and satiety-related genes

Diet- or drug-induced changes in activity

• f specific brain areas

Effect of intake of anxiogenic versus anxiolytic diet on activity

• f AMY

Diet- or drug-induced changes in activity

• f specific brain areas

Effect of intake of high-fat versus high-sugar diet on activity of oxytocin neurons

High-fat High-sugar