Tuberculosis Mark Oette Klinik fr Allgemeine Innere Medizin, - - PowerPoint PPT Presentation

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Apr 05, 2023 255 likes •513 views

Tuberculosis Mark Oette Klinik fr Allgemeine Innere Medizin, Gastroenterologie und Infektiologie Krankenhaus der Augustinerinnen, Kln Conflicts This presentation is free of financial interests Speech honoraria of the last 3

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Mark Oette Klinik für Allgemeine Innere Medizin, Gastroenterologie und Infektiologie Krankenhaus der Augustinerinnen, Köln

Tuberculosis

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This presentation

is free of financial interests

Speech honoraria of the last 3 years

BMS Falk Gilead Heinen & Löwenstein Hitachi Krankenhäuser

Conflicts

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Tbc worldwide

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Europe: Transm issible Diseases

Inzidence-based DALY/ 100.000, 2009-2013 (1.4 Mio, every 14th person)

Cassini A. Eurosurveillance 2018; 23: pii= 17.00454

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Europe: Tbc Notification Rate

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Tuberculosis Incidence Germany (RKI 2018)

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Lung Tbc and Nationality (RKI 2015)

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Nationality: Italy

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Tuberculosis, Age, and Gender (RKI 2018)

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Diagnostics (RKI 2015)

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Mortality (RKI 2018)

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Resistance (RKI 2018)

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Resistance: Italy

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Resistance (RKI 2018)

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Lange C, et al. Respirology 2018; 23: 656-673

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Resistance (MDR)

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Europe: Tbc MDR-Rate

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Evaluation of 5 software tools to predict resistance (n= 211), 2014
Comparison with growth cultures/ phenotypic resistance testing
WGS: Illumina MiSec System
Software tools :

PhyResSE, Mykrobe Predictor, TB Profiler, TGS-TB and KvarQ

Results:

Sensitivity: 74-80% ; Specificity: > 95% Considerable variation between individual drugs Turnaround time (median): 5 vs. 19 days

Van Beek J. Clin Microbiol Infect 2019; 25: 82-86

Sequencing for Resistance Mutations

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In Germany approx. 5500 affected persons, slow decline
Epidemiology still driven by migrants
Resistance: Significant problem, rising (not in G)
Transmission of resistance
MDR: Relevant for survival
Resistance testing: Procession time suboptimal
Molecular resistance testing:

New applications underway

The future: Resistance testing by NGS standard

Summary

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Thank you !

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