Integrative human cardiovascular control Danish Cardiovascular - - PDF document

Integrative human cardiovascular control

Danish Cardiovascular Research Academy Ph.D. course The Panum Institute/Rigshospitalet, University of Copenhagen May 06 –10, 2019

Monday 6/5

Panum Institute Maersk Tower-top floor: 7.15.149

Topic and speaker Background literature - assignments

8:00 - 9.00 Welcome and introduction to the program - presentation of participants and speakers 9.00 - 10.30 Integrative human cardiovascular physiology: A primer to hypothesis-driven research

• 1. Developing the question; Mechanisms
• f exercise-induced Cardioprotection

Peter Raven, PhD, University of North Texas, Fort Worth, TX, USA

• 2. 20 years of skin graft research – How we

got to where we are. Craig G. Crandall PhD, University of Texas Southwestern Medical Center, Dallas, Texas, USA 10.30 - 11.00 Refreshments 11.00 - 11.30 Translational Research Primer: Understanding Hypertension through Animal and Human Investigation Scott Smith PhD, Dallas, Texas USA 11.30 - 12.00 Lunch 12.00 - 14.30 Presentation of Ph.D. projects 5 min each with expression of the hypothesis and the method(s) used. Paul Fadel, Johannes Van Lieshout, Peter Raven, Scott Smith 14.30 - 15.00 Refreshments 15.00 - 15.45 Heart function in animals Tobias Wang, Ph.D., Aarhus, Denmark Evening Social dinner at Bagsværd at 18.00 h., Adr: Skråvej 16, 2880 Bagsværd

Tuesday 7/5

Panum Institute Maersk Tower-top floor: 7.15.149

Central circulation Background literature - assignments

8.00- 9.30 Determination of cardiac output at rest and during exercise – Christoph Siebenmann PhD, Italy and Johannes Van Lieshout MD, DMSc , University of Amsterdam, Holland 9.30 – 10.00 MRI Evaluation of Cardiac function and myocardial perfusion – Per L Madsen, MD, DMSc, Herlev 10.00 -10.45 Arterial baroreflex control of heart rate and blood pressure. Peter B Raven 10.45-11.15 Refreshments 11.15 – 12.15 Workshop: Cardiac output and blood pressure regulation at rest and during exercise - baroreceptor reflex - Lars Nybo, Peter B Raven, James Fisher, Johannes Van Lieshout Demonstration 12.15-12.45 Lunch 12.45-14.45 Rigshospitalet 3111 , (entrance 3 , 11th floor, dept. 1) ECHO and Doppler evaluations of the heart and ultrasound assessment of peripheral circulation - Per L Madsen and Kim Bredahl, MD, PhD Demonstration 14.45-16.30 ECMO/Flow Per L Madsen and Kim Bredahl, MD, PhD Demonstration Evening Social networking time on your own

Wednesday 8/5

Panum Institute Maersk Tower-top floor: 7.15.149

Special circulations I - focus on cerebral blood flow and skin circulation Background literature - assignments

9.00 – 12.00 At the Panum Institute 16.3 Demonstration: Cardiovascular regulation in the pig. Rune Broni Strandby , Nicolaj Nerup, Lars Nybo Nielsen Demonstration 12.00–12.30 Lunch 12.30 – 13.00 Near infrared spectroscopy for evaluation of cerebral and muscle oxygenation, methodological considerations. Henrik Sørensen, MD, DMSc, Copenhagen 13.00 – 13.45 Cerebral blood flow: static and dynamic autoregulation, and relation to orthostatic stress - Johannes Van Lieshout

13.45 –14.15 Cardiovascular regulation during heat stress, changes in skin and cerebral perfusion,

• rthostatic tolerance and cardiac output.

Lars Nybo and Craig Crandall 14.15 – 14.45 Refreshments 14.45 – 15.30

Why the brain needs oxygen and gravity; a (free) radical perspective.

Damian Bailey PhD, University of South Wales, UK 15.30 – 16.15 Sympathetic activity and methods to assess sympathetic nerve activity. Paul Fadel PhD, Texas, USA Evening Social networking time on your own

Thursday 9/5

Panum Institute Maersk Tower-top floor: 7.15.149

Special circulations II - muscle perfusion, oxygenation and metabolism Background literature – assignments

8.00 – 9.00 Methods for determination of blood flow Stefan Mortensen, University of Southern Denmark 9.15 - 10.00

• 1. Regulation of skeletal muscle blood flow:

role of vasodilators - Ylva Hellsten PhD, Copenhagen

• 2. Skeletal muscle blood flow regulation:

sympatholysis - Stefan Mortensen, Odense 10.00 - 10.30 Refreshments 10.30 - 11.00 The exercise pressor reflex - interaction between cardiac output and muscle metabolism and blood flow. James Fisher, University of Birmingham, UK 11.00 – 11.30 Determination of blood volume Christoph Siebenmann, PhD, Italy 11.30 – 12.00 Cerebral and leg blood flow during exercise

• influence of dehydration and heat stress.

José González-Alonso PhD, Brunel University, UK 12.00-12:30 Lunch 12:30-13.00 Genetic influence on the circulation Niels V Olsen MD, DMSc, Copenhagen 13:00-13:30 Peripheral perfusion index in perioperative hemodynamic monitoring”? Marianne Agerskov, Copenhagen 13.00 -18.00 Social networking time on your own

18:00- Dinner at Strandberg & Co, Svanemøllen Strandvaenget 43 2100 Copenhagen Visit at DSR (The danish rowing club for students) between the buffet and dessert

Friday 10/5

Panum Institute Maersk Tower-top floor: 7.15.149

Special issues and summing up Background literature - assignments

8.00-9.30 Cerebral blood in liver failure Fin S Larsen, M.D., Ph.D., Copenhagen 9:30-10.15 Organ blood flow and metabolism Gerrit van Hall PhD, Copenhagen 10.15 – 11.00 Endothelia function in health and disease - Pär Johansson MD, PhD, Copenhagen 11.00 – 11.30 Coffee break 11.30 – 12.00 Central blood volume and maintenance of cardiac output, pressure and organ perfusion during surgery. Niels H. Secher, MD, DMSc 12.00 – 12.30 The orthostatic challenge as evaluated in the giraffe - Chr. Aalkjaer, MD, DMS, Aarhus. 12.30 – 13.30 Lunch and evaluation 13.30 – 16.00 Integrative cardiovascular aspects - Lars Nybo (questions. and discussion of topics from the week) Group examination - Lars Nybo

Course secretary: Jaime Latorre Finkelstein, Email: Jaime.finkelstein@regionh.dk, Telephone daytime: +45 3545 6120/private: +45 2735 1573