Jinsang Kim Molecular Design for Optical Chemical & Biosensors - - PowerPoint PPT Presentation

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Jinsang Kim Molecular Design for Optical Chemical & Biosensors - - PowerPoint PPT Presentation

Mar 29, 2023 25 likes •127 views

Jinsang Kim Molecular Design for Optical Chemical & Biosensors Plastic Electronics Circulating Tumor Cell Detection Chemical Sci 2016 Liquid Crystalline CPs Platelet Activation Monitoring Adv. Mater. 2016 Field Effect Transistor miRNA

slide-1
SLIDE 1

Optical Chemical & Biosensors

Organic Light Emitters Designer Functional Organic and Polymer

Rationally designed strong intermolecular hydrogen and halogen bonds between a novel phosphor and a poly(vinyl alcohol) (PVA) matrix led to bright room- temperature phosphorescence with a quantum yield of 24%. J. Kim and co-workers show in their Communication (10.1002/anie.201404490) that modulation of the strength of halogen and hydrogen bonding in the purely organic phosphor–PVA system by water enabled reversible switching between phosphorescence (green) and fluorescence (blue). G1 in PVA (100%) Φph~ up to 24 %

b

O H H O O O O Br O O O H H O Ar O H H O O O O Br O O O H H O Ar O H O H O H O H H O H O H O Hydrogen bonding Halogen bonding O H O H H O O H H O O O O Br O O O H H O Ar S T

X

Phos. Vibrational Dissipation G1-G1Halogen Bond
  • 1. Heavy atom effect
  • 2. Restrict vibration motion
  • f phosphors
PVA-PVA Hydrogen Bond Suppress the diffusional motion of matrix G1-PVA Hydrogen Bond Reinforce the restriction
  • f vibration of phosphors
H2O writing Drying

c

Water Induced Phosphorescence to Fluorescence Switching for Water Sensing Applications

a

O O Br H O OH HO O O

G1 PVA OH n

O O Br H O

Br6A

Circulating Tumor Cell Detection Platelet Activation Monitoring miRNA Detection Chemical Sci 2016

  • Adv. Mater. 2016

Organic Phosphors LED, Sensors, Solid-state Lighting,

  • Nat. Chem. 2011
  • J. Am. Chem. Soc. 2013
  • Angew. Chem. 2014
  • Chem. Mater. 2014
  • Nat. Commun. 2015
  • Angew. Chem. 2017

Chem Mater 2019

Heat Management in Polymers Biomimetic Adhesives and Surface Functionalization

Nature Materials 2015 ACS Central Sci. 2015 Science Advances 2017

editorials NATURE MATERIALS

S S O O F F S

1" 2" 3"

PBTCT PBTCTO PBTFDO PBTPDO

Molecular Design for Plastic Electronics

  • Nat. Mater. 2013

Chemical Sci. 2015

  • Adv. Mater. 2016

Macromolecules 2019

Liquid Crystalline CPs Field Effect Transistor Thermoelectric Polymers

Jinsang Kim

slide-2
SLIDE 2

conjugated p-orbital twisted p-orbital target

color change

(Increased response) Glucose sensor (boronic acid) DNA sensor Reversible sensor Antibody-antigen sensor Virus sensor Peptide sensor Temperature sensor (polyNIPAM) Virus Antigen Peptide receptor

Blue Color Red Color + Target Non-fluorescent Fluorescent

Application of Polydiacetylene Sensors

Developed Sensors

  • Nerve Agents
  • Antibiotics
  • Melamine
  • Proteins
  • Hg2+
  • Influenza Virus
  • Prostate Specific Antigen
  • K+
  • DNA
  • Immunofluorescence labeling
slide-3
SLIDE 3

conjugated p-orbitals

partially twisted p-orbitals

Repulsion Fluorometric & Colorimetric Dual Signal

Disrupting pi-conjugation of PDA triggers optical signals

slide-4
SLIDE 4

+ Na+ + K+

0.01 0.05 0.1 0.25 0.5 1.0 ×10-3 mol

K+ Sensor JACS 2008, 130, 5010. Nerve gas sensor Adv. Func. Mater. 2010 and 2012.

Mercury Sensor Adv. Mater. 2009, 21, 3674. Melamine sensor Chem Comm 2010, 47, 358.

Antidote

(2-PAM)

HCl HF H3PO4 DCP DFP Control

Polychromatic optical waveguiding is achieved for organic nanowires (NWs) hybridized with light-emitting quantum dots (QDs). Remote biosensing using dye-attached biomaterials is presented by J. Kim,
  • J. Kim, J. Joo, and co-workers by adapting the transportation of QD-
emitted light through the organic NWs. The cover image shows white- color waveguiding and remote biosensing using blue light-emitting
  • rganic NWs hybridized with QDs.
OPTICAL WAVEGUIDING

Developed Sensors

Nerve Agents Bacteria & Influenza Virus A Antibiotics Melamine Prostate Specific Antigen DNA Mercury Potassium Water

Self-signaling and Signal-amplifying Optical Sensors

slide-5
SLIDE 5

Color Tuning & Conducting Property

  • Electron Density of the Core Unit
  • Extended Conjugation in the Core Unit
  • Conducting Property

Understanding the Intermolecular Phenomena

  • Halogen Bonding
  • Crystallography and Photophysics
  • Emission Intensity vs. Crystal

Fundamentals:

  • Materials Chemistry
  • Molecular Photophysics
  • Device Physics

Applications:

  • Solid-state Lighting
  • Light Emitting Diodes
  • Photovoltaics
  • Polarized Emission Devices

Novel Emissive Materials by Design

Rationally designed strong intermolecular hydrogen and halogen bonds between a novel phosphor and a poly(vinyl alcohol) (PVA) matrix led to bright room- temperature phosphorescence with a quantum yield of 24%. J. Kim and co-workers show in their Communication (10.1002/anie.201404490) that modulation of the strength of halogen and hydrogen bonding in the purely organic phosphor–PVA system by water enabled reversible switching between phosphorescence (green) and fluorescence (blue).

Nature Chemistry 2011, 3, 205.

  • J. of Am. Chem. Soc. 2013, 135, 6325.
  • Angew. Chem. Inter. Ed. 2014, 53, 11177.
  • Chem. Mater. 2014, 26, 6644.

Nature Communications 2015, 6, 8947.

  • Angew. Chem. Inter. Ed. 2017, 56, 16207.

Hot water Cold water

Phosphorescence*Intensity*

Argon Air

Nanoparticles

“On”

slide-6
SLIDE 6

S S O O F F S

1" 2" 3"

CP1

  • 1. Concentra,on-induced Chain Planariza,on
  • 2. Non-interdigita,ng Large Side Chain
  • 3. Out-of-plane Tetrahedral Carbon Linker

Lyotropic Liquid Crystalline CP Design for Directed Conjugated Polymer Alignment

Bong-Gi Kim, Eun Jeong Jeong, Jong Won Chung, Sungbaek Seo, Bonwon Koo, Jinsang Kim Nature Materials 2013, 12, 659.

1 Concentration induced chain planarization 2 Bulky side chain attached on 3 a Tetrahedral carbon

  • Strong π−π aggregation
  • Side chain interdigitation

Suppressed Enabled

LC-like mobility & directed alignment

Shear field

Solvent evaporation causes chain planarization and CP assembly

Shear field aligns CP

substrate

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SLIDE 7

600 650 700 750 800

PL intensity (a. u.)

  • to polarizer

45

  • 90
  • 135
  • Wavelength (nm)

0o 45o 90o spin casting

10

  • 5

10

  • 4

10

  • 3

10

  • 2

10

  • 1

10

mobility (cm

2/Vs)

Aligned direction to S-D electrode

90o$

45o$

0o#

Hole mobility by TFT

S S O O F F S

1" 2" 3"

250 mg/ml

125 mg/ml

slide-8
SLIDE 8

OH O m O- O m Na+ High pH Low pH

PAA

n O

PVP

High Thermal Conductivity in Amorphous Polymers

Gun-Ho Kim+, Dongwook Lee+, Apoorv Shanker+ et al Nature Materials 2015, 14, 295.

Polymer Blend System Polyelectrolyte System

Coiled and entangled polyelectrolyte chains Low k Extended or swollen polyelectrolyte chains High k

  • Apoorv Shanker+, Chen Li+ et al

Science Advances 2017, 3, 1700342.

slide-9
SLIDE 9

Gun-Ho Kim+, Dongwook Lee+, Apoorv Shanker+, Lei Shao, Min Sang Kwon, David Gidley, Jinsang Kim* and Kevin Pipe* “High thermal conductivity in amorphous polymer blends by engineered interchain interactions” Nature Materials 2015, 14, 295.

  • 1. Through Interpolymer Bonding
slide-10
SLIDE 10
  • 2. Electrostatically Induced Random Chain Extension

Apporv Shanker+, Chen Li+, Gun-Ho Kim, David Gidley, Kevin Pipe*, Jinsang Kim* “Electrostatically induced random chain extension for high thermal conductivity in amorphous polymers” Science Advances 2017, 3, 1700342.