About company carried out in the field of development of a special - - PowerPoint PPT Presentation

Products TM «BAIKAL legend»…..

To live longer…..

About company Sibpribor llc «Baikal legend» –stages of development

Company “Sibpribor llc” a registered company

established in Irkutsk 2008 .

From 2008 to 2013, scientific developments were

carried out in the field of development of a special technology for obtaining natural extracts.

In 2013, the first experimental production of the

company's basic products was launched: BioChaga and BioDihydroquercetin

In 2014 the products were registered under the

trademark "Baikal Legend" as a dietary supplements in Russia, the first sales started in pharmacies

Today the company is active both in Russia and in

the International markets – Hong Kong, Macau,

Singapore, Serbia, Romania, Slovenia.

Advantages of

• ur products

Biochaga and BioDihydroquercetin are obtained

from ecologically pure raw materials of the Baikal region.

The natural raw materials collected in Siberia

contain the maximum amount of biologically active substances due to the sharply continental climate of our region.

The unique technology (low temperatures and

deep vacuum) allows to extract biologically active components of natural raw materials as much and lossless as possible and preserve their natural form.

Special - super light - the consistency of product

(micro-dimension of the particles), ensures their high bioavailability

In the production process, aggressive chemicals

and high temperatures are not used

The final product is 100% active substance and

does not contain preservatives, dyes and ballast substances

Biochaga and Biodihydroquercetin are natural elixirs of longevity

• Slow down the aging process at the cellular level
• Slow down the development of many serious diseases

associated with aging

• Cardiovascular diseases

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Oncological diseases

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Type 2 diabetes mellitus and metabolic syndrome

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Alzheimer's disease

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Parkinson's disease

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Age dementia And improve the quality of life of the elderly

Biochaga-100% freeze-dried extract of birch mushroom chaga

Basic pharmacological actions

Detoxicant (removes toxins, heavy metals and

radionuclides)

Antioxidant (bind free radicals) Immunomodulator and adaptogen (activates nonspecific and

T-lymphocyte immune response)

Radioprotector (binds and displays radionuclides Anti-inflammatory and antispasmodic effect Cholagogue action Antibacterial and antiviral action (proven against influenza

virus, herpes

Hypoglycemic action An additional natural source of microelements: especially K

and Mg

The chemical composition of the Biochaga extract is unique and conditioned by a special production tech

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The content of water-soluble components is 92.5 ± 2.3%

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The ash content is 7.85 ± 0.31

Main BAS Chaga: Water-soluble intensely colored polyphenolic pigments (chromogens) 81 ± 2.68%

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Low molecular weight phenolic compounds (NPS) - 57.00 ± 1.48 mg / g

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High molecular weight phenolic compounds (VFS) (melano- carbohydrate complex) - 24.9 ± 1.2% The content of water-soluble polysaccharides (GRP) - 2.54 ± 0.06% The high content of microelements (especially K, Mg and Mn)

Molecular weight distribution of melanin (gelchromatography method) in Biochaga.

• The presence of one dominant polymer with a molecular mass of 15

kDa, which corresponds to early information on water-soluble melanin chaga (Olennikov et al., 2012) The distribution spectrum of melanin polymers:

• 3,4-dihydroxybenzoic acid (82%);
• 3,4-dimethoxybenzoic acid (8%);
• 3,5-dimethoxy-4-hydroxybenzoic acid (5%).
• 4-methoxybenzoic acid (3%);
• 4-hydroxybenzoic acid (2%);

Melanin BioChaga contains mainly fragments of pyrocatechol and pyrogallic types The high content of 3,4-dihydroxy fragments confirms in this melanin a high biological activity

Mechanisms of action of melanin chaga

Effectively suppress the peroxidation of polyunsaturated fatty

acids

Geroprotective activity: involved in DNA repair, prevent

single-stranded DNA breaks

Protect the body from extreme conditions, exposure to

carcinogens and mutagens

Prevent damage to biomembranes and oxidation of

glutathione

Depending on the conditions, they can be in the form of

phenoxy or semiquinone radicals and interact with oxidation products of xenobiotics and heavy metals

A unique property of melanin pigments is a stable free-radical

state and a high content of paramagnetic centers of carboxyl and carbonyl groups.

The main indicators of biological activity and efficiency of Biochaga

High antioxidant activity ▪

ORAC 1859 ± 042 µM TE / g

PROTECTION OF CELL COMPONENTS FROM LIPOPEROXIDATION ▪

Hydrophilic protection is high (IC50HYDRO, µg / ml - 32.6 ± 1.1)

▪

Lipophilic - medium - IC50LIPO, mcg / ml - 76.7 ± 3.0

High antiradical protection against organic and inorganic radicals ▪

Radical O2 • (superoxide radical) - 51.7 µg / ml

▪

Radical OH • (hydroxyl radical) - 82.3 µg / ml.

▪

The radical Cl. (Inorganic natural radical) - 252.16 ± 6.5 meq / g

A strong reducing agent, similar in activity to ascorbic acid and ionol Inactivates nitric oxide molecules and has anti-inflammatory properties

(nitric oxide binding - (NO) <500 mcg / ml).

INDICATIONS For Taking OF BIOCHAGA

PREVENTION AND AUXILIARY TREATMENT OF ONCOLOGICAL

DISEASES

AUXILIARY MEDIUM WITH SUGAR DIABETES (lowers blood

glucose level)

AUXILIARY MEDICINE IN THE TREATMENT OF GASTROINTESTINAL

TRACT (gastritis, peptic ulcer and duodenal ulcer, dyskinesia of the gallbladder hypomotor type, polyposis of the intestine, constipation)

CARDIOVASCULAR DISEASES AS AN ADDITIONAL SOURCE OF

POTASSIUM AND MAGNESIUM

USED AS IMMUNOMODULATOR AND ADAPTOGEN IN DURABLE AND

FREQUENTLY AFFECTED PEOPLE

POISONING OF HEAVY METALS RADIATION INFECTION

Mechanisms of action of chaga in cancer

• Influences through the central and peripheral nervous system due to the action of

the total complex of BAS (polyphenolic chromogenic complex - melanin, flavonoids, phytolectins).

• The specific effect of chaga on enzymatic and hematopoietic systems is expressed

in the removal of toxicosis, the restoration of the reactivity of the organism, the normalization of catalase and protease metabolism

• With prolonged admission, tumor growth slows down and its incidence toward

metastasis decreases Increases the defenses of the body and helps to isolate the tumor tissue, as a foreign body.

• There are data (MA Krotkina and MP Berezina (1959)) that under the influence of

chaga, a gradual resorption of tumors occurs with the preliminary appearance of micronecrosis and the encapsulation of tumor cells.

Clinical manifestations of the therapeutic effect of chaga in cancer patients

Reduction of tumor intoxication (nausea, vomiting, asthenia) Improving the quality of life (improves appetite, sleep, tones up Removal or reduction of pain syndrome Normalization of the physiological functions of the body Improves blood picture Increases life expectancy The processes of healing of surgical wounds are accelerated

Mechanism of immunomodulating and hypoglycemic activity of chaga

Immunomodulator

• Activation of a nonspecific immune response
• Correction of the number of immunoregulatory cells
• Normalization of cytotoxic activity of natural killers

and correction of immunodeficiency states HYPOGLYCEMIC ACTION Lectins are capable of reversibly binding carbohydrates in the blood and reducing the sugar content in the blood of diabetic patients (VF Korsun and VM Lakhtin (2004, 2007) Chromium, zinc, manganese - help reduce blood sugar levels

Radioprotective action Chaga (2002 experience on rats)

Reduction of the deposition of radionuclides (radioactive isotope strontium (90Sr) in the bone and soft tissues of rats

• An increase in the excretion of isotopes with urine by 33-35% (LN Rasina
• With prolonged gamma irradiation (up to 60 days) of mice, the

cryopreparations of chaga increased the life expectancy of animals by 1.6 times (the control group was 186 days, the group taking chaga-up to 305 days)

• Chaga prevented the development of leukopenia and promoted the

recovery of red bone marrow cells

• Chaga inhibited the peroxidation of blood lipids and increased the rate of

recovery of bone marrow cells in animals, which also indicates adaptogenic activity (AS Gavrilov et al., 2003).

The safety of Chaga extract

Chaga is well tolerated It does not have a toxic and irritating effect Well combined in therapy with other drugs, including With hormonal.

Complete safety in therapeutic doses is confirmed by numerous clinical trials, with continuous long-term use (EY Martynova, PK Bulatov 1961, 1966)

BioDihydroquercetin is a reference natural antioxidant from larch wood BIOFLAVONOID is a natural phenolic compound, a composition of 100% dihydroquercetin

BIODIHYDROQUERCETIN is a standard among antioxidants

Nobel Prize winner Linus Pauling said "... regular

taking of dihydroquercetin contributes to a real extension of human life for 20 to 25 years ..."

The antioxidant activity of dihydroquercetin

appears even at its concentrations of 0.0001 - 0.00001% with no mutagenic activity for a person.

Main pharmacological properties of BioDihydroquercetin

Antioxidant Capillaroprotector Cytoprotector

Immunomodulator

Immunomodulator Improves rheological

properties of blood

THERAPEUTIC EFFECTS OF BIODYHYDROQUERCETIN in cardiovascular diseases (An adjuvant)

Slowing the formation of an atherosclerotic plaque

Prevention of heart attack and stroke

Correction of conditions post-stroke periods IHD, including unstable angina Reduction of the level lipoproteins low density Improved myocardial conductivity Prevention of diffuse micro-ischemia and improvement of quality

• f microcirculation in the peripheral vascular bed

improved trophism and the effectiveness of myocardial

contraction, normalization of its excitability and conductivity.

Stabilizes cellular respiration. Improvement of blood microcirculation and its rheological

• parameters. Reduced resistance to movement of blood in

peripheral vessels .;

hypertonic disease;

BIODIHYDROQUERCETIN IN THE TREATMENT OF COMPLICATIONS OF SUGAR DIABETES

With diabetes, the level of oxidation is increased, which, along with the production of glycotoxins, leads to diabetic vascular damage

Diabetic cardiomyopathy and atherosclerosis Diabetic Nephropathy ✓

Cataract The defeat of the vessels of the fundus (blindness)

Diabetic foot ✓

Trophic foot ulcers

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Diabetic gangrene BIODIHYIDROQUERCETIN PREVENTs or SLOWS THEIR DEVELOPMENT

BIODIHYDROQUERCETIN HAS IMMUNOMODODULATING ACTION

Drugs reduce the production of cytotoxic superoxide anion

and normalize the activation of the subpopulation of active lymphocytes

Enhance the nonspecific immune response (phagocytosis)

by activating macrophages

DHA demonstrated a modulating effect on cytotoxic

lymphocytes and neutrophils

DHA increases the activation of T lymphocytes by

stimulating the production of interferons.

BIODihydroquercetin, due to its special production technology, has a special composition and unique properties

CHEMICAL COMPOSITION: Dihydroquercetin - 96.84 ± 2.03%

• Dihydrocampherol - a natural satellite of dihydroquercetin
• no more than 1%

High purity of substance BDQ

• Bioavailability BDQ - 74-76%.
• High antioxidant values of the molecule are due to the

special technology of obtaining BDQ – Total antioxidant potential (TAC) - 964.30 ± 38.57 gallic acid/g ORAC (Oxygen Radical Absorbance Capacity) Biodihydroquercetin - 27578 ± 717 мкМ TE/g

Pharmacological properties of BDQ

ANTI-INFLAMMATORY PROPERTIES

are higher than in diclofenac (83.9 and 64.3%, respectively)

MEMBRANO STABILIZING ACTION is

close to prednisolone (68.1% and 82.7%, respectively).

Advantages of BIODYHYDROQUERCETIN

High bioavailability High biological activity (antioxidant and antiradical) A special method of admission - sublingual - ensures the speed

• f delivery of the active substance to the bloodstream in an

unchanged form.

Enhanced antioxidant activity (the shape of the molecule is the

same as in larch wood)

Composition 100% Biodihydroquercetin It does not contain additional chemical additives, impurities and

ballast substances

The optimal single and daily dosage (70 mg) High Compliance - once a day

Joint application of BioChaga and BioDihydroquercetin

The direction of the action of BioChaga and BioDihydroquercetin is similar:

Prevention of oncological processes sugar diabetes

Cardiovascular diseases

Immunity cleaning body

They affect the different links of pathogenesis. JOINT USE OF THESE MEANS INCREASES FINAL THERAPEUTIC EFFECT