IgG and albumin constitute 80-90% of the total protein pool in blood - PowerPoint PPT Presentation

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IgG and albumin constitute 80-90% of the total protein pool in blood Albumin IgG Blood: 5 L. In 1993 my group (published in Nature) and also patented engineered antibodies with increased ability to kill target cells. More potent magic

IgG and albumin constitute 80-90% of the total protein pool in blood Albumin IgG Blood: 5 L.
In 1993 my group (published in Nature) and also patented engineered antibodies with increased ability to kill target cells.
More potent «magic bullets» NATURE|Vol 446|26 April 2007 4
FE.Johansen O.Bakke
Vision Statement ”CIR identifies and investigates novel mechanisms of immune dysregulation to advance the development of therapeutics for immune-mediated diseases”
A culture for innovation Agnete Fredriksen Jan Terje Andersen Ole Henrik Brekke Geir Åge Løset
Serum half life Albumin Struck by lightening IgG1 20 15 Half life in days (T1/2) 10 Transferrin (8) IgG3 (7) 5 IgM (5) IgA (5) Lipoprotein (4) Fibrinogen (4) Haptoglobin (4) IgD (3) 0
Albumin Antibody binding binding A receptor in cells lining blood vessels save both IgG and albumin from degradation.
Idea: Design of ”super”-ALBUMIN drug Albumin
Reduced frequency of dosing and toxicity Drug Level of drug in blood Level of drug in blood Time (days)
Albumedix Basic research Preclinical testing Production Therapy Long serum half life = reduced dose + reduced dosing frequency + reduced toxicity + better compliance
Idea: Design of ”super”-ALBUMIN Albumin gene drug Albumin Monthly injections may well be enough

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