Topical workshop on Radiation biology Topical workshop on Radiation - PowerPoint PPT Presentation

Topical workshop on Radiation biology Topical workshop on Radiation biology September 2010 (B.2.3. Training) Medical Radiation Physics Department of Oncology-Pathology f O Karolinska Institutet Stockholm, Sweden ,

Visiting scientists Visiting scientists � Prof. Adrian Begg from Division of Experimental Therapy, Netherlands Cancer Institute, The Netherlands . Adrian Begg (SVS) carried out his PhD research at the University of London, firstly within Hammersmith Hospital and subsequently at the Cancer Research Campaign Gray Laboratory. He studied the cell kinetics of murine tumors in relation to their radiation response under the supervision of Jack Fowler. He then held a 3-year di ti d th i i f J k F l H th h ld 3 post-doctoral position at the University of California Medical Center, San Francisco, studying the interaction of cytotoxic drugs and radiation. He became head of the Experimental Therapy division in 1990, and Professor of Molecular Radiobiology attached to Nijmegen University in 2002. attached to Nijmegen University in 2002. � Prof. Karin Haustermans from Universitair Ziekenhuis Leuven, Belgium. Karin Haustermans (SVS) obtained an M.D. degree at the Catholic University of Karin Haustermans (SVS) obtained an M D degree at the Catholic University of Leuven (KUL) (1987) and specialised in Radiation Oncology (1993). She obtained a Ph.D. in biomedical sciences with a thesis on cell kinetics in human oesophageal cancer (1995). Nowadays she is clinical head in digestive and urological oncology. She has obtained several research grants from the Fund for Scientific Research g (Belgium), the Dutch Cancer Society (the Netherlands) and an R21 from NCI (U.S.A). 2

Introduction Physics of radiation interaction Physics of radiation interaction A Brahme A. Brahme Microdosimetrical aspects L. Lindborg Molecular radiobiology Molecular basis of radiation response: f - Genetic pathways - DNA response - Apoptosis and checkpoints Apoptosis and checkpoints A Begg A. Begg Molecular approaches to radiation therapy A. Begg 3

Basic radiobiology Clonogenic cells cell death and survival Clonogenic cells, cell death and survival M Edgren M. Edgren Repair of radiation damage and dose-rate effect B. Stenerlöw LET and RBE A. Brahme Biological dosimetry M. Harms-Ringdahl Models of radiation cell killing: - LQ - RCR RCR - Models of cell killing for light and heavy ions irradiation - Binomial and Poisson models B. Lind 4

Clinical radiobiology Clinical response of normal tissue I. Turesson Time, dose and fractionation in radiation therapy I. Dasu Oxygen effect and tumour hypoxi I. Dasu Treatment strategies to overcome tumour radiorestance - Ion therapy A. Brahme Treatment strategies to overcome tumour radioresistance - Radiosensitizers and bioreductive drugs M. Edgren Dose-response realtionships from clinical data D lti hi f li i l d t P M P. Mavroidis idi Radiation induced damage in long term survivors A. Dasu A clinicians view of radiobiology A clinicians view of radiobiology K Haustermans K. Haustermans 5

Biologically based treatment optimisation Subcelluar radiation biology Subcelluar radiation biology B Lind B. Lind Systems biology of radiation therapy optimisation A.Brahme BIOART (Predictive assay based radiation therapy) A. Brahme Application of BIOART concept I. Dasu, J. Uhrdin 6