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Albumin
IgG
Blood: 5 L.
IgG and albumin constitute 80-90%
- f the total protein pool in blood
IgG and albumin constitute 80-90% of the total protein pool in blood - - PowerPoint PPT Presentation
IgG and albumin constitute 80-90% of the total protein pool in blood - - PowerPoint PPT Presentation
IgG and albumin constitute 80-90% of the total protein pool in blood Albumin IgG Blood: 5 L. In 1993 my group (published in Nature) and also patented engineered antibodies with increased ability to kill target cells. More potent magic
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In 1993 my group (published in Nature) and also patented engineered antibodies with increased ability to kill target cells.
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4
NATURE|Vol 446|26 April 2007
More potent «magic bullets»
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FE.Johansen
O.Bakke
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Vision Statement
”CIR identifies and investigates novel mechanisms of immune dysregulation to advance the development of therapeutics for immune-mediated diseases”
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A culture for innovation
Geir Åge Løset Agnete Fredriksen Ole Henrik Brekke Jan Terje Andersen
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IgD (3) Lipoprotein (4) Fibrinogen (4) Haptoglobin (4) IgM (5) IgA (5) Transferrin (8) Albumin IgG1 IgG3 (7)
Serum half life
Half life in days (T1/2) 20 15 10 5
Struck by lightening
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Antibody binding Albumin binding A receptor in cells lining blood vessels save both IgG and albumin from degradation.
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Albumin drug
Idea: Design of ”super”-ALBUMIN
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Reduced frequency of dosing and toxicity
Drug
Level of drug in blood Level of drug in blood Time (days)
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Basic research Preclinical testing Production Therapy
Long serum half life = reduced dose + reduced dosing frequency + reduced toxicity + better compliance
Albumedix
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Albumin drug Albumin gene
Idea: Design of ”super”-ALBUMIN
Monthly injections may well be enough
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