9/30/2015 FamilialAssociationofCanceroftheBreastandOvary& - - PDF document

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9/30/2015 FamilialAssociationofCanceroftheBreastandOvary& - - PDF document

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9/30/2015 FamilialAssociationofCanceroftheBreastandOvary& Kingpaperlinkedbreastcanceronchromosome17 Ovariancancerand

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9/30/2015 1

Dr.StevenA.NarodMD,FRCPC CanadaResearchChairinBreastCancer Director,FamilialBreastCancerResearchUnit,Women’sCollegeHospital Professor,UniversityofToronto

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Ovariancancerpatients Breastcancerpatients

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*+,- &' * . MRI 176 46.8% 134 59.8% PreventiveMastectomy 153 40.7% 93 41.5% PreventiveOophorectomy 284 75.5% 154 68.8% Tamoxifen chemoprevention 38 10.1% 30 13.4%

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''47"896 % ''47"896 Allsubjects 0.47(0.29&0.76)0.002 0.46(0.27&0.79) 0.005 BRCA1only BRCA2only 0.36(0.19&0.68) 0.002 0.70(0.32&1.52)0.36 0.38 (0.19&0.77)0.007 0.57(0.23&1.43)0.23 Ageofdiagnosis <50 ≥50 0.47(0.28&0.79)0.004 0.53(0.15&1.83)0.32 0.48(0.27&0.88) 0.02 0.29(0.15&2.03)0.29 Chemotherapy Yes No 0.38(0.21&0.70)0.002 0.67(0.29&1.53)0.34 0.38 (0.19&0.76)0.006 0.52(0.20&1.36)0.18 Stage I II 0.42(0.18&0.97) 0.04 0.50(0.28&0.90)0.02 0.32 (0.12&0.83)0.02 0.51(0.27&0.99)0.05 ER&status Negative Positive 0.06(0.01&0.41)0.005 0.71(0.36&1.39)0.31 0.07(0.01&0.51)0.009 0.76(0.32&1.78)0.53

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  • Predictors of Survival in BRCA1-Positive Breast Cancer Patients in Poland

Huzarski T,1 Byrski T,1 Gronwald J,1 Cybulski C,1 Oszurek O,1 Szwiec M,3 Gugała K,4 Stawicka M,5 Morawiec Z,6 Mierzwa T,7 Falco M, Janiszewska H,8 Kilar E,9 Marczyk E,10 Kozak-Klonowska B,11 Siołek M,11 Surdyka D,12 Wiśniowski R,13 Posmyk R,14 Domagała P,2 Sun P,15 Lubiński J,1 Narod SA15 and the Polish Breast Cancer Consortium

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0.40(0.09&1.77)0.23 1.15(0.42&3.18)0.78 1 0.34(0.07&1.67)0.18 0.42(0.14&1.28)0.13 Oophorectomypreventsovariancancerandbreastcancer Oophorectomyisadjuncttreatmentforbreastcancer Combinationofcis&platinumandoophorectomy? HRTsafeforunaffectedcarriers

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9/30/2015 7

EUROPE:

  • JanKlijn
  • SiranoushManoukian
  • DominiqueStoppa&

Lyonnet

  • BarbaraPasini
  • ChristianSinger
  • CatharinaAnneSpeiss
  • PalMoller

25

UNITED STATES:

  • FergusCouch
  • MaryDaly
  • SusanDomchek
  • CharisEng
  • JudyGarber
  • ClaudineIsaacs
  • BethKarlan
  • HenryLynch
  • WendyMcKinnon
  • SusanNeuhausen
  • KenOffit
  • Funmi Olopade
  • MarkRobson
  • HowardSaal
  • NadineTung
  • JeffreyWeitzel
  • MarieWood
  • DanaZakalik
  • KevinSweet
  • LeighaSenter
  • CarrieSnyder
  • TuyaPal

CANADA:

  • PeterAinsworth
  • Ab Chudley
  • AndreaEisen
  • WilliamFoulkes
  • ParvizGhadirian
  • DonnaGilchrist
  • EdLemire
  • BarryRosen
  • JoanneKotsopoulos
  • KellyMetcalfe
  • PingSun
  • SusanArmel
  • LouiseBordeleau
  • OphiraGinsburg
  • SeemaPanchal
  • AlettaPoll
  • WendyMeschino
  • GillianMitchell

POLAND:

  • JacekGronwald
  • JanLubinski
  • CezaryCybulski
  • TomaszHuzarski
  • TomaszByrski