Cervical spinal cord normal-appearing white matter tissue integrity progression correlates with sensorimotor functional changes in multiple sclerosis Joo-won Kim 1 , Xi Yang 1 , Eric C. Klawiter 2 , Samantha Lancia 3 , Sheng-Kwei Song 3 , Anne H. Cross 3 , Robert T. Naismith 3 , Junqian Xu 1 1 Icahn School of Medicine at Mount Sinai 2 Massachusetts General Hospital 3 Washing University in St. Louis 2/1/2018
Disclosures • A. H. Cross : Consulting for AbbVie, Bayer, Biogen, EMD Serono, Genentech/Roche, Genzyme/Sanofi, Novartis, Teva. • R. T. Naismith : Consulting for Acorda, Alkermes, Biogen, Genentech, Genzyme, EMD Serono, Novartis, Teva. • J.-W. Kim , Y. Xi , E.C. Klawiter , S. Lancia , S.-K. Song , and J. Xu have nothing to disclose
Previous cross-sectional study • Naismith et al. 2013, Neurology • NMO and MS • DTI radial diffusivity in posterior column (PC) ~ functional assessments
Longitudinal study • Patients visit: acute onset, 1, 3, 6, 12, up to 24 months • At each visit • Functional assessment • MRI: T2w, STIR, and DTI • 7 RRMS patients (age 36, 5 female, EDSS 2.4) acute onset • Lesion identification • Sagittal STIR or T2w STIR b0 • Axial b0 • DTI measurements Xu et al. 2013, NeuroImage • Average across slices within tract • Separate average • Lesion • Normal-appearing tissue acute 1 1 month year onset
Change of Radial Diffusivity in Normal-Appearing Posterior Column ~ Change of Sensory Function r = 0.39, p = 0.02
Change of Radial Diffusivity in Lesion Posterior Column
Summary • Normal-appearing tissue integrity progression, not lesion • Sensory function, not motor • Radial diffusivity: highest correlation • Poster P126, 6 pm today
Acknowledgement • NMSS: FG-1606-24492 (J-WK), RG4009 (AHC), FG1782 (JX) • NIH: P01NS059560 (AHC), K24RR017100 (AHC), R01NS047692 (S-KS), K23NS052430-01A1 (RTN), UL1RR024992 (ECK)
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