Chemical emical proces cesses ses an and separ arat atio ion - - PowerPoint PPT Presentation

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Chemical emical proces cesses ses an and separ arat atio ion - - PowerPoint PPT Presentation

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Chemical emical proces cesses ses an and separ arat atio ion n te techno hnology logy on a a micros croscale cale Mark Olde Riekerink Joint gathering of NL GUTS & PIN-NL, 9 April 2014 - Confidential - Outline Company

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Joint gathering of NL GUTS & PIN-NL, 9 April 2014

  • Confidential -

Mark Olde Riekerink

Chemical emical proces cesses ses an and separ arat atio ion n te techno hnology logy

  • n a

a micros croscale cale

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Outline

  • Company introduction
  • Chemical processes on a microscale
  • Continuous flow
  • Multistack reactor
  • Mesoreactor
  • Microreactor
  • Separation technologies on a microscale
  • Capillary electrophoresis (CE)
  • Dielectrophoresis (DEP)
  • Acoustophoresis
  • Passive microfluidics

confidential

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  • Confidential -

Micronit Microfluidics – Key Facts

  • Started in 1999 by Ronny van’t Oever & Micha Mulder

(Founders)

  • Location : Enschede, The Netherlands
  • University of Twente: Hot spot of micro- & nanotechnology
  • Annual turnover growth > 40%
  • > 700 customers in > 50 countries worldwide
  • About 50 employees and growing
  • Highly educated multi-disciplinary team
  • ISO 9001 certified, ISO 13485 (in 2014)
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We serve

leading brands in

analytic instrumentation and diagnostics globally

Our people serve world’s top 10

technical universities

  • Confidential -

International Customer Base

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MESA+, University of Twente

  • One of the largest micro-/nanotech groups worldwide
  • 500 people, 275 PhD’s and postdocs

2010 Nanolab

  • Infrastructure : >60 million euros
  • 1250 m2 cleanroom

2012 High Tech Factory (HTF)

  • Production facility for micro- and nanotech-based

companies/products

  • 13 cleanrooms, 20 laboratories, 46 offices

Enschede – Nanotechnology

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Micronit Cleanroom Facilities (HTF)

  • Photolithography processing and

Microstructuring of glass wafers

  • Confidential -
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  • Confidential -

Micronit – What We Can Offer

  • Developing, prototyping and high-volume

manufacturing of standard & custom Lab-on-a-Chip products

  • Microfluidic solutions for Life Sciences,

Chemistry and Industrial applications

  • Unique combination of microfluidics know-how,

semi-conductor, MEMS & micromachining capabilities

  • Market innovator powered by R&D department,

cleanroom facilities and intellectual property

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  • Confidential -

Core Business

MANUFACTURING

  • High-accuracy micromachining
  • Rapid prototyping
  • High-volume manufacturing capabilities

DEVELOPMENT PARTNER

  • Co-engineering
  • Design for manufacturing
  • Microfluidics know-how

RESEARCH TOOLS

  • Easy-to-use microfluidic kits to get started
  • Off-the-shelf standard microfluidic chip modules
  • Custom prototyping & low-volume manufacturing
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Broad Range of Microfluidic Solutions

Droplet Generator Chips Micromixers CE Chips Micro Reactor Chips Flow Cells Chip holders and connectors Fluidic PRO Prototyping Electrical connections Macro-to-Micro interfacing System integration and packaging

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Parallel droplet generation

  • Confidential -
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Advantages of Glass (I)

CHEMICAL INERTNESS

  • Solvents and water do not dissolve glass
  • Minimum interference with reaction or analysis

THERMAL STABILITY

  • Very well defined flat surface and mechanically stable
  • Glass is stable in time and has a very long shelf life

OPTICALLY CLEAR

  • Glass is optically superior, special types even in UV-range
  • Glass has a low (auto) fluorescence
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Advantages of Glass (II)

KNOWN MATERIAL

  • Glass is relatively easy to coat using traditional procedures
  • Easier to comply with regulations

NON-POROUS

  • Small molecules won’t diffuse into glass
  • No materials can diffuse out of the glass

SUITABLE FOR LOW- AND HIGH-VOLUME MANUFACTURING

  • Micromachining in glass in volume is very economical
  • Prototyping processes identical to manufacturing processes
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Outline

  • Company introduction
  • Chemical processes on a microscale
  • Continuous flow
  • Multistack reactor
  • Mesoreactor
  • Microreactor
  • Separation technologies on a microscale
  • Capillary electrophoresis (CE)
  • Dielectrophoresis (DEP)
  • Acoustophoresis
  • Passive microfluidics

confidential

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Development of continuous flow systems

confidential

Partnership Access2Flow:

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Chemical processes down to microscale

Laboratory Production Plant

Nano-Microliter

  • fast and cost effective

screening 1-10 ml

  • optimization via

modular approach 10-100 ml

  • production in

parallel reactors

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Multistack reactor (DSM)

  • 22 glass layers, of which 10 x 10 ml reaction channels
  • 11 cooling layers

Developed for and in cooperation with DSM

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Mesoreactor

  • Reactor volume 3 ml
  • 4 bonded glass layers
  • Highly efficient mixing structures
  • Confidential -
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FLOWID Plug & Produce Flow Chemistry

  • Confidential -

Switch from batch to continuous flow

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Microreactor Platform - Fluidic Connect Pro

Standard fluidic devices: (75x25mm) mixers, reactors, droplet generators, CE Reactor volume ~10 µl

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FlowStart Microreactor System

  • Smart, safe and clean chemistry
  • Accelerates the optimization of chemical processes

by automated microreactor technology

  • Batch-to-flow translations

The FlowStart microreactor system, developed in cooperation with Micronit Microfluidics

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Outline

  • Company introduction
  • Chemical processes on a microscale
  • Continuous flow
  • Multistack reactor
  • Mesoreactor
  • Microreactor
  • Separation technologies on a microscale
  • Capillary electrophoresis (CE)
  • Dielectrophoresis (DEP)
  • Acoustophoresis
  • Passive microfluidics

confidential

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Capillary electrophoresis (CE)

  • Separation of charged molecules (e.g. ions, DNA fragments) based on

their charge and mobility

  • Separation accuracy (resolution) dependent on channel length
  • Microfluidic applications:
  • DNA analysis
  • Blood analysis
  • Water analysis

confidential

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  • Confidential -

CE for Point-of-Care Applications (Lab-on-a-Chip)

Features Point-of-Care Lithium Chip

  • Glass chip with etched channels
  • Powderblasted access holes and

reservoirs

  • Sputtered metal electrodes
  • Dry dicing technique
  • 1 cm2 surface area
  • CE marked
  • On-chip reagents
  • Plastic packaging
  • Manufacturability in high

volume

  • Quality assured
  • Economic pricing (one-

time used chip)

  • > 100.000 devices/year

Source: www.medimate.com

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CE for Automated DNA Separation (Fingerprinting)

Sources: www.chem.agilent.com www.bio-rad.com www.perkinelmer.com www.shimadzu.com

Chip-based capillary gel electrophoresis is a proven technology for e.g. DNA analysis Forensics

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CE System for DNA Fingerprinting (conceptual)

  • Confidential -
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CE Lab-on-a-Chip Prototypes

  • Confidential -

Cartridge format USB stick format

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Dielectrophoresis (DEP) for cell manipulation/sorting

  • Confidential -
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Acoustophoresis for separation/concentration

  • Ultrasonic standing waves allow high-performance separation/

concentration of cells or particles

confidential

Source: www.cellcare.lth.se

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Microfluidic chip for cell separation/concentration

Yeast separation Blood cell separation from plasma