SLIDE 1
W W W . R E G E N C E L L U L A R . N Z
W W W . R E G E N C E L L U L A R . N Z
HOW OUR BODIES CAN HEAL ITSELF W W W . R E G E N C E L L U L A R . N - - PowerPoint PPT Presentation
HOW OUR BODIES CAN HEAL ITSELF W W W . R E G E N C E L L U L A R . N - - PowerPoint PPT Presentation
OPTION C HOW OUR BODIES CAN HEAL ITSELF W W W . R E G E N C E L L U L A R . N Z PLAYED SPORT?? W W W . R E G E N C E L L U L A R . N Z BEFORE W W W . R E G E N C E L L U L A R . N Z ARTICULAR CARTILAGE W W W . R E G E N C E L L U L A R .
SLIDE 2
SLIDE 3
W W W . R E G E N C E L L U L A R . N Z
BEFORE
SLIDE 4
W W W . R E G E N C E L L U L A R . N Z
ARTICULAR CARTILAGE
SLIDE 5
W W W . R E G E N C E L L U L A R . N Z
WHAT’S OSTEOARTHRITIS (OA)
✓ Disease of the whole joint ✓ Osteoarthritis substantially reduces the amount of healthy years of life lived ✓ Fourth leading cause of disability worldwide ✓ No cure ✓ By 2040.. one million people in NZ will have arthritis
SLIDE 6
W W W . R E G E N C E L L U L A R . N Z
RIGHT KNEE 58 YEAR OLD MALE
AFTER
9 MONTHS POST TREATMENT
SLIDE 7
SLIDE 8
W W W . R E G E N C E L L U L A R . N Z
PURE EXPANDED STEM CELL TREATMENT FOR OSTEO & SPORTS INJURIES
✓ Only company in NZ (2 in Australia) using the Pure Expanded Stem Cell protocol (PESC) which allows cartilage to grow ✓ Non-invasive treatment. Can eliminate or delay surgery ✓ We grow a patients own cells in our lab to massive numbers for injection into affected area ✓ We specialise in treatment of osteoarthritis & sports injuries ✓ Our treatment based on successful medical trials ✓ Backed by the Medical Council
PURE EXPANDED STEM CELL THERAPY
SLIDE 9
WHERE DO THEY COME FROM?
✓ Our body fat stores mesenchymal Stem Cells – MSCs ✓ A mesenchymal stem cell is a primitive cell which can differentiate depending on placement ✓ We are interested in MSCs because of their ability to regrow cartilage
SLIDE 10
WHAT CAN STEM CELLS DO?
SLIDE 11
HOW THE TREATMENT WORKS
SLIDE 12
SLIDE 13
W W W . R E G E N C E L L U L A R . N Z
ME Oct 30 2019
SLIDE 14
MEDICATE
CURRENT MEDICAL OPTIONS
OPERATE
SLIDE 15
W W W . R E G E N C E L L U L A R . N Z
REGEN CELLULAR
Kellgren-Lawerence Grading Scale
GRADE 1 GRADE 2 GRADE 3 GRADE 4
CLASSIFICATION NORMAL DOUBTFUL MILD MODERATE SEVERE
SLIDE 16
W W W . R E G E N C E L L U L A R . N Z
STATISTICS OF KNEE OSTEOARTHRITIS
AVERAGE AGE OF DIAGNOSIS OF KNEE OSTEOARTHRITIS
1990s VS 2010Ss
SLIDE 17
W W W . R E G E N C E L L U L A R . N Z
COST OF ARTHRITIS IN NZ 2018
(osteo major component)
Source: Deloitte Access Economics analysis
Health sector costs Other financial costs Loss of wellbeing
$993m
$3.3b
$7.9b
$321m dominated by osteoarthritic knee and hip surgeries. $34.9m cost of GP visits in 2018 due to arthritis $69.5m pharmaceutical bill $210m medical specialists/allied health services (21% of total health cost).
SLIDE 18
PATIENTS ARE EXTREMELY UNSATISFIED:
HIGH UNMET MEDICAL NEED THE VICIOUS CYCLE OF OA KNEE PAIN
Today’s treatment paradigm is trapping patients in a vicious cycle of OA knee pain
19% 91% 59%
Knee OA patients are highly satisfied with their current treatment Not Ready for total knee replacement Will try almost anything prior to surgery
SLIDE 19
REGEN IN THE MEDIA
SLIDE 20
SLIDE 21
W W W . R E G E N C E L L U L A R . N Z
FACING YOUR CRITICS
SLIDE 22
W W W . R E G E N C E L L U L A R . N Z
REGEN MRI RESULTS
BEFORE TREATMENT AFTER PESC TREATMENT CASE 1 KNEE CARTILAGE
SLIDE 23
W W W . R E G E N C E L L U L A R . N Z
EVIDENCE BASED MEDICINE
Results of the world's largest published trial on the benefits of stem-cell therapy for osteoarthritis. MELBOURNE May 28, 2019 Study shows that stem cells can stop the progression of
- steoarthritis and regrow cartilage.
Stem cell therapy improves the quality of life of those affected by more than to 290% Regenerative Medicine Journal
SLIDE 24
Regenerative medicine by the use of cell and gene therapy and tissue engineering has emerged as one of the most exciting
areas of biotechnology, raising hopes for researchers, clinicians, and patients.
Having as its main purpose the regeneration of injured tissue and not its replacement with an external device, advances in
this field may avoid treatments based on grafts and artificial prostheses.
Regenerative medicine offers the possibility of personalization and to treat multi-factorial diseases such as osteoarthritis.
October 23, 2019
SLIDE 25
W W W . R E G E N C E L L U L A R . N Z
REGEN CLINICAL TRIAL 2020
First clinical trial between academic institution and stem cell company in Australasia
SLIDE 26
W W W . R E G E N C E L L U L A R . N Z
“WITCHCRAFT” “HOCUS POCUS”
SLIDE 27
W W W . R E G E N C E L L U L A R . N Z
REGEN RESULTS
KNEES Over 90% SHOULDERS 80% HIPS 80%
HANDS, ANKLES, WRISTS 70%
Patient mean age: 48-82 years
Response rate for PESC in cartilage and tendon repair
SLIDE 28
BUT STEM CELLS ARE EXPENSIVE RIGHT?
HIP $25-30,000 (ONE) KNEE $22-26,000 (ONE) HIP $12,500 (ONE) $15,000 (TWO) KNEE $12,500 (ONE) $15,000 (TWO) PESC TREATMENT REPLACEMENT SURGERY
SLIDE 29
OWEN FRANKS
SO IS THIS THIS IS OWEN FRANKS
SLIDE 30
SLIDE 31
W W W . R E G E N C E L L U L A R . N Z
JASON HIPS
JAN 2018 OCT 2018
SLIDE 32
SLIDE 33
W W W . R E G E N C E L L U L A R . N Z
REGEN CELLULAR
SLIDE 34
SLIDE 35
W W W . R E G E N C E L L U L A R . N Z
KEEP IN THE FACES OF OUR BIGGEST CRITICS MAKE OUTCOMES RELATABLE TELL GOOD STORIES PUSH
SLIDE 36
Martine Rothblatt
─ Too 100 business minds ─ Highest paid US female CEO ─ Futurist
SLIDE 37
W W W . R E G E N C E L L U L A R . N Z
“Persistence is omnipotence”
Martine Rothblatt
CEO United Therapeutics
SLIDE 38
FUTURE Healthcare Revolutions Report By 2040
✓ Personalised medicine ✓ Stem cell medicine ✓ Nano-scale medicine ✓ Gene therapy and editing ✓ Digital health
Ray Hammon
Futurologist
SLIDE 39
W W W . R E G E N C E L L U L A R . N Z
HOPE 92 YEAR OLD PATIENT
SLIDE 40