On the future of probiotics research Dr. Olaf Larsen Probiota 2020, - - PowerPoint PPT Presentation

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On the future of probiotics research Dr. Olaf Larsen Probiota 2020, - - PowerPoint PPT Presentation

Mar 17, 2023 487 likes β€’690 views

On the future of probiotics research Dr. Olaf Larsen Probiota 2020, Dublin Conflicts of interest Associate Professor @ Athena Institute, Vrije Universiteit Amsterdam (0.2 FTE) Senior Manager Science @ Yakult Nederland B.V. 2 Short

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On the future of probiotics research

  • Dr. Olaf Larsen

Probiota 2020, Dublin

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Conflicts of interest

  • Associate Professor @ Athena Institute, Vrije

Universiteit Amsterdam (0.2 FTE)

  • Senior Manager Science @ Yakult Nederland B.V.

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Short company profile

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On the future of probiotics research

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Responders & non-responders

Kootte, Ruud S., et al. Cell metabolism 26.4 (2017): 611-619.

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The challenges

Kootte, Ruud S., et al. Cell metabolism 26.4 (2017): 611-619.

  • 1. A fair meta-analysis
  • 2. A personalized approach
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  • 1. The (partly) fair meta-analysis: strain-specificity

Hill, Colin, et al. Nat Rev Gastroenterol Hepatol 11.8 (2014): 506-514.

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  • 1. The (truly) fair meta-analysis: product-specificity

Flach, Koks, v.d. Waal, v.d. Nieuwboer, Claassen & Larsen, Critical reviews in food science and nutrition (2017): 1-15

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  • 2. The personalized approach (vs the black box approach)
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  • 2. Microbial guilds & graph theory

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External trigger Physiological response

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  • 2. Microbial guilds: graph theory

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𝐸 = 𝐹 𝑛

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  • 2. Directed guilds of 5 species: heatmap

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βœ“ 1.048.576 configurations already! βœ“ 2.490.368 paths going from node 1 β†’ node 5 Upon # nodes

Larsen, et al. Scientific reports 9.1 (2019): 5558.

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  • 2. Weighted average density & efficiency

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βœ“ Directed: more efficient βœ“ Directed: more robust

  • Larsen & Claassen. Scientific reports 8.1 (2018): 1-5.
  • Larsen, et al. Scientific reports 9.1 (2019): 5558.

Konopka, The ISME Journal (2009) 3, 1223–1230

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  • 2. Ecological dimensions fecal transplant analogues

Larsen, et al. Scientific reports 9.1 (2019): 5558.

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The future of probiotics?

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Probiotics in Europe: the future seems bright!

Van der Geest, A. M., Flach, J., Claassen, E., Sijlmans, A. W., van de Burgwal, L. H. M., & Larsen, O. F. A. (2020) PharmaNutrition, 100178.

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Acknowledgements:

  • Eric Claassen, VU
  • Robert Jan Brummer, Γ–rebro Universitet
  • Joop van Orsouw, Van Orsouw Design
  • Joost Flach, VU
  • Anne van der Geest, VU
  • Anouk Sijlmans, VU
  • Mark vd Waal, VU
  • Peter vd Spek, Erasmus MC
  • Anton Koning, Erasmus MC
  • Yakult

Questions?

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On the future of probiotics research

  • Dr. Olaf Larsen

Probiota 2020, Dublin