WP19 WP19 PET FOR IN VIVO MONITORING PET FOR IN VIVO MONITORING AND - - PowerPoint PPT Presentation

WP19 PET FOR IN VIVO MONITORING WP19 – PET FOR IN VIVO MONITORING AND THERAPY OPTIMIZATION

Karolinska Institutet Stockholm, Sweden

PARTNER Ki k Off M ti t CERN 16 17 O t b 2008 PARTNER Kick Off Meeting at CERN, 16-17 October 2008

Milestones and deliverables

• 19-M1

Design of PET camera with Excentric Gantry. Design of PET camera that is fully integrated with a light ion Excentric Gantry allowing its use in four different treatment rooms.

(m12) ( )

• 19-D1

Design of PET camera with Excentric Gantry. (m12, PP)

• 19-M2

Dose delivery imaging. Study of the different advantages of dose delivery imaging using 11C and 8B versus 6Li

10-11B 12C which are active PET emitters

imaging using C and B versus Li, B, C which are active PET emitters versus stable nuclei. (m24)

• 19-D2

Dose delivery imaging. Study of the different advantages of dose delivery imaging using 11C and 8B versus 6Li, 10-11B and 12C. (m24, PP)

• 19-M3

PET based light ion therapy. PET and PET-CT based light ion therapy planning and treatment optimisation. (m36)

• 19-D3

PET based light ion therapy planning and treatment optimisation. (m36, PP)

• 19-M4

Development of the full BIOART approach. Development of the full BIOART approach where biologically optimised 3D in vivo predictive assay is used together with ion beam IMRT. (m48)

• 19 D4

Development of the full BIOART approach (m48 PP)

2

• 19-D4

Development of the full BIOART approach. (m48, PP)

WP19 D1 - Design of PET camera with Excentric Gantry

Artist impression of the excentric gantry design allowing dose delivery in several treatment rooms placed around it. A PET camera could be incorporated into the gantry in one of the treatment rooms. (Brahme Int J Radiat Oncol Biol Phys. 2004 Feb 1;58(2):603-16)

WP19 D2 - Dose delivery imaging using 11C and 8B versus 6Li, 10-11B and 12C

PET image of the three-dimensional in vivo dose delivery distribution. Positron emitters 11C and 15O are produced through nuclear reactions from 12C and Comparison of the PET activity induced by 12C and 11C ion beams in water. A considerably higher sensitivity to detect the primary carbon ion Bragg peak with 11C beam is clearly seen through nuclear reactions from 12C and

16O (Brahme et al Med Phys. 2008

May;35(5):1670-81) ion Bragg peak with C beam is clearly seen. This is of considerable importance for accurate in vivo dose delivery imaging far beyond what can be done with 12C.

WP19 D3 - PET based light ion therapy planning and treatment optimisation

WP19 D4 - Development of the full BIOART approach

BIOART using PET-CT Imaging (Brahme Acta Oncol 42 (2003) 123.)