Biomolecular motors for directed assembly and hybrid devices Henry - - PowerPoint PPT Presentation

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Oct 27, 2023 249 likes •299 views

Biomolecular motors for directed assembly and hybrid devices Henry Hess Department of Materials Science and Engineering, University of Florida, Gainesville Movie: Microtubules polymerizing from tubulin protein subunits Kinesin moving a vesicle

SLIDE 1

Biomolecular motors for directed assembly and hybrid devices

Henry Hess

Department of Materials Science and Engineering, University of Florida, Gainesville Movie extracted from: Alain Viel, Robert A. Lue, and John Liebler/XVIVO “The inner life of a cell” BioVisions at Harvard University Movie: Microtubules polymerizing from tubulin protein subunits Kinesin moving a vesicle

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Baas, Microscopy Res. Techn. 48, 75

50 µm

Channel diameter: 50 µm vs. 500 nm Sample volume: 500 nL vs. 10 fL Flow velocity: 1 mm/s vs. 1 µm/s

Bio-Nanofluidics Smart dust sensor

Guiding Loading Control

SLIDE 3

Directed by: George Bachand Produced by: Sandia National Lab In collaboration with: Viola Vogel, ETH Zurich Banahalli Ratna, Naval Research Lab Peter Satir, A. Einstein College of Medicine Henry Hess, University of Florida With support from the DARPA Biomolecular Motors program Smart dust sensor for remote detection of chem/bio agents

SLIDE 4

Self-assembly driven by biomolecular motors complements “Molecular Robotics”

Nanorobotics using AFM: Molecular Robotics with motor proteins: Control Cost per assembly step

UNC Nanomanipulator

Thermally activated self-assembly:

Ned Seeman’s DNA cube

Cargo Loading Cargo Delivery

Sorting

Transporting Shuttle detail Assembly Cargo Delivery

Shuttle system

Molecular motors