Improving Pa-ent Outcomes with Research: The Appliance of - - PowerPoint PPT Presentation

29/08/2013

Improving ¡Pa-ent ¡Outcomes ¡with ¡Research: ¡ The ¡Appliance ¡of ¡Science ¡ NIHR ¡UCL ¡Hospitals ¡Biomedical ¡Research ¡Centre ¡

¡

Bryan Williams MD FRCP FESC FAHA Professor of Medicine and BRC Director

University College London Hospitals NIHR Biomedical Research Centre

World Class Universities

Unique NHS

Innovation and Enterprise Improved Patient Outcomes

National Institute for Health Research (NIHR)

University College London Hospitals NIHR Biomedical Research Centre

“Creating Health and Wealth…”

Challenges in the Biomedical Research Pipeline

University College London Hospitals NIHR Biomedical Research Centre

• Regulatory Challenges
• Skills Shortage
• Lack of Co-ordinated infrastructure
• Need for Genomics at scale
• Need to Leverage Clinical Data
• Need for open industrial partnership
• Cultural change in

Universities

• Embracing and

Rewarding Enterprise

Drug Development at Risk – Need for a New Model for Partnership with Industry

Pharmaceutical Industry R&D Productivity

University College London Hospitals NIHR Biomedical Research Centre

NIHR Comprehensive Research Network Academic Health Science Centres and Networks Patient and BioInformatics Genomics Phenome Centre University Discovery Science Target Validation NIHR Biomedical Research Centres BRC

University College London Hospitals NIHR Biomedical Research Centre

Discovery, Translation, Innovation, Enterprise

Biomedical Research Centres

• Major Research Infrastructure investment (£100m over 5 years);
• Partnership between University biomedical Science and the NHS;
• Focus on improving the translation of world class fundamental

research into clinical care – unleashing the potential of our leading Universities and the NHS;

• Focus on reinvigorating the UK bioscience industry by providing the

infrastructure to foster partnerships with SMEs and Pharma;

• Focus on experimental medicine – early phase – new drugs, new

diagnostics and therapeutic innovation for our patients - first;

• Seamless transition from early phase research to clinical adoption

and diffusion across the NHS via Academic Health Science Partnerships;

• National bioresourcing and informatics – genomics, proteomics –

real world data linkage – unparalleled world-wide.

University College London Hospitals NIHR Biomedical Research Centre

University College London Hospitals NIHR Biomedical Research Centre

Focus on Experimental Medicine

Cancer Cardiometabolic Infection, Immunity, Inflammation Neurosciences

Education & Capacity Building in Experimental Medicine

UCL Hospitals NIHR Biomedical Research Centre

NHS Patients UCL Science

What is Experimental Medicine ?

“ Usually early phase human studies up to phase IIa, but experimental medicine can be mechanistic studies embedded within later phase studies ….” “Investigation undertaken in humans, relating where appropriate to model systems, to identify mechanisms of pathophysiology or disease, or to demonstrate proof-of-concept evidence of the validity and importance of new discoveries or treatments.” Medical Research Council

University College London Hospitals NIHR Biomedical Research Centre

Experimental Medicine and the Translational Pathway at UCL

University College London Hospitals NIHR Biomedical Research Centre

Discovery / Target Validation First in man evaluation, safety, proof of concept, mechanisms Adoption – Efficacy Diffusion – Implementation / Patient Outcomes

UCL

BRC CRF

CTU UCLP

UCLP

Innovation Office

UCLB / TRO / UCL Enterprise

R e v e r s e T r a n s l a t i

• n

Creating Health and Wealth

Industrial Collaboration Sir Francis Crick Institute Yale – UCL Partnership Cross BRC/BRU Collaboration MRC Chapter – e Health

Accelerate translation

BRC and BRUs

UCLH-UCL NIHR BRC

• Cardiometabolic
• Cancer
• Infection and Inflammation
• Neuroscience

GOSH/Child Health NIHR BRC Moorfields/Ophthalmology NIHR BRC UCLH-UCL NIHR BRU Dementia

Discovery → Proof of concept

UCL Discovery Engine and the Sir Francis Crick Institute

University College London Hospitals NIHR Biomedical Research Centre

Early Phase Clinical Research Facilities

Proof of concept / mechanisms

• Dedicated CRF
• Embedded within the hospital
• Complex Phase I/II study capability
• New Neuroscience CRF at Queen Sq.

University College London Hospitals NIHR Biomedical Research Centre

UCL Partners: Adoption & Translation

• Largest Academic Health

Science Network in Europe;

• Translating, Adopting and

Delivering Biomedical Innovation at scale;

• Facilitating and

Streamlining later phase clinical trials;

• Evaluation at scale

University College London Hospitals NIHR Biomedical Research Centre

Big Data – leveraging the research potential of

• ur patient populations
• UCL FARR Institute is one of four E-Health Informatics

Research Centres funded by the MRC and partners.

• Aims to bring together its partners’ world-class clinical

science, informatics expertise and educational strengths to establish an international centre of excellence in innovative health informatics research, and maximise translational impact for patient benefit.

• National Health Informatics Collaborative (NHIC) – Big

5 BRCs (UCL, Imperial, Kings, Oxford, Cambridge) combine to leverage patient data for researcg

University College London Hospitals NIHR Biomedical Research Centre

Context for Change…..

• NHS “Innovation for Health and Wealth” Agenda;
• Major Government investment in UK Bioscience;
• Key emphasis on leverage and wealth creation;
• Industrial engagement – Pharma, MedTech, Biotech and

SMEs – inward investment

• Enterprise and Entrepreneurship from within;
• Innovation in Health Care; the “value proposition”

University College London Hospitals NIHR Biomedical Research Centre

NIHR University College London Hospitals Biomedical Research Centre

New partnerships…

University College London Hospitals NIHR Biomedical Research Centre

UCL

NHS

UCLH BRCs

What does all of this mean for patients?

• First and often unique access leading edge developments in

medicine;

• Recruitment and retention of world-leading clinicians/academics;
• A culture of excellence and academic rigor that permeates all that

we do;

• An opportunity to tackle fundamental challenges in medicine:
• Examples:
• Treatment Resistant Cancer
• Emerging antibiotic resistance / HIV and epidemic viruses
• Best exploitation of developments in imaging
• Treatments for Dementia
• Better treatment for Stroke

University College London Hospitals NIHR Biomedical Research Centre

Public and Patient Involvement

• We are looking for opportunities to engage with the public and our

patients – this is your BRC

• Help and advice in designing our research projects
• Help and advice in producing appropriate communications with patients and

the public

• Help in developing better ways to communicate our research results and its

impact

• Help with media work
• Help in getting more people involved in research
• Contact Rosamund Yu

Telephone: 020 7679 6166 Email: rosamund.yu@ucl.ac.uk Website: www.uclhospitals.brc.nihr.ac.uk

University College London Hospitals NIHR Biomedical Research Centre

www.uclhospitals.brc.nihr.ac.uk

NIHR University College London Hospitals BRC in the Media

http://www.bbc.co.uk/news/health-22812477

NIHR University College London Hospitals BRC in the Media

http://www.bbc.co.uk/news/health-23312712

Biomedical Research Centre Summary

• Partnership between UCL and the NHS (UCL Hospitals)
• Translating Discovery into patient care: Complex Phenotyping,

Early Phase Evaluation (I/II) and Evaluating Mechanisms of Disease (II-IV);

• Partnership with UCLPartners – Adoption and Implementation at

scale (III/IV);

• A strong spirit of Innovation and Entrepreneurship;
• A new culture of Collaboration and Partnership with industry –

creating health and wealth – a unique opportunity;

• Aligned and explicitly supported by UK Government strategy and

funding – coordinated by the NIHR Office for Clinical Research Infrastructure (NOCRI) nihr.ac.uk/infrastructure/nocri

University College London Hospitals NIHR Biomedical Research Centre