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AREVIR, 05.05.2018 RESINA 2001-2018 Dr. Bjrn Jensen Klinik fr Gastroenterologie, Hepatologie und Infektiologie Universittsklinikum Dsseldorf The RESINA Study (Genotypic HIV-Resistance in Treatment-Naives) Ongoing prospective study

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RESINA 2001-2018

  • Dr. Björn Jensen

Klinik für Gastroenterologie, Hepatologie und Infektiologie Universitätsklinikum Düsseldorf

AREVIR, 05.05.2018

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The RESINA Study

(Genotypic HIV-Resistance in Treatment-Naives)

  • Ongoing prospective study in Nordrhein-Westfalen
  • Inclusion: Untreated HIV-infected subjects before ART initiation
  • Study period: 2001-2018
  • Aims of study:

– Epidemiology of primary resistance in chronically HIV-infected

patients

– Evaluation of efficacy of HAART guided by resistance testing – Bioinformatic analysis of resistance data – Subgroup analyses

  • Classification of resistance: Shafer RW et al., Antiviral Therapy 2009
  • Until end of April 2018: 4423 patients in 36 centers, 3846 analyzed in this

presentation

  • Funding:

– Federal Ministry of Health and Social Security (BMG) – Heinz-Ansmann-Foundation for AIDS-Research

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RESINA 2001-2018 Nationality

Deutschland 71,87

  • ther

13,60 Türkei 1,95 Thailand 1,48 Kamerun 1,43 Kenia 1,40 Russland 1,25 Togo 1,04 Polen 1,04 Ghana 1,01 Nigeria 0,96 Italien 0,86 Kongo 0,62 Brasilien 0,60 Griechenland 0,49 Portugal 0,39

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RESINA 2001-2018 Subtypes men, 80,1 %

B 2458 A 236 02_AG 125 C 47

  • ther CRFs

61

  • ther

49 G 32 D 22 n.d. 23

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SLIDE 5

RESINA 2001-2018 Subtypes women 18.7%

B 200 A 172 02_AG 114 C 64

  • ther CRFs

27

  • ther

22 G 37 D 35 n.d. 5

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SLIDE 6

RESINA 2001-2018 Transmission risks men

MSM 65,65 heterosexual 13,88 unknown 9,64 IVDA 5,08 pattern II 4,21 bisexual 0,87 blood transfusion 0,29

  • ther

0,39

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RESINA 2001-2018 Transmission risks women

heterosexual 45,42 pattern II 34,44 IVDA 9,86 unknown 8,19 blood transfusion 0,97

  • ther

1,11

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TDR 2001-2018

5 10 15 20 25 2001 (86) 2002 (101) 2003 (124) 2004 (220) 2005 (218) 2006 (250) 2007 (358) 2008 (374) 2009 (290) 2010 (331) 2011 (261) 2012 (247) 2013 (239) 2014 (238) 2015 (166) 2016 (145) 2017 (157) 2018 (40) NRTI NNRTI PI INI any

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RESINA 2001-2018 Summary

  • The RESINA study provides a diverse and representative study

cohort

  • Non-B-subtypes are present in about 20% of men and 75% of

women in our cohort

  • Detailed analyses regarding TDR, epidemiology and

subgroups are planned

  • 808 patients with therapy-naive and 433 patients with post-

treatment integrase sequences are already included in the database

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RESINA-Study Centers

Praxis Arbter, Krefeld Praxis Baumann, Neuss Praxis Becker-Boost, Duisburg Praxis Busch, Christenen, Münster Praxis Carls, Huber, Düsseldorf Praxis Dresch, Köln Uniklinik Essen, S. Esser Uniklinik Köln, G. Fätkenheuer Praxis Ferdinand, Köln Praxis Gantke, Düsseldorf Praxis Gippert, Hartmann, Quaing, Münster Praxis Grüneberg, Münster Praxis Radecki, Köln Klinikum Dortmund, M. Hower, Dortmund Praxis Isernhagen, Römer, Qurishi, Köln Praxis Knechten, Habets, Aachen Praxis Köthemann, Neuwirth, Köln Praxis Kwirant, Duisburg Praxis Mauruschat, Wuppertal Praxis Mauss, Schmutz, Hegener, Düsseldorf Praxis Miasnikov, Düsseldorf Krankenhaus der Augustinerinnen, M. Oette, Köln Klinikum Osnabrück, A. Mutz Uniklinik Düsseldorf, B. Jensen, T. Feldt, D. Häussinger Praxis Reith, Düsseldorf Klinik Kemperhof, A. Rieke, Koblenz Uniklinik Bonn, J. Rockstroh Praxis Schäfer, Bielefeld Praxis Schoelzel, Troisdorf Praxis Scholten, Köln Krankenhaus Hagen, T. Scholten, Hagen Praxis Schons, Düsseldorf Praxis Schuster, Wuppertal Praxis Stechel, Juretzko, Köln Praxis Strehlow, Petry, Düsseldorf Praxis Wiesel, Theisen, Voigt, Köln

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SLIDE 11

Jasmina Bogojeska Kasia Bozek Joachim Büch Glenn Lawyer Alejandro Pironti Alexander Thielen André Altmann Niko Beerenwinkel Francisco Domingues Kirsten Roomp Jörg Rahnenführer Hiroto Saigo Oliver Sander Tobias Sing Matthias Döring Francesca Incardona Mattia Prosperi Michal Rosen-Zvi Anders Sönnerborg Maurizio Zazzi

Weitere Kooperationspartner

Ricardo Camacho Francesca Ceccherini-Silberstein Buonaventura Clotet Manon Eckhardt Richard Harrigan Hans-Georg Kräusslich Barbara Müller Jean Claude Schmit Robert Shafer Valentina Svicher Annemie Vandamme Patrick Braun Stefan Esser

Gründungsteam

Daniel Hoffmann Jochen Selbig Jürgen Klein Eberhard Schrüfer Rolf Kaiser Florian Klein Martin Däumer Melanie Balduin Saleta Sierra Aragon Jens Verheyen Finja Schweitzer Elena Knops Susanna Trapp Eva Heger Maria Neumann Fraune Claudia Müller Eugen Schülter Michael Böhm Angelika Hergesell Dörte Hammerschmidt Anna Marie Sikorski Frank Wilhelm Klaus Remmel Tobias Nolden Ibrahim Boussaad Dieter Häussinger Mark Oette Stefan Reuter Björn Jensen Falk Hüttig André Fuchs Ulrike Haars Ralf Winzer Steffi Göbels Arne Kroidl Ruth Petch

Genafor e.V./ HIV-Grade

Thomas Berg Patrick Braun Gerd Fätkenheuer Klaus Korn Jürgen Rockstroh Barbara Schmidt Hauke Walter Benedikt Weissbricht Martin Obermeier Martin Stürmer

Heinz-Ansmann-Stiftung

Jörg Timm Nadine Lübke

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SLIDE 12

Vielen Dank für die Aufmerksamkeit !