Using social networking and ar1ficial intelligence to collect FHx - - PowerPoint PPT Presentation

▶
using social networking and ar1ficial intelligence to
SMART_READER_LITE
LIVE PREVIEW

Using social networking and ar1ficial intelligence to collect FHx - - PowerPoint PPT Presentation

Jul 09, 2023 229 likes •715 views

Using social networking and ar1ficial intelligence to collect FHx Brandon M Welch, MS, PhD Assistant Professor Medical University of South Carolina Family history is important Cancer runs in families Life6me risk for breast cancer 70% 60%

slide-1
SLIDE 1

Using social networking and ar1ficial intelligence to collect FHx

Brandon M Welch, MS, PhD Assistant Professor Medical University of South Carolina
slide-2
SLIDE 2

Family history is important

slide-3
SLIDE 3

Cancer runs in families

slide-4
SLIDE 4

Life6me risk for breast cancer

0% 10% 20% 30% 40% 50% 60% 70% Average risk Smoker Drinker 1 FDR 2 FDR BRCA2 3 FDR BRCA1 Average risk Smoker Drinker 1 FDR 2 FDR BRCA2 3 FDR BRCA1
slide-5
SLIDE 5

Most people have cancer in the family

0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100% Smokes Close family (parent, sibling) Extended family (+ grandparents, aunts/uncles)

% of US populaPon

Smokes Breast cancer Colon cancer Prostate cancer Lung cancer
slide-6
SLIDE 6

It’s in the family, but where’s the gene?

slide-7
SLIDE 7

VUS = fly in gene6c tes6ng ointment

slide-8
SLIDE 8

VUSs are growing

slide-9
SLIDE 9

Use family history to make sense of VUSs

slide-10
SLIDE 10

Collec6on of FHx

slide-11
SLIDE 11

<4%

slide-12
SLIDE 12

Time needed 20-30 minutes Time spent 2.5 minutes

slide-13
SLIDE 13

30-90%

accurate

100% 0% Breast cancer Mental health
slide-14
SLIDE 14

Clinicians don’t have 1me to collect a bad FHx

slide-15
SLIDE 15 PMID: 15538320
slide-16
SLIDE 16
slide-17
SLIDE 17
slide-18
SLIDE 18
slide-19
SLIDE 19

“painful to use”

  • Poor user interface design
  • Complicated and illogical quesPons
  • System crashes
  • High user workload

1 in 10

complete FHx

3 of 4

never finished

slide-20
SLIDE 20
slide-21
SLIDE 21
slide-22
SLIDE 22

Reimagine FHx collec6on

slide-23
SLIDE 23 PMID: 25868012

Leverage the family social network Interoperable with EHRs Provide care recommendations Support clinical research

slide-24
SLIDE 24
slide-25
SLIDE 25
slide-26
SLIDE 26

Chatbots

slide-27
SLIDE 27
slide-28
SLIDE 28
slide-29
SLIDE 29
slide-30
SLIDE 30
slide-31
SLIDE 31
slide-32
SLIDE 32

How lik likely ely would you use ItRuns?

PMID: 26958272
slide-33
SLIDE 33
  • MVP complete
  • Open beta
  • Pilot studies
  • HL7 interoperability
Under development

Phase 1 Phase 2

slide-34
SLIDE 34
slide-35
SLIDE 35

FHx risk assessment

slide-36
SLIDE 36

Family cancer risk assessment is a me mess

Risk for breast cancer Risk for colon cancer Risk for Lynch syndrome Risk for BRCA gene Risk for
  • varian cancer
Risk for Li Fraumeni syndrome Risk PancreaPc cancer Risk for FAP Risk for RAD51 gene

Couch Gail Claus Penn II Myriad Tyrer-Cuzick BRCAPRO BOADICEA BRST Wijnen MMRpro MMRPredict PREMM1,2,6

Risk for skin cancer

MELApro Pancpro

Risk for prostate cancer Cancer Guidelines 531 statements 55 guidelines published 11 different organizaPons
slide-37
SLIDE 37
slide-38
SLIDE 38
slide-39
SLIDE 39 Risk for breast cancer Risk for colon cancer Risk for Lynch syndrome Risk for BRCA gene Risk for
  • varian cancer
Risk for Li Fraumeni syndrome Risk PancreaPc cancer Risk for FAP Risk for RAD51 gene Risk for skin cancer Risk for prostate cancer

Unified Hereditary Cancer Assessment Tool (U-CHAT)

Unify the risk tools

slide-40
SLIDE 40

Unified Hereditary Cancer Assessment Tool (U-CHAT)

Under development
slide-41
SLIDE 41

Opportuni6es

slide-42
SLIDE 42

Cancer risk

slide-43
SLIDE 43

Personalize care

slide-44
SLIDE 44

Genome discovery

slide-45
SLIDE 45

Research recruitment

slide-46
SLIDE 46

Data collecPon and storage

as a pladorm

ApplicaPon & funcPonality

Open collabora6on plaTorm

slide-47
SLIDE 47