The CompNet resistance module: Current status Klaus Jansen Cohort - PowerPoint PPT Presentation

The CompNet resistance module: Current status Klaus Jansen Cohort Manager Competence Network for HIV/AIDS

Aims of CompNet resistance database � Completing nationwide CompNet cohort with retrospective and prospective resistance data of patients � Providing a sufficient basis for epidemiological and virological research on the CompNet-cohort � Providing data to supplement national and international collaborations

Topics of scientific interest � Prevalence of resistant HIV in population of CompNet-cohort � Differences in therapy outcomes in patients having resistant HIV or in patients having not � Differences in therapy outcomes in patients having a previuos resistance testing and harmonised therapy and in patients having no testing � Analyses of impact of resistances on TCE � Identification of new resistance patterns of new therapeutic regimens � Impact of differing variants of HIV on clinical outcome of treated patients .....

CompNet-cohort Composition Basis-Module: 25 HIV-centres � 10 clinics � 15 special. private practitioners Resistence-Module: 9 Labs Children-Cohort: 8 centres Pregnancy-Cohort: 10 centres Neurology-Module: 1 centre Central Office CompNet CCT Cologne

CompNet-cohort � Prospective und retrospective documentation of 283 soziodemographic and clinical items as well as collection of biological samples (using SOPs) Central characteristics of the cohort: � Number of patients: ~ 8,200 � Person years: ~ 43.500 in treated patients � Proportion of women: 14.9% � Risk of infection: 62.4% MSM, 18.3% Hetero, 7.5% IVDU, 4.8% HPL � Therapy status: 8.9% ART-naive, 7.9% initially treated � Mean duration since positive HIV-diagnosis: 10.3 years

Current status � IT-tool for entry, storage and analyses: SmartGene-software � Implemented targets: PR, RT, IN, gp41 � Implementation of pilot centre Erlangen in 10/08 � Implementation and software-trainings in 6 labs by now � Completion envisaged within next weeks � First step: compiling of retrospective data set manually till complete implementation of software � Partly, greater efforts while identifying retrospective sequences due to changes in lab-documentation systems etc.

Current status � Only inclusion of data of patients having international IC � Only existing sequences are recorded, no new testing � Current coverage of CompNet-patients by 9 labs: ~ 76% � Current N of eligible patients: 1,406 � Current N of documented sequences: 814 � Expected N of eligible patients: ~ 5,500

Data and Networking � Sharing of data set with researchers from inside and outside of CompNet appreciated � Requests possible for virologic data as well as in combination with clinical and sociodemographic data � Short proposal needed for conducting scientific projects � Proposal evaluated by scientific boards and SC of CompNet � After evaluation of proposal, data could be provided in different formats

Data and Networking � Sharing of data with scientific networks highly appreciated: - national level: AREVIR, RESINA, Seroconverter-study - international level: CHAIN, EHR, EuResist… � Important: analysing and avoiding overlaps with other German patient populations � only slight overlaps expected � CompNet population can supplement collaborations substiantially

Next steps � Implementation of all labs � Completion of international IC � Completion of retrospective resistance data � Ongoing documentation of prospective resistance data � Compiling complete dataset after completion of retrospective resistance data � Clarifying overlaps with other existing German populations � Distributing data to researchers and research collaborations

Thanks � To all collaborating laboratories and their staff � To Virco for good collaboration � To Hauke Walter And you for your attention!