On the future of probiotics research Dr. Olaf Larsen Probiota 2020, - PowerPoint PPT Presentation

On the future of probiotics research Dr. Olaf Larsen Probiota 2020, Dublin

Conflicts of interest • Associate Professor @ Athena Institute, Vrije Universiteit Amsterdam (0.2 FTE) • Senior Manager Science @ Yakult Nederland B.V. 2

Short company profile 3

On the future of probiotics research 4

Responders & non-responders Kootte, Ruud S., et al. Cell metabolism 26.4 (2017): 611-619. 5

The challenges 1. A fair meta-analysis 2. A personalized approach Kootte, Ruud S., et al. Cell metabolism 26.4 (2017): 611-619. 6

1. The (partly) fair meta-analysis: strain-specificity Hill, Colin, et al. Nat Rev Gastroenterol Hepatol 11.8 (2014): 506-514. 7

1. The (truly) fair meta-analysis: product-specificity Flach, Koks, v.d. Waal, v.d. Nieuwboer, Claassen & Larsen, Critical reviews in food science and nutrition (2017): 1-15 8

2. The personalized approach (vs the black box approach) 9

2. Microbial guilds & graph theory External trigger Physiological response 10

2. Microbial guilds: graph theory 𝐸 = 𝐹 𝑛 11

2. Directed guilds of 5 species: heatmap ✓ 1.048.576 configurations already! ✓ 2.490.368 paths going from node 1 → node 5 Upon # nodes Larsen, et al. Scientific reports 9.1 (2019): 5558. 12

2. Weighted average density & efficiency ✓ Directed: more efficient ✓ Directed: more robust • Larsen & Claassen. Scientific reports 8.1 (2018): 1-5. Konopka, The ISME Journal (2009) 3, 1223 – 1230 • Larsen, et al. Scientific reports 9.1 (2019): 5558. 13

2. Ecological dimensions fecal transplant analogues Larsen, et al. Scientific reports 9.1 (2019): 5558. 14

The future of probiotics? 15

Probiotics in Europe: the future seems bright! Van der Geest, A. M., Flach, J., Claassen, E., Sijlmans, A. W., van de Burgwal, L. H. M., & Larsen, O. F. A. (2020) PharmaNutrition, 100178. 16

Acknowledgements: • • Eric Claassen, VU Anouk Sijlmans, VU • • Robert Jan Brummer, Örebro Universitet Mark vd Waal, VU • • Joop van Orsouw, Van Orsouw Design Peter vd Spek, Erasmus MC • • Joost Flach, VU Anton Koning, Erasmus MC • • Anne van der Geest, VU Yakult Questions? 17

On the future of probiotics research Dr. Olaf Larsen Probiota 2020, Dublin

On the future of probiotics research Dr. Olaf Larsen Probiota 2020, - PowerPoint PPT Presentation

On the future of probiotics research Dr. Olaf Larsen Probiota 2020, Dublin Conflicts of interest Associate Professor @ Athena Institute, Vrije Universiteit Amsterdam (0.2 FTE) Senior Manager Science @ Yakult Nederland B.V. 2 Short

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