Fiocruz intramural INOVA program to accelerate science and - - PowerPoint PPT Presentation

Fiocruz intramural INOVA program to accelerate science and technology for health.

Oswaldo Cruz

The fight against smallpox, bubonic plague and yellow fever

Scientific and technological knowledge applied to public health

1900 - Founding

• f the Serotherapy

Institute of Rio de Janeiro in May 25 th.

Carlos Chagas, at the center, and members of the expedition. São Gabriel, Rio Negro (AM), 1913. Campaigns against Malaria: 1905 Itatinga (SP), 1907 Xerém (RJ), 1907 Lassance (MG).

Participation in the building of the Nation and State visions

VISITA PIERRE LANDOLT - MAI/2015

• problem driven
• vertical innovation chain
• wide scope of synergistic activities

Oswaldo Cruz Foundation

Research Education Innovation and Production Surveillance and Reference Services Health & Medical Care Environment and Health Promotion Information and Communication History of Science and Health Planning and Management

Fiocruz in Brazil

Pernambuco Mato Grosso do Sul Paraná Fiocruz Brasília Bahia Minas Gerais Amazonas Ceará Rio de Janeiro Rondônia Piauí

Fiocruz Nacional

Work force and productivity (nowadays)

• 12.000 professionals (MD, PhDs, nurses, technicians, pharmacists

social workers; historians; psychologists); 1.200 dedicated PhDs for Science and development

• Two hospitals;
• Three production plants (vaccines/immunobiologicals and

pharmaceuticals, Molecular Biology reagentes for DNA-based tests);

• Reference centers for infectious diseases surveillance;
• 2.500 papers in indexed Journals/year;

Fiocruz Innovation Ecosystem

Technical Cooperation Portuguese-speakers Countries (PCLP) Drug for Neglected Diseases Institute (DNDI) BRICS Pasteur Institute Net

Fio iocru ruz In Innovatio ion Ecosy system

Scale ale-up up Development Pre clin inic ical Clin inic ical l Tria ial l Prod

• ductio

ion

P H S Res esearch

• utbreak of Zika-associated microcephaly

9 Fiocruz main scientific areas - citations

InCites Dataset de 2012 a 2016

Fio Fiocru ruz In Innov

• vation Eco

cosystem

Scale ale-up up Development Pre clin inic ical Clin inic ical l Tria ial l

Prod

• ductio

ion

P H S

Res esearch

Yellow Fever Vaccine Production (1930s) Regular annual production for the Ministry of Health 25,000,000 doses, after 2016 outbreak new demand of 67,000,000

Amplia iação da da of

• fer

erta de de imunobioló lógicos: produção de até 120 milhões de frascos vacinas e biofármacos. Área total | 580

580 mil il m² m² Área construída | 178

178 mil il m²

Postos de trabalho | 1.5

1.500

Co Comple lexo In Industria ial l de Bio iotecnolo logia ia em Sa Saúde (CIBS IBS) ) – Sa Santa Cr Cruz (R (RJ) J)

Centro Integrado de Protótipos, , Biofármacos e Reativos para diagnóstico (CIP IPBR)

Área construída: 14.697,30 m²

Postos de trabalho: 300

300

FIOCRUZ; BIO-Manguinhos

31 products portfolio, among vacines, biopharmaceuticals and IVD Above 450 million doses delivered in the last 5 years 1.600 Employees

Instituto de Tecnologia em Fármacos (Farmanguinhos)

Área construída 40 40 mil l m² Funcionários 1.12 1.121 Capacidade instalada 6,5 6,5 bil bilhões s de de un unidades farm armacêuticas

Jacarepaguá I Complexo Tecnológico de Medicamentos-CTM

Nova ár área: Pl Planta de de Sín Síntese Qu Química (na (na UFR UFRJ): 7 7 mil il m² m²

• Produção de IFAs com

tecnologia nacional para doenças negligenciadas e crônico-degenerativas.

Port rtfoli lio Farmanguin inhos

Entregas 2016 (UFs): 200 milhões Entregas 2016 (UFs): 200 milhões

• Antibiotics
• Antiinflammatories
• Anti-infective
• Anti-ulcerative
• pain- killers
• Anti-malaria
• Tuberculostatics
• ART
• Cardiovascular, CNS, diabetes e hipertension.

Fiocruz África: Pro roje jeto Soc

• cie

iedade Moç

• çambicana de

e Med edicamentos – SMM S.A .A.

Fio iocru ruz Ceará

De Desenvolv lvimento cien científ ífico tecn ecnológi gico no

• Estado do
• Ce

Ceará - C& C&T e Saúde em es escala loc local l e e naci cional

Fio iocru ruz Paraná

Instituto de Biologia Molecular do Paraná (IBMP)

Ce Centro de e exc excel elência em em Bio Biotecnologia - Refe ferencia naci cional l em DT DT e pro rodução de e dia iagn gnósticos.

• Condições de saúde de importância epidemiológica ou

econômica para o Brasil, com destaque para doenças negligenciadas.

• Em andamento.

Ce Center for r Technolo logic ical Develo lopment in in Healt lth (C (CDTS) S)

Área construída

20 20 mil il m²

Innovation Program at Fiocruz – calls

Knowledge Knowl edge Talent s Products Ideas

Knowledge gaps that could improve better understanding of public Health. Knowledge talents - knowledge gaps for Young and bright researchers Innovative Project towards high maturity Project (with proof-of concept). Disruptive ideas, criativity novel applications and solution for Health.

736

Proposals submitted

35

Millions in funding

254

Approved

30

Research areas

34%

Approval

492

Reviewers

Innovation Program at Fiocruz – calls

Inova Ideas

Open submission for FIOCRUZ Community : 20% of the approved Project had a PI without a PhD degree

DOUTORADO 77% ESPECIALIZAÇÃO 7% MESTRADO 16%

Projetos Submetidos (%)

Base:262

54% 46% Inova - Gender

Submitted projects (%)

Highlights of research fields and technologies

Fields Technologies

Main axis of INOVA research

Digital Health: apps, games, eLearning, big data, geolocation New technologies for health: 3D printers, next generation vacines, and diagnostic tests, CRISPR/cas9, Omics. Neglected Diseases, cardiovascular, Neurodegenerative, and cancer: Better solutions: Treatment, surveillance, diagnosis

• New Brazilian Legal Framework of ST&I: FIOCRUZ experience
• Fiocruz's innovation policy integrates a set of principles, guidelines that contribute to the

strengthening of an innovation environment, aligned with Fiocruz's institutional policies plans according to the regulations approved at the VIII Internal Congress of Fiocruz.

Regulatory areas of the FIOCRUZ Innovation Policy

• Institutional action in the local, regional, national and international productive environment
• Promotion of scientific and technological entrepreneurship
• Provision of specialized technical services
• Permission for use by third parties of laboratories, equipment, human resources and intellectual capital
• Management of intellectual property and technology transfer
• Implementing partnerships for scientific research and technological development with public and private

institutions

• Internationalization of RD&I activities
• Participation, remuneration, removal and temporary leave for civil servants in PD & I activities
• Funding, managing and investing revenues from RD&I activities

Mechanisms of support for entrepreneurship

Support of novel enterprises

Internal and external projects Partnerships

• Development
• Technological services (facilities)
• Shared infrastructure
• Funding

SPINOFFS and STARTUPS

Pre- Incubation Formatting Ideas Incubation Creating and business strenghening

Types of entrepreuneurships supported

SPINOFFS companies constituted to explore some type

• f

knowledge

• r

intellectual property generated in the institution and that counts with the participation of at least one member of the community Fiocruz STARTUPS projects

• r

innovative nascent companies with potential to solve relevant health problems (including independent inventors)

To foster the culture of Innovation and entrepreneurship

Culture of Innovation and entrepreneurship

Training Events (workshops, courses) Dialogue with the Society

Creation of courses for researchers managers

Fares and business rounds awards, challenges hackatons, pitchs

Inova - Entrepreunership

Products knowledge Ideas

Innovation Portfolio FAR BIO MS Agreements, Contracts, partnerships Products + Services + Start-up, Spin off + accelerators New Innova calls + Pos-Doc

FIOCRUZ Innovation framework

OBRIGADO!

Thank you!