Cirads Platform in Partnership (GREASE) Activities on Zoonoses in - - PowerPoint PPT Presentation
Cirads Platform in Partnership (GREASE) Activities on Zoonoses in South East Asia J. CAPPELLE, A. BINOT, V. CHEVALIER, M. DESQUESNES, R. DUBOZ, F. GOUTARD, S. MORAND, M. PEYRE and F. ROGER 70% of Emerging Infectious Diseases are Zoonoses
PEYRE and F. ROGER
Global emerging zoonotic pathogens from wildlife hotspots (Jones et al, Nature, 2008)
Nipah virus (NiV) Severe Respiratory Acute Syndrome (SRAS) virus Highly Pathogenic Avian Influenza (HPAI) virus
Bordier & Roger 2013 Jones et al 2008
Réunion - Mayotte West Indies-French Guiana
Ile de France Languedoc- Roussillon Continental Southeast Asia Southeast Asian islands East and Southern Africa Continental West Africa Coastal West Africa Central Africa Madagascar Brazil Mediterranean Latin America
12 regional offices in the French overseas regions and abroad A scientific hub in Montpellier 700 staff members based outside metropolitan France Researchers assigned to 40 countries Collaborative projects in 90 countries
4 CIRAD Research Units: Eco/Epi (AGIRs), Animal Prod, Lab. and Trypanosomiasis and collaborations with other units in the fields of mapping, sociology, modelling etc.
Conservation Fundation
GIS Engineer & Modeller
SOCIOLOGIST GEOGRAPHER
PPR CBPP LSD BT FMD ASF NCD bTB Bruc RVF WN(EJ) Crypto Priorization Epidemiology Surveillance Modelling Ecology SHS Economic study Risk Analysis Epidemiology Ecology SHS Risk Analysis Modelling Epidemiology Risk Analysis Modelling Economic study Avian/Swine Influenza (Nipah) (Rabies)
Mediterranean Wildlife/Human RP-PCP Wildlife/Human/Domestic
NaVRI (Cambodia) NuOL (Lao PDR) CMU (Philippines) KU (Thailand) Presidency (>2014) NIVR (Vietnam) Cirad (SEA) Coordination (>2014) 6 core members SEA (MoU) + 9 associated partners (Regional, International, Thais & French) Institut Pasteur (Cambodia), Univ. Gadjah Mada (Indonesia), AIT, OIE, FAO RAP,
University (Thailand) IRD, CNRS
+ Extension to Malaysia, China as key partners for emergence management
Researchers/ Experts Communities/ Notables Decision makers
Specific Syndroms & diseases: Diseases surveillance & control
Beyond official surveillance reporting networks Cartography & measure relationships and interactions between peoples, groups, entities
Specific Syndroms & diseases: Bats & Rodent borne diseases…
Specific Syndroms & diseases: Influenza (swine & avian)
E-learning
Trainings: participatory epidemiology, biostat R Master degree/PhD (InterRisk)
Training & Education
Capacity of surveillance systems to detect zoonotic epidemics Evaluation of surveillance systems in animal (Peyre et al. 2011) Capture-recapture methods (Vergne et al. 2012) Probabilistic approaches to optimize the detection of a disease (Goutard et al. 2012) Systemic analysis of surveillance and control (Collineau et al. 2013) Participatory approaches and socio-economic issues (Delabouglise et al. 2012) Introduction of costing methods within simulation (Duboz 2012) References
Collineau L, Duboz R, Paul M, Peyre M, Goutard F, Holl S, et al. (2013). Application of loop analysis for the qualitative assessment of surveillance and control in veterinary epidemiology. Emerging Themes in Epidemiology 10:7. Delabouglise A, Antoine-Moussiaux N, Phan Dang T, Nguyen Tien T, Dao Cong D, Dao Thi H, et al. (2012). The use of participatory approaches to evaluate the socio-economic factors impairing the efficacy of animal health surveillance systems. 13th International Symposium on Veterinary Epidemiology and Economics, Maastricht, Netherlands Duboz R (2012). Weighted Activity and Costing of Surveillance and Control in Animal Epidemiology. In the proceedings of Activity-Based Modeling & Simulation ACTIMS’2012, Cargese, France Goutard F, Ponsich A, Ly S, Allal L, Holl D, Dab W, et al. (2012a). A ‘One Health’ approach to quantitatively compare human and animal surveillance systems for avian influenza H5N1 in Cambodia. International Symposia on Veterinary Epidemiology and Economics proceedings, ISVEE13: Proceedings of the 13th International Symposium on Veterinary Epidemiology and Economics, Belgium, Netherlands Peyre M, Zahhaf A, Figuie M, Binnot A, Bonnet P, Goutard F, et al. (2011). Socio-Economical Evaluation of Surveillance Systems for Emerging Animal Diseases: Merging Veterinary and Public Health Issues. EcoHealth 7:S50-S51. Vergne T, Grosbois V, Durand B, Goutard F, Bellet C, Holl D, et al. (2012). A capture-recapture analysis in a challenging environment: Assessing the epidemiological situation of foot-and-mouth disease in Cambodia. Preventive Veterinary Medicine 105:235-243.
Main results Virus has circulated in 2137 sub-districts Only 779 detected Se of surveillance at sub-district level at the time (2004-2005)= 37% IAHP H5N1 outbreaks might have been understimated around Bangkok area
Figure: Distribution of false-negativesprobabilities Vergne et al. Zero-inflated regressions for assessing the efficiency of highly pathogenic avian influenza (H5N1) surveillance in Thailand .
Mathilde Paul et al Risk map chicken breeding AI diffusion risk map
1. Risk maping HPAI H5N1- Thailande
factors → Paul et al. SVEPM proceedings 2010 → Paul et al. Vet Res 2010
2. Multi Criteria Decision Making (MCDM) on AI factors
– Thailande (data + maps); validation with outbreak maps – extension Cambodge, Laos, Vietnam
Wildlife-livestock-human interface: Emergence of zoonoses Rodent-borne diseases: identification of areas with possibly a higher risk Bordes et al. 2013
Bordes F, Herbreteau V, Dupuy S, Chaval Y, Tran A, and Morand S (2013). The diversity of microparasites of rodents: a comparative analysis that helps in identifying rodent-borne rich habitats in Southeast Asia. Infection ecology & epidemiology 3. Jiyipong T, Morand S, Jittapalapong S, Raoult D, and Rolain J-M (2013). Bordetella hinzii in rodents, Southeast Asia. Emerging Infectious Diseases 19:502-503.
new zoonotic pathogens Jiyipong et al. 2013
Interesting model to implement interdisciplinary studies Spillback transmission of H1N1p virus from humans to animals (Trevennec et al. 2012; Rith et al. 2013) Perception of risks by local communities (Figuie and Fournier 2008; Goutard et al. 2012a). Evaluation of vaccination in Vietnam (Desvaux et al)
Figuie M, and Fournier T (2008). Avian influenza in Vietnam: Chicken-hearted consumers? Risk Analysis 28:441-451. Goutard FL, Paul M, Tavornpanich S, Houisse I, Chanachai K, Thanapongtharm W, et al. (2012b). Optimizing early detection of avian influenza H5N1 in backyard and free-range poultry production systems in Thailand. Preventive Veterinary Medicine 105:223-234. Rith S, Netrabukkana P, Sorn S, Mumford E, Mey C, Holl D, et al. (2013). Serologic evidence of human influenza virus infections in swine populations, Cambodia. Influenza and Other Respiratory Viruses 7:271-279. Trevennec K, Leger L, Lyazrhi F, Baudon E, Cheung CY, Roger F, et al. (2012). Transmission of pandemic influenza H1N1 (2009) in Vietnamese swine in 2009-2010. Influenza and Other Respiratory Viruses 6:348-357.
International research network “One Health”
Zoonosis in Southeast Asia
University/ENVT)
dialogue facilitation for “One Health”
Kasetsart University 28
29
Kasetsart University
Kasetsart University 30
31
32
To integrate social and economical aspects in the activities
To identify and analyze health risks To choose and use appropriate tools in a decision-making perspective Complementary skills To set up a surveillance system To set up a control program To set up risk prevention activities
33
Professional integration
Public sector International Organisations Private sector
FETPV Field epidemio
Thai Thai Vet
French Vet
Research
Internationa l Students
Thai
34
35
36
37
38
www.cirad.fr/en
www.grease-network.com