The Skin Clinic Marlborough The Skin Clinic Marlborough The Skin - - PowerPoint PPT Presentation

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The Skin Clinic Marlborough The Skin Clinic Marlborough The Skin - - PowerPoint PPT Presentation

Feb 23, 2023 462 likes •922 views

The Skin Clinic Marlborough The Skin Clinic Marlborough The Skin Clinic Marlborough The Skin Clinic Marlborough Melanoma The Skin Clinic Marlborough Common Skin Cancers Melanoma - Insitu - Invasive - Metastatic The Skin Clinic

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The Skin Clinic Marlborough

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The Skin Clinic Marlborough

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The Skin Clinic Marlborough

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The Skin Clinic Marlborough

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Melanoma

The Skin Clinic Marlborough

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Common Skin Cancers

The Skin Clinic Marlborough

Melanoma

  • Insitu
  • Invasive
  • Metastatic
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Epidermal – insitu Dermis - invasive

The Skin Clinic Marlborough

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MIS

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The Skin Clinic Marlborough

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Melanoma Insitu

The Skin Clinic Marlborough

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Melanoma can be BCC like

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MIS

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The Skin Clinic Marlborough

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Breslow 0.55mm

The Skin Clinic Marlborough

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The Skin Clinic Marlborough

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Melanoma Breslow 2.5 mm

The Skin Clinic Marlborough

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Nodular Melanoma 3.5 mm

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The Skin Clinic Marlborough

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THANK YOU

November 2013 – Dr Mark Foley

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The Skin Clinic Marlborough

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 Why the delay in UV exposure and

development of skin cancer

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 UV light causes DNA damage  Initial understanding

  • DNA repair or
  • If not able to be repaired -> apoptosis (programmed cell

death).

  • If both fail DNA damage should be reproduced in the next cell

cycle – but if this was true skin cancers would start in early childhood…..

  • In reality DNA damage can take decades to be expressed.

The Skin Clinic Marlborough

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Response to damaged DNA

 DNA repair  Apoptosis  Senescence

  • Replicative
  • Premature

The Skin Clinic Marlborough

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The Skin Clinic Marlborough

Replicative senescence - result of the countdown of an intrinsic mitotic counter. The only known mitotic counter mechanism is telomere shortening. This mechanism seems to be responsible for the induction of replicative senescence in human diploid fibroblasts. Premature senescence - induced by extrinsic factors that can act at any point in a cell's replicative history

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The Skin Clinic Marlborough

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Dermoscopy / Dermatoscopy

The Skin Clinic Marlborough

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The Skin Clinic Marlborough

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Dermoscopy

Allows visualisation of skin architecture not able to be seen with the naked eye. Dramatically improves ability to diagnose early skin cancer and benign lesions Contact vs Polarising Dermoscopy vs TBP

The Skin Clinic Marlborough

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The Skin Clinic Marlborough

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The Skin Clinic Marlborough

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The Skin Clinic Marlborough

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The Skin Clinic Marlborough

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T wo important dermoscopic signs for red scaly lesions

 These will improve your pick up rate

dramatically

The Skin Clinic Marlborough

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Arborising vessels

The Skin Clinic Marlborough

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Coiled vessels

The Skin Clinic Marlborough

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BCC SCC insitu

The Skin Clinic Marlborough

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SCC background

The Skin Clinic Marlborough

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The Skin Clinic Marlborough

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The Skin Clinic Marlborough

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The Skin Clinic Marlborough