Contact: Sjaak Deckers, CEO +316 2249 0104 - - PowerPoint PPT Presentation

Confidential 2017 Dec 21 Slide 1 2018 Oct 20

Introduction Oct 2018

Contact:

Sjaak Deckers, CEO +316 2249 0104 sjaak.deckers@gtxmedical.com

Confidential 2017 Dec 21 Slide 2 2018 Oct 20

The Spinal Cord Injury Iceberg

Heart rate Pressure ulcers Blood pressure (hypo) Sleep Transpiration Infections Thermoregulation Antibiotics use Bladder physiology Bone density Bowel physiology Muscle mass Sexual function Spasticity Cardiovascular cap. Pain Dependence on others Hours daily routine Limitations in jobs, activities with kids, weekend activities, travel, etc

Wheelchair

Confidential 2017 Dec 21 Slide 3 2018 Oct 20

Photo: Herb Ritts

400’000 spinal cord injuries every year

Single patient lifetime healthcare cost is above 2 m$

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GTXmedical

Eindhov

• ven,

n, The Netherlan lands Lausan anne ne, Switze zerla rland

▪ Lausanne and Eindhoven ▪ Spin-off of research group at EPFL ▪ T eam started in 2016, now 40 employees ▪ Strong IP & licensing position ▪ Strong Investor support & solid financing (April 2016) ▪ Initial focus: paraplegic incomplete SCI patients

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Current: Lifelong severe disability

Car are e an and d reh ehab ab

▪ Training ▪ Learning to perform tasks ▪ Achieving best quality of life

Les esio ion

▪ Traffic accident ▪ Falls ▪ Bleeding

Live e with th the e di disab ability ility

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GTXmedical neuroprosthetic therapy (under development)

Spi pinal al Cord d Surge gery

▪ Place epidural lead + pulse generator ▪ T est muscle responses

Intensive ensive rehab b training ning

▪ Initial mapping phase ▪ 5mo, 5x/wk, 2h/d BWS training to promote neuroplasticity

Restor

• red

ed fu function tion

▪ Unsupervised use at home

Lesio ion

▪ Traffic accident ▪ Falls ▪ Bleeding

Confidential 2017 Dec 21 Slide 7 2018 Oct 20 Breakthroughs Prof Courtine, EPFL Nature 2018, 2016 Science 2015, 2012 Neuron 2016, 2015 Science Trans Med 2017, 2015, 2014 Nature Medicine 2016, 2012, 2008, 2007 Nature Neuroscience 2018, 2010, 2009 Cell 2014 The Lancet 2011

Based upon solid scientific understanding

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THE SPINAL CORD IS NOT ITS SERVANT

Confidential 2017 Dec 21 Slide 9 2018 Oct 20 2018 Feb 14

Implantation Mapping Rehabilitation Beyond Rehabilitation

Rehab with BWS Rehab without BWS Home Training + Home Use in daily life activities

Rehabilitation clinicians, Physiotherapists, Technician Neurosurgeon Neurologist

Functional mapping:

• define stimulation

functional outcome.

• define stimulation

configurations and training programs.

GTX medical

Developing a new therapy

Electrophysiologist, Technician

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Intensive body weight supported training activates neuroplasticity

Rysen 3D 3D

• vergrou
• und Body

Weight Support system for flexible rehab training. Partnering with MOTEK (Amst sterdam) am)

Confidential 2017 Dec 21 Slide 11 2018 Oct 20 2018 Feb 14

Implantation surgery of lead and INS

STIMO

Cervical Thoracic Lumbar Sacral

The electrode array is inserted via incision L1-L2 The stimulator is implanted in the belly

STIMO

Confidential 2017 Dec 21 Slide 12 2018 Oct 20 2018 Feb 14

Stimulating at the right time & place (Courtine, Nature 2018)

Muscle activi vity during gait cycle in healthy persons Corresp spon

• ndin

ing electrical rical recordin ings Neuromotor

• tor hotspot
• ts

s Muscle activi vity in SCI patient Muscle activi vity using stimulat lation ion Stimulation lation:

Confidential 2017 Dec 21 Slide 13 2018 Oct 20 2018 Feb 14

Simulations predict muscle mappings (Courtine, Nature 2018)

Muscle mappings and stimula lation ion pattern rns s in healthy person

• ns

Individu idualise alised simulati ation

• ns

s predict simila lar stimulat lation ion pattern rns s Targeted stimulat lation ion can separa rate between left hip flexi xion

• n and left ankle extension

ion

Confidential 2017 Dec 21 Slide 14 2018 Oct 20

Thank you