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Enrique Terán MD PhD
On behalf of the RIBEF researchers team
Jose María “Chema” Cantú (+)
Mexican pioneer in Genetics Human Genome Project LA Leader
IberoAmerican Pharmacogenetics Network Red Iberoamericana de - - PowerPoint PPT Presentation
IberoAmerican Pharmacogenetics Network Red Iberoamericana de - - PowerPoint PPT Presentation
IberoAmerican Pharmacogenetics Network Red Iberoamericana de Farmacogentica Enrique Tern MD PhD On behalf of the RIBEF researchers team Jose Mara Chema Cant (+) Mexican pioneer in Genetics Human Genome Project LA Leader TOXICITY
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TOXICITY Slow Metabolizers LACK EFFICACY Ultrarapid Metabolizers
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Interethnical variability: CYP2D6 gene multiplication (Ultrarapids?)
Interethnic distribution of individuals with CYP2D6 gene duplicated
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Adrián LLerena 2016 allerena@unex.es
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RIBEF Activities 2006-2014
Activity Number Countries involved Diffusion of information 322 31 Capacitation of Human resources 101 12 Production of Scientific information 22 13 Guidance to Clinical implementation 1 02 Total 446 31
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Diffusion activities per year
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CEI CEIBA A Con
- nsor
sorcio cio Eur urop
- peo
eo Ib Iber ero
- Amer
merican icano
- Far
armac macog
- gen
enét ética ica Population Pharmacogenetics among Iberoamerican populations N= 6050
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URU POR PER MEX SPA CUB CHI BRA ARG CEIBA Consortium
2016
6050 Volunteers
1384 1824 96 174 2571
Native Americans Caucasians African Americans Ashkenazi Jews Admixed Americans
n=426 n=98 n=294 n=452 n=713 n=528 n=1550 n=133 n=286 n=32 n=1081 n=456
NIC ECU CRI COL
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MESTIFAR: Relationship with ancestry (declare/molecular markers)
PER MEX MEX PER ARG
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IBEROFEN 17IA004
GENES AND METABOLIC PHENOTYPES IN AMERICAN POPULATION Interaction genes-environment on the metabolic phenotype in autochthonous and admixed populations in Iberoamerica
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Pasantías =81 HR exchange =86
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Training = 343 activities
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Publications =51
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