Topical workshop on Radiation biology Topical workshop on Radiation - - PowerPoint PPT Presentation

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Topical workshop on Radiation biology Topical workshop on Radiation - - PowerPoint PPT Presentation

Topical workshop on Radiation biology Topical workshop on Radiation biology September 2010 (B.2.3. Training) Medical Radiation Physics Department of Oncology-Pathology f O Karolinska Institutet Stockholm, Sweden , Visiting scientists


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Topical workshop on Radiation biology Topical workshop on Radiation biology September 2010 (B.2.3. Training)

Medical Radiation Physics f O Department of Oncology-Pathology Karolinska Institutet Stockholm, Sweden ,

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Visiting scientists Visiting scientists

  • Prof. Adrian Begg from Division of Experimental Therapy, Netherlands

Cancer Institute, The Netherlands.

Adrian Begg (SVS) carried out his PhD research at the University of London, firstly within Hammersmith Hospital and subsequently at the Cancer Research Campaign Gray Laboratory. He studied the cell kinetics of murine tumors in relation to their di ti d th i i f J k F l H th h ld 3 radiation response under the supervision of Jack Fowler. He then held a 3-year post-doctoral position at the University of California Medical Center, San Francisco, studying the interaction of cytotoxic drugs and radiation. He became head of the Experimental Therapy division in 1990, and Professor of Molecular Radiobiology attached to Nijmegen University in 2002. attached to Nijmegen University in 2002.

  • Prof. Karin Haustermans from Universitair Ziekenhuis Leuven, Belgium.

Karin Haustermans (SVS) obtained an M D degree at the Catholic University of Karin Haustermans (SVS) obtained an M.D. degree at the Catholic University of Leuven (KUL) (1987) and specialised in Radiation Oncology (1993). She obtained a Ph.D. in biomedical sciences with a thesis on cell kinetics in human oesophageal cancer (1995). Nowadays she is clinical head in digestive and urological oncology. She has obtained several research grants from the Fund for Scientific Research

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g (Belgium), the Dutch Cancer Society (the Netherlands) and an R21 from NCI (U.S.A).

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Introduction

Physics of radiation interaction A Brahme Physics of radiation interaction

  • A. Brahme

Microdosimetrical aspects

  • L. Lindborg

Molecular radiobiology

f Molecular basis of radiation response:

  • Genetic pathways
  • DNA response

Apoptosis and checkpoints A Begg

  • Apoptosis and checkpoints
  • A. Begg

Molecular approaches to radiation therapy

  • A. Begg

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Basic radiobiology

Clonogenic cells cell death and survival M Edgren Clonogenic cells, cell death and survival

  • M. Edgren

Repair of radiation damage and dose-rate effect

  • B. Stenerlöw

LET and RBE

  • A. Brahme

Biological dosimetry

  • M. Harms-Ringdahl

Models of radiation cell killing:

  • LQ

RCR

  • RCR
  • Models of cell killing for light and heavy ions irradiation
  • Binomial and Poisson models
  • B. Lind

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Clinical radiobiology

Clinical response of normal tissue

  • I. Turesson

Time, dose and fractionation in radiation therapy

  • I. Dasu

Oxygen effect and tumour hypoxi

  • I. Dasu

Treatment strategies to overcome tumour radiorestance

  • Ion therapy
  • A. Brahme

Treatment strategies to overcome tumour radioresistance

  • Radiosensitizers and bioreductive drugs
  • M. Edgren

D lti hi f li i l d t P M idi Dose-response realtionships from clinical data

  • P. Mavroidis

Radiation induced damage in long term survivors

  • A. Dasu

A clinicians view of radiobiology K Haustermans

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A clinicians view of radiobiology

  • K. Haustermans
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Biologically based treatment optimisation

Subcelluar radiation biology B Lind Subcelluar radiation biology

  • B. Lind

Systems biology of radiation therapy optimisation A.Brahme BIOART (Predictive assay based radiation therapy)

  • A. Brahme

Application of BIOART concept

  • I. Dasu, J. Uhrdin

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