Fault Sim ulation of Heterogeneous I ntegrated Biological System s - - PowerPoint PPT Presentation

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Fault Sim ulation of Heterogeneous I ntegrated Biological System s - - PowerPoint PPT Presentation

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Fault Sim ulation of Heterogeneous I ntegrated Biological System s H.G. Kerkhoff & X. Zhang Jun-06 Design for Micro & Nano Manufacture (NoE PATENT-DfMM) Network of Excellence funded by the European Commission (EC FP6: IST, Unit

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SLIDE 1

Jun-06

«Design for Micro & Nano Manufacture (NoE PATENT-DfMM)»

Network of Excellence funded by the European Commission (EC FP6: IST, Unit C2, Contract 507255)

Fault Sim ulation of Heterogeneous I ntegrated Biological System s

H.G. Kerkhoff &

  • X. Zhang
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SLIDE 2

Jun-06

«Design for Micro & Nano Manufacture (NoE PATENT-DfMM)»

Network of Excellence funded by the European Commission (EC FP6: IST, Unit C2, Contract 507255)

Contents

  • Introduction
  • Analog & digital microfluidics
  • Integrated homogeneous systems
  • Example: Peptide synthesis platform
  • Test issues:

fluidics, interface MEF & microelectronics

  • Possible test solutions
  • Joint VHDL-AMS fault-simulations for DfT
  • Conclusions
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SLIDE 3

Jun-06

«Design for Micro & Nano Manufacture (NoE PATENT-DfMM)»

Network of Excellence funded by the European Commission (EC FP6: IST, Unit C2, Contract 507255)

Analog Microfluidics: EOF Flow FETs

Gate electrodes Gate electrodes Gate electrodes S ilica isolation S ilica isolation S ilica isolation P yrex wafer P yrex wafer P yrex wafer Gate electrode Gate electrode Gate electrode

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SLIDE 4

Jun-06

«Design for Micro & Nano Manufacture (NoE PATENT-DfMM)»

Network of Excellence funded by the European Commission (EC FP6: IST, Unit C2, Contract 507255)

Digital Microfluidics: EW OD Droplets

2

2 1 cos )) ( cos( U d U

lv Y

σ ε ε θ θ + = electrowetting equation: η

U

droplet

electrode

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SLIDE 5

Jun-06

«Design for Micro & Nano Manufacture (NoE PATENT-DfMM)»

Network of Excellence funded by the European Commission (EC FP6: IST, Unit C2, Contract 507255)

Previous „I ntegrated“ MEF System s

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SLIDE 6

Jun-06

«Design for Micro & Nano Manufacture (NoE PATENT-DfMM)»

Network of Excellence funded by the European Commission (EC FP6: IST, Unit C2, Contract 507255)

I ntegrated Hom ogenous MEF Construction

capacitive

  • bservation
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SLIDE 7

Jun-06

«Design for Micro & Nano Manufacture (NoE PATENT-DfMM)»

Network of Excellence funded by the European Commission (EC FP6: IST, Unit C2, Contract 507255)

Features Heterogenous I ntegrated System

  • Based on mainstream industrial (automotive)

process of Philips Semiconductors (A-BCD3)+ BEP

  • Uses 90nm CMOS processing capabilities
  • Integrates 40V - 120V DMOS transistors for control
  • Uses pizza-topping techniques for merging with fluidic

parts; electrodes can be contacted with CMOS parts

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SLIDE 8

Jun-06

«Design for Micro & Nano Manufacture (NoE PATENT-DfMM)»

Network of Excellence funded by the European Commission (EC FP6: IST, Unit C2, Contract 507255)

Peptide Synthesis Fluidic Transport

  • Use microfluidic structures for fluidic transport
  • More flexibility & less parasitic effects
  • Application to peptide synthesis > diseases
  • Currently done at macro scale & very expensive
  • Enables massive parallel synthesis
  • Enables multiple different peptides
  • Using e.g. SPOT & Fomoc techniques
  • Nice self-testing & repair features
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SLIDE 9

Jun-06

«Design for Micro & Nano Manufacture (NoE PATENT-DfMM)»

Network of Excellence funded by the European Commission (EC FP6: IST, Unit C2, Contract 507255)

Peptide Synthesis Principle

Formation of the peptide bond

2

2 2 1 1 H O 2 2

R R R R O O || | || | | | H N C OH + H N C COOH H N C N C COOH C C | | | | | | H H H H H H

−

− − − − − − ⎯⎯⎯ → − − − − −

Amino acid R1 Amino acid R2 Mono Peptide by-product Now: 7-stage peptides for EB & Pfeifer virus detection

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SLIDE 10

Jun-06

«Design for Micro & Nano Manufacture (NoE PATENT-DfMM)»

Network of Excellence funded by the European Commission (EC FP6: IST, Unit C2, Contract 507255)

Sym bolic Schem e Peptide Synthesizer

Amino acids 1 DMF Reagent Reaction spot Waste tank Peptide collector 2 4 3

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SLIDE 11

Jun-06

«Design for Micro & Nano Manufacture (NoE PATENT-DfMM)»

Network of Excellence funded by the European Commission (EC FP6: IST, Unit C2, Contract 507255)

Heterogeneous I ntegrated Fluidic Chip

CMOS-DMOS System on Chip interconnections fluidic topping Production Platform removable peptide substrate

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SLIDE 12

Jun-06

«Design for Micro & Nano Manufacture (NoE PATENT-DfMM)»

Network of Excellence funded by the European Commission (EC FP6: IST, Unit C2, Contract 507255)

Altera Cyclon Memory 512 kB DMOSTs Fluidic Chip fluidic SoC

Electrodes

control sensing rerouting vast DSP fluid flow PDA Com.

library (e.g. peptide)

fluid flow

sensing

VHDL available

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SLIDE 13

Jun-06

«Design for Micro & Nano Manufacture (NoE PATENT-DfMM)»

Network of Excellence funded by the European Commission (EC FP6: IST, Unit C2, Contract 507255)

Layout/ I m plem entation of Fluidic A-BCD3 Chip

electrode G sensing

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SLIDE 14

Jun-06

«Design for Micro & Nano Manufacture (NoE PATENT-DfMM)»

Network of Excellence funded by the European Commission (EC FP6: IST, Unit C2, Contract 507255)

Different Sizes in Bio System s

c Contamination in biomaterial -> clog

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SLIDE 15

Jun-06

«Design for Micro & Nano Manufacture (NoE PATENT-DfMM)»

Network of Excellence funded by the European Commission (EC FP6: IST, Unit C2, Contract 507255)

Tim e-Dependent Faults in Bio System s

c Contamination in biomaterial -> clog 200 um

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SLIDE 16

Jun-06

«Design for Micro & Nano Manufacture (NoE PATENT-DfMM)»

Network of Excellence funded by the European Commission (EC FP6: IST, Unit C2, Contract 507255)

Testing Schem e Cycle of MEF System

Electrode layout

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SLIDE 17

Jun-06

«Design for Micro & Nano Manufacture (NoE PATENT-DfMM)»

Network of Excellence funded by the European Commission (EC FP6: IST, Unit C2, Contract 507255)

The Used DMOS A-BCD3 Transistors

Courtesy of Philips Sem iconductors

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SLIDE 18

Jun-06

«Design for Micro & Nano Manufacture (NoE PATENT-DfMM)»

Network of Excellence funded by the European Commission (EC FP6: IST, Unit C2, Contract 507255)

DMOS Tristate Fluidic Control Schem e

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SLIDE 19

Jun-06

«Design for Micro & Nano Manufacture (NoE PATENT-DfMM)»

Network of Excellence funded by the European Commission (EC FP6: IST, Unit C2, Contract 507255)

DMOS Control Behaviour

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SLIDE 20

Jun-06

«Design for Micro & Nano Manufacture (NoE PATENT-DfMM)»

Network of Excellence funded by the European Commission (EC FP6: IST, Unit C2, Contract 507255)

Direct connections via/or bump technology bondpad viak metalk electrode electrode

Critical: SoC to Fluidic Connections

viak-1 fluidic channel BEP

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SLIDE 21

Jun-06

«Design for Micro & Nano Manufacture (NoE PATENT-DfMM)»

Network of Excellence funded by the European Commission (EC FP6: IST, Unit C2, Contract 507255)

Connectivity & C Test W ithout Fluidics

P-DMOS

control Vhigh logic test enable

f

Rpar (0-100MΩ) Celec (30 - 60 pF) Rpar (0-100MΩ) Celec (30 - 60 pF)

Impedance measurement N-DMOS Ce1 Ce2 Z

test enable

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SLIDE 22

Jun-06

«Design for Micro & Nano Manufacture (NoE PATENT-DfMM)»

Network of Excellence funded by the European Commission (EC FP6: IST, Unit C2, Contract 507255)

MEF Fault Sim ulation in VHDL-AMS

c

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SLIDE 23

Jun-06

«Design for Micro & Nano Manufacture (NoE PATENT-DfMM)»

Network of Excellence funded by the European Commission (EC FP6: IST, Unit C2, Contract 507255)

Differences Due to Bio Clog in VHDL-AMS

c Fault-free Faulty

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SLIDE 24

Jun-06

«Design for Micro & Nano Manufacture (NoE PATENT-DfMM)»

Network of Excellence funded by the European Commission (EC FP6: IST, Unit C2, Contract 507255)

Conclusions

  • Used fluidic FEM & HDL modelling, simulation and

System-on-Chip tools for joint fault simulation

  • Helps to find the influence of defects in both domains
  • Promising, innovative industrial applications
  • New detection and control electronics are being

developed for testing and the system itself

  • Designed, implemented and tested a programmable

Micro-Electronic Fluidic array, proven for bio applications and ready for heterogeneous integration

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SLIDE 25

Jun-06

«Design for Micro & Nano Manufacture (NoE PATENT-DfMM)»

Network of Excellence funded by the European Commission (EC FP6: IST, Unit C2, Contract 507255)

Questions ?