02/02/2017 1 Scie ientifi ntific c Ani nimal l Food od & - - PowerPoint PPT Presentation

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02/02/2017 1 Scie ientifi ntific c Ani nimal l Food od & - - PowerPoint PPT Presentation

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1 02/02/2017 1 Scie ientifi ntific c Ani nimal l Food od & En Engin ineering eering. 2009-2010 INVIVO NSA is created with the 2003 merger of the Animal Nutrition UAR is spited in 2 businesses. 1996 and Health businesses of

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Scie ientifi ntific c Ani nimal l Food

  • d & En

Engin ineering eering.

1956 UAR (is founded Usine d’Alimentation Rationnelle) By Raymond HUARD 1996 GUYOMARC’H NA acquires OFTEL group 2000 GUYOMARC’H NA (just renamed EVIALIS) acquires UAR Brand of Lab animal diet business becomes SAFE. 2003 UAR is spited in 2 businesses. SAFE SAS is created as a new company, dedicated to the Lab Animal Nutrition 2004 SAFE business is transferred in Augy after a full refurbishing and enlargement of an Oftel plant. This New site is, since then, dedicated to the Lab Animal Diet production. 2009-2010 INVIVO NSA is created with the merger of the Animal Nutrition and Health businesses of InViVo and Evialis. SAFE becomes an INVIVO NSA subsiduary. 2013 SAFE is again an independent

  • company. Logo updated.
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  • For over 45 years, UAR, based in the Paris region, has invested in the research

sector.

  • In 2000, UAR, conscious of the industrial challenges to be met to consolidate its

future, preferred to let its business to the (former EVIALIS group), which then became:

SAF AFE : Scientific Animal Food & Engineering.

  • In 2004, SAFE opened a new industrial plant in Augy (close to Auxerre, Burgundy),

fully dedicated to lab animals (unique in Europe).

  • The accumulated experience combined with the group expertise has resulted in

SAFE becoming a reference company in nutritional engineering for lab animals.

SAF AFE th E throu

  • ugh

gh the the yea years rs

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  • In 2008, SAFE plant is certified ISO 14001
  • In 2012, SAFE signed several partner agreements with Asian retailers
  • In

2013, SAFE becomes an independent company. SAFE changed its shareholders, from InViVo NSA to Capital Croissance (innovation and small caps investment funds), Unigrains (Agro Food Funds), BNP-Paribas PE and SAFE’s Management.

SAFE has a 55 years experience in lab animal nutrition, providing Pharmaceutical industries, CRO, Biomedical research centres, breeding facilities in over 25 countries and over 400 direct customers,.. a wide dealer’s network….

SAF AFE th E throu

  • ugh

gh the the yea years rs

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Interactions Dialogue

Nutrients Feed & Food Genes & DNA Nutrients : ignition or extinction vs genes & tissues

WE ARE WHAT WE EAT

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In bi n biom

  • med

edic ical al re resea earc rch, h,die iets ts, , ge gene neti tics an and en envi vironment ronment are are li link nked ed

All must be totaly reliable Stable Diet Base + Stable Environment + Stable Gene Pool = Reliable Study Bases

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Sta Stable ble Die Diets ts

Same Origin, Same Quality, contaminant presence mastered. The product you buy today will be the same tomorrow

+

Guaranting you that we do what we’ve said

+

A stable and safe diet base all along your studies

=

Stable process Fixed formula Stable ingredients

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Con

  • nta

taminants minants com

  • mmu

munly nly pre rese sent nt in in a nor a norma mal l fee feed

From process (acrylamide,neoformed,..) Heavy Metals Pesticides Drugs Bacteria, Fungus e Vírus Micotoxins Phyto-

  • estrogens

Radioactive components Additives in Plant

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Cross Contamination

Authorized level of cross contamination

for non target animal feed species (i.e lab diet)

Impact on your research studies (via lab diet) With other species diets

No Limit

Warning/Danger With diets containing Antibiotic agent

1 %

Warning/Danger With diets containing ionophore coccidiostat agent

3 %

Warning/Danger

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Commitment n° 1

Augy industrial site entirely dedicated to the lab activity

Commitment n° 2

No use of animal nutrition additives: binders, preservatives, drugs, coccidiostats, flavorings, colorings, anti

  • xidants...

Commitment n° 3

Food industrial standard (no farm standard) High quality raw materials

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What "you don't see" is, for example, the digestibility of each ingredient in the recipe, nutritional balance, undesirable substances (mycotoxins, pollutants, doping agents such as morphine, phytoestrogens, drug type products, radioactivity, etc.). Health and veterinary risks must naturally be added to these. Concerning diets, the important thing is not what you see (type of diets, colour..), but what you don't see !

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  • SAFE does not use straw cereals

for farm animals but only cereals used for Baby Food.

PESTICIDES HEAVY METALS MYCOTOXINS

Wh What at c cho hoic ice fo e for the r the ing ingred edie ients nts use used i d in t n the he die diet? t?

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  • The

industry also applies economical

  • ptimisation
  • f diet formulae : the most expensive ingredients are

replaced according to price changes with cheaper ingredients, without changing the values shown on your label (proteins, glucides, energy, etc.) or specifically informing the customer. SAFE diets are made with the same fixed formulas, from the same source (Augy plant) and the same ingredients. At SAFE, this practice is completely prohibited. It would completely change your diets (difference in digestibility, appetizing factors, balance) and create a major bias in your studies which would no longer be comparable over time.

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  • In order to secure your

experiments, SAFE maintain a process control that grant of traceability and consistency of our products Consistency Cross contaminations Traceability

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SAFE’s Organization chart

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Breeding Maintenance

SAFE FE Rodent Rodents die s diets ts ran ange ge

Vegetal Breeding Vegetal Maintenance

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Unique Aging

SAFE FE Rodent Rodents die s diets ts ran ange ge

Unique Vegetal Transgenics

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SAF AFE Die E Diets ran ange ge

Rabbits Guinea Pigs Minipigs & Fowls

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SAFE AFE Di Diet ets r s ran ange ge

Dogs Primates Cats & Zebra

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A30 A40 127 307 326 D03 D04 D05 A03 A04 105 110 112 D113 107 125 CAVIAR 106 114 F86 115 150 D30 D40 D131 A05 R01T-10 R03T25

Irradiated >10/25/40 kGy Autoclavable Double Bag Vacuum Packed 1kg - 5kg - 10kg Certified-Control

Die Diets ts f for

  • r a

all ll La Labo borat ator

  • ry Anim

y Animal als

2 mm 3 mm

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Pap aper erBa Bags gs

Certified Diet Double Paper Bag Irradiated Diet Double paper Bag Standard Diet Paper Bag Autoclavable Diet Paper Bag

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Ea Easy syOp Open en Pap aper erBa Bags gs

Easy Open Paper Bag

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Do Double uble pa pape perba bag

Double Paper Bag

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SP P SP Pac acka kagin ging

Easy open Paper Bag In Plastic Pouch

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Boxes Pallet 2x5kg Box 10x1kg Box 1x10kg Box Beddings packaging

Vac acuume uumed P d Pac acka kagin ging

Easy Vacuum packaging Control

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  • The Shelf-life dates for SAFE diets are :
  • 1 year for diets packed in bags
  • 2 years for vacuum-packed diets

All SAFE diet packaging is identified by various traceability items: product name, production batch, time and best before date. The label also gives composition details in 6 languages: a list of ingredients in decreasing order, nutritional guarantees and production site accreditation number.

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Ma Maste stered ed I Irr rrad adia iatio tion Proc n Process

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Con

  • ntroled

troled / / Cer ertif tifie ied d Di Diet ets

Certified Diets – 162 Analitical controls

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Con

  • ntrole

troled / C d / Cert rtif ifie ied d D Die iets ts

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  • Over 35.000 analysis performed per year,
  • Over 700 different criteria monitored,
  • 500 criteria on final products
  • 200 criteria on ingredients
  • An average of 140 analysis per batch,

SAF AFE E i is : s :

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Nu Nutr trit ition ional al Con

  • nst

stancy ancy

5 Years Samples* 5 Years average* 5 Years Standard deviation* Variation Coefficient (%) Analytical Uncertaincy (+/- or %) GV SOLAS limits** EU Regulations Limits*** A03 Proteins A03 Lipids A03 Potassium A04 Proteins A04 Lipides A04 Potassium

10 10 10 35 34 33 21.50 % 5.15% 8582ppm 15.90% 3.06% 6172 ppm 0,43 0,24 523 0,43 0,27 404 2 4.7 6.1 2.7 8.8 6.5 +/- 0.6 +/-1 10% +/-0.6 +/-1 10% [19.5 ;24.5]% [4.35 ;6.35]% [7295 ;10513]ppm [14.31 ;18.29]% [2.26 ;4.26]% [5172 ;7672]ppm [18.81 ;24.19]% [4.15 ;7.15]% [6582 ;12582]ppm [14.1 ;18.1]% [2.06 ;5.06]% [4172 ;10172]ppm

* Sources SAFE **threshold calculated in accordance with GV-SOLAS, Guidelines for the Quality - Assured Production of Laboratory Animal Diets, EN A-06-2002 ***threshold calculated in accordance with RÈGLEMENT (CE) N o 767/2009 DU PARLEMENT EUROPÉEN ET DU CONSEIL du 13 juillet 2009

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Cust Custom

  • m Die

Diets ts

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Ge Gel Di l Diet ets Ra s Range nge

Gel dietBreeding Gel dietEnergy Gel dietTransport Gel dietWater New Gel dietHigh fat Gel diet125C (dog)

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Be Beddin ddings gs

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En Enric richm hmen ents ts

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ISO 14001

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ISO 9001

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FDA

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Commitments certification

GLP & GMP related

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HACCP Codex Alimentarius

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ISO 14001 ISO 9001 FDA

Commitments certification

GLP & GMP related

HACCP Codex Alimentarius

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REFERENCES

Cancerology / Toxicology Aterosclerosis / Hypertention Gastroenterology/ Hepatology Cellular and Molecular Biology Neurology / Psycology Health / Infectious deaseses

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PROCESS & TOOLS

  • ISO 9001/14001/HACCP Certified industrial site / FDA
  • Production site uniquely dedicated to laboratory animal

diets

  • Total traceability system (from output to input batch/input

to output batch)

  • Baby food type process
  • New site, complying with the most recent agribusiness

standards

  • Optimized industrial pasteurizatin system (Ctis)
  • Manufacture via multi-activity subcontractors

Yes Yes Yes Yes Yes Yes No

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LAB DIETS

  • Cross-contamination (foodstuffs, microorganism etc.)
  • No GMO
  • Baby food ingredients, traced from seedlings
  • Constant diets label data
  • Constancy of ingredients in formulation

No Yes Yes Yes Yes

  • Constant geographical origin of ingredients
  • Formulation remains constant in time
  • Total constancy of diets during time

Yes Yes Yes

  • Archiving of production data
  • Shelf-life of laboratory diets
  • “Easy opening’’ system (without tools) of bags of diets
  • Plastic pallets cleaned then disinfected
  • Irradiation bag by bag (not by palet)

12 years 1 to 2 years Yes Yes Yes

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RISK CONTROL

  • Pesticide risk control
  • Mycotoxin risk control
  • Doping agent risk control
  • Phytoestrogen risk control
  • Radioactivity risk control
  • Medicinal product risk control
  • Number of items of control/certified diet

+++ +++ +++ ++ +++ +++ > 162 items

RESEARCH CENTER

  • Nutrition-animal health research centre
  • Food analysis research centre

Yes Yes

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