On the future of probiotics research Dr. Olaf Larsen Probiota 2020, - PowerPoint PPT Presentation

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On the future of probiotics research Dr. Olaf Larsen Probiota 2020, Dublin Conflicts of interest Associate Professor @ Athena Institute, Vrije Universiteit Amsterdam (0.2 FTE) Senior Manager Science @ Yakult Nederland B.V. 2 Short

On the future of probiotics research Dr. Olaf Larsen Probiota 2020, Dublin
Conflicts of interest • Associate Professor @ Athena Institute, Vrije Universiteit Amsterdam (0.2 FTE) • Senior Manager Science @ Yakult Nederland B.V. 2
Short company profile 3
On the future of probiotics research 4
Responders & non-responders Kootte, Ruud S., et al. Cell metabolism 26.4 (2017): 611-619. 5
The challenges 1. A fair meta-analysis 2. A personalized approach Kootte, Ruud S., et al. Cell metabolism 26.4 (2017): 611-619. 6
1. The (partly) fair meta-analysis: strain-specificity Hill, Colin, et al. Nat Rev Gastroenterol Hepatol 11.8 (2014): 506-514. 7
1. The (truly) fair meta-analysis: product-specificity Flach, Koks, v.d. Waal, v.d. Nieuwboer, Claassen & Larsen, Critical reviews in food science and nutrition (2017): 1-15 8
2. The personalized approach (vs the black box approach) 9
2. Microbial guilds & graph theory External trigger Physiological response 10
2. Microbial guilds: graph theory 𝐸 = 𝐹 𝑛 11
2. Directed guilds of 5 species: heatmap ✓ 1.048.576 configurations already! ✓ 2.490.368 paths going from node 1 → node 5 Upon # nodes Larsen, et al. Scientific reports 9.1 (2019): 5558. 12
2. Weighted average density & efficiency ✓ Directed: more efficient ✓ Directed: more robust • Larsen & Claassen. Scientific reports 8.1 (2018): 1-5. Konopka, The ISME Journal (2009) 3, 1223 – 1230 • Larsen, et al. Scientific reports 9.1 (2019): 5558. 13
2. Ecological dimensions fecal transplant analogues Larsen, et al. Scientific reports 9.1 (2019): 5558. 14
The future of probiotics? 15
Probiotics in Europe: the future seems bright! Van der Geest, A. M., Flach, J., Claassen, E., Sijlmans, A. W., van de Burgwal, L. H. M., & Larsen, O. F. A. (2020) PharmaNutrition, 100178. 16
Acknowledgements: • • Eric Claassen, VU Anouk Sijlmans, VU • • Robert Jan Brummer, Örebro Universitet Mark vd Waal, VU • • Joop van Orsouw, Van Orsouw Design Peter vd Spek, Erasmus MC • • Joost Flach, VU Anton Koning, Erasmus MC • • Anne van der Geest, VU Yakult Questions? 17
On the future of probiotics research Dr. Olaf Larsen Probiota 2020, Dublin

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