Intra-operative nuclear imaging Using navigated gamma-probes for - - PowerPoint PPT Presentation

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Intra-operative nuclear imaging Using navigated gamma-probes for - - PowerPoint PPT Presentation

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chair for computer aided medical procedures (CAMP) | campar.in.tum.de department of nuclear medicine (MRI|NM) | www.nuk.med.tum.de Intra-operative nuclear imaging Using navigated gamma-probes for tumor localization Wendler, T.; Traub, J.;

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SLIDE 1 chair for computer aided medical procedures (CAMP) | campar.in.tum.de department of nuclear medicine (MRI|NM) | www.nuk.med.tum.de

03 July 2007

Chair for Computer Aided Medical Procedures Department of Computer Science | TU Munich Department of Nuclear Medicine Klinikum rechts der Isar | TU Munich

Wendler, T.; Traub, J.; Hartl, A.; Daghighian, F.*; Ziegler, S.I.; Navab, N. * IntraMedical Imaging LLC, Los Angeles

Intra-operative nuclear imaging

Using navigated gamma-probes for tumor localization

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SLIDE 2 chair for computer aided medical procedures (CAMP) | campar.in.tum.de department of nuclear medicine (MRI|NM) | www.nuk.med.tum.de

Background

  • For years Nuclear Medicine has been used for

surgical planning in cancer resection.

  • However, given the high-energy nature of most

cancer tracers, intra-operative assistance devices have been limited to high-energy γ- probes and β-probes1.

  • The combination of β-probes with navigation has

shown to offer novel intuitive approaches to radio-guided surgery2.

1 E.g. Essner et al. 2002, Meller et al. 2005, Piert et al. 2007… 2 Wendler et al. 2006, Kishenkov et al. 2007

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SLIDE 3 chair for computer aided medical procedures (CAMP) | campar.in.tum.de department of nuclear medicine (MRI|NM) | www.nuk.med.tum.de

Objectives

  • Evaluate the possibilities of using γ-probes

combined with navigation.

  • Development of a system capable of intra-
  • perative tomographic reconstruction.
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SLIDE 4 chair for computer aided medical procedures (CAMP) | campar.in.tum.de department of nuclear medicine (MRI|NM) | www.nuk.med.tum.de

Objectives

...

???

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SLIDE 5 chair for computer aided medical procedures (CAMP) | campar.in.tum.de department of nuclear medicine (MRI|NM) | www.nuk.med.tum.de

Materials

ART2 Cameras & DTrack, ART GmbH Biograph Sensation 16 PET/CT, Siemens γ-probe & NodeSeeker, IntraMedical Imaging LLC Multi-well phantom 0.1, 0.2 and 0.5 MBq F-18

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SLIDE 6 chair for computer aided medical procedures (CAMP) | campar.in.tum.de department of nuclear medicine (MRI|NM) | www.nuk.med.tum.de

Methods

Phantom preparation Navigated γ-probe scan PET/CT scan System matrix calculation Rigid registration Comparison Reconstruction

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SLIDE 7 chair for computer aided medical procedures (CAMP) | campar.in.tum.de department of nuclear medicine (MRI|NM) | www.nuk.med.tum.de

Methods

...

2-3 min

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SLIDE 8 chair for computer aided medical procedures (CAMP) | campar.in.tum.de department of nuclear medicine (MRI|NM) | www.nuk.med.tum.de

Results

Ground truth (real activity) Reconstructed image Corresponding PET slice

8 cm 12 cm

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SLIDE 9 chair for computer aided medical procedures (CAMP) | campar.in.tum.de department of nuclear medicine (MRI|NM) | www.nuk.med.tum.de

Conclusion

  • 2D reconstruction using γ-probes is possible.
  • These preliminary results introduce a promising

new alternative toward intra-operative 3D functional imaging.