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AI in Integrative Health Shaista Malik, MD, PhD, MPH Professor, - PowerPoint PPT Presentation

AI in Integrative Health Shaista Malik, MD, PhD, MPH Professor, Department of Medicine Executive Director, Susan Samueli Integrative Health Institute Associate Vice Chancellor, Integrative Health Integrative Health Conventional Health Care


  1. AI in Integrative Health Shaista Malik, MD, PhD, MPH Professor, Department of Medicine Executive Director, Susan Samueli Integrative Health Institute Associate Vice Chancellor, Integrative Health

  2. Integrative Health Conventional Health Care Complementary Lifestyle & Alternative Medicine Medicine (Self Care)

  3. ORGAN SYSTEM DIAGNOSIS INTEGRATIVE PILLARS OF ANTECEDENTS, HEALTH AND TRIGGERS AND MEDIATORS WELLNESS

  4. Integrative Health and Personalized Medicine: Layers of Data for an Individual Topol et al, Cell 2014 Individualized Medicine from PreWomb to Tomb, Geographic Information System of a Human Being

  5. The P4 Health Spectrum – A Predictive, Preventive, Personalized and Participatory Continuum for Promoting Healthspan Sagner, Michael; et al.Progress in Preventive Medicine2(1):e0002, January 2017. The P4H continuum model. 5

  6. Integrative Medicine: Subclinical Disease Imaging Assessment Environmental Exposure Genomics Advanced Biomarkers Stress & Relationships Nutrition and Lifestyle Comprehensive History and Physical

  7. Advanced Biomarkers 48 year old male with elevated CAC (95 th percentile), on high- intensity statin (Crestor 20 mg) LDL 72 Evidence of Residual Risk Inflammatory markers Prediabetes (A1c 5.8, Fasting Insulin 17)

  8. Advanced Biomarkers Cardiovascular Genomics

  9. J Cell Mol Med. 2008, 12(6b): 2762-2771

  10. Weights are generally assigned to each genetic variant according to the strength of their association with disease risk (effect estimate). Individuals are scored based on how many risk alleles they have for each variant (for example, zero, one, or two copies) included in the polygenic score

  11. Genetics and Lifestyle

  12. Integrative Health Treatment Approach Addressing actionable Advanced Mind-Body genetic biomarker Treatment of Interventions Addressing Nutrition and variations testing, Optimal Medical Subclinical or Toxin ovrerload -Mindfulness/ Lifestyle guidance for Microvascular Management -ApoE Prescriptions Meditation -Chelation Nutriceutical Disease -MTHFR -Acupuncture Therapies -SLOCO1B1

  13. Personalized Nutrition

  14. Results from the pilot intervention study

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