Dr. Bjrn Jensen Klinik fr Gastroenterologie, Hepatologie und - - PowerPoint PPT Presentation

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Dr. Bjrn Jensen Klinik fr Gastroenterologie, Hepatologie und - - PowerPoint PPT Presentation

Nov 04, 2023 303 likes •596 views

AREVIR 04.05.2019 Analytic treatment interruption after allogeneic CCR5-D32 HSCT for AML in 2013 Update Dr. Bjrn Jensen Klinik fr Gastroenterologie, Hepatologie und Infektiologie Universittsklinikum Dsseldorf *1969, m HIV diagnosed

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AREVIR 04.05.2019

Analytic treatment interruption after allogeneic CCR5-D32 HSCT for AML in 2013

Update

  • Dr. Björn Jensen

Klinik für Gastroenterologie, Hepatologie und Infektiologie Universitätsklinikum Düsseldorf

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  • HIV diagnosed 10/2010; MSM;

started with TDF/FTC+DRV/r

  • Diagnosis of AML (acute myeloic leukemia, inv16, CBF-MYH11)

in 01/2011

*1969, m

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  • verview I
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  • verview II
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  • verview III
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Overview IV

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Overview V

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  • GALT
  • lymph nodes
  • Liquor/CNS/CSF
  • urogenital tract
  • follicular

dendritic cells

  • macrophages
  • resting CD4+

cells

„Can HIV be cured?“ Mario Stevenson Scientific American 299, 78 - 83 (2008)

HIV reservoirs

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Virology I

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HIV DNA in GALT

Yukl et al., JID 2010

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Virology II

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mVOA

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Virology III

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Tropism phänotypically (TROPChase)

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Serology I

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Serology II

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Immunology: HIV-1-specific CTL

(C. Mummert, S. Bergmann, T.Harrer)

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Next talk

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Serology II

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Lymph node

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  • M. Bruner et al, 2015
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Histology lymph node

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Overview

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Conclusion

  • > 6 years after HSCT, almost 6 months ATI
  • Examining the reservoir and interpreting the results is challenging
  • ATI is the only way to validate long-term remission (cure?)
  • Currently HI-VL 2x/week, every 2 weeks larger blood draws (incl.

Immunology)

  • Until now all blood samples negative, patient feels well
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Diskussion