Cervical spinal cord normal-appearing white matter tissue integrity - - PowerPoint PPT Presentation

Cervical spinal cord normal-appearing white matter tissue integrity progression correlates with sensorimotor functional changes in multiple sclerosis

Joo-won Kim1, Xi Yang1, Eric C. Klawiter2, Samantha Lancia3, Sheng-Kwei Song3, Anne H. Cross3, Robert T. Naismith3, Junqian Xu1

1Icahn School of Medicine at Mount Sinai 2Massachusetts General Hospital 3Washing University in St. Louis

2/1/2018

Disclosures

• A. H. Cross: Consulting for AbbVie, Bayer, Biogen, EMD

Serono, Genentech/Roche, Genzyme/Sanofi, Novartis, Teva.

• R. T. Naismith: Consulting for Acorda, Alkermes, Biogen,

Genentech, Genzyme, EMD Serono, Novartis, Teva.

• J.-W. Kim, Y. Xi, E.C. Klawiter, S. Lancia, S.-K. Song, and J.

Xu have nothing to disclose

Previous cross-sectional study

• Naismith et al. 2013, Neurology
• NMO and MS
• DTI radial diffusivity in posterior column (PC)

~ functional assessments

acute

• nset

Longitudinal study

• Patients visit: acute onset, 1, 3, 6, 12, up to 24 months
• At each visit
• Functional assessment
• MRI: T2w, STIR, and DTI
• 7 RRMS patients (age 36, 5 female, EDSS 2.4)
• Lesion identification
• Sagittal STIR or T2w
• Axial b0
• DTI measurements
• Average across slices within tract
• Separate average
• Lesion
• Normal-appearing tissue

STIR acute

• nset

1 month 1 year b0 Xu et al. 2013, NeuroImage

Change of Radial Diffusivity in Normal-Appearing Posterior Column ~ Change of Sensory Function

r = 0.39, p = 0.02

Change of Radial Diffusivity in Lesion Posterior Column

Summary

• Normal-appearing tissue integrity progression, not lesion
• Sensory function, not motor
• Radial diffusivity: highest correlation
• Poster P126, 6 pm today

Acknowledgement

• NMSS: FG-1606-24492 (J-WK), RG4009 (AHC), FG1782 (JX)
• NIH: P01NS059560 (AHC), K24RR017100 (AHC),

R01NS047692 (S-KS), K23NS052430-01A1 (RTN), UL1RR024992 (ECK)