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Scie ientifi ntific c Ani nimal l Food od & En Engin ineering eering. 2009-2010 INVIVO NSA is created with the 2003 merger of the Animal Nutrition UAR is spited in 2 businesses. 1996 and Health businesses of InViVo SAFE SAS is created as a new GUYOMARC’H NA acquires and Evialis. SAFE becomes an company, dedicated to the Lab Animal OFTEL group INVIVO NSA subsiduary. Nutrition 1956 UAR (is founded Usine d’Alimentation Rationnelle) By 2013 Raymond HUARD SAFE is again an independent 2004 company. Logo updated. SAFE business is transferred in Augy after a full refurbishing and enlargement of an Oftel plant. 2000 This New site is, since then, GUYOMARC’H NA (just dedicated to the Lab Animal Diet renamed EVIALIS) acquires production. UAR Brand of Lab animal diet business becomes SAFE. 02/02/2017 2 Confidentiel
SAF AFE th E throu ough gh the the yea years rs For over 45 years, UAR , based in the Paris region, has invested in the research sector. In 2000, UAR , conscious of the industrial challenges to be met to consolidate its (former EVIALIS group), which future, preferred to let its business to the then became: SAF AFE : Scientific Animal Food & Engineering . In 2004, SAFE opened a new industrial plant in Augy (close to Auxerre, Burgundy), fully dedicated to lab animals (unique in Europe). The accumulated experience combined with the group expertise has resulted in SAFE becoming a reference company in nutritional engineering for lab animals. 02/02/2017 3
SAF AFE th E throu ough gh the the yea years rs In 2008, SAFE plant is certified ISO 14001 In 2012, SAFE signed several partner agreements with Asian retailers In 2013, SAFE becomes an independent company. SAFE changed its shareholders, from InViVo NSA to Capital Croissance (innovation and small caps investment funds), Unigrains (Agro Food Funds), BNP-Paribas PE and SAFE’s Management. SAFE has a 55 years experience in lab animal nutrition, providing Pharmaceutical industries, CRO, Biomedical research centres, breeding facilities in over 25 countries and over 400 direct customers,.. a wide dealer’s network …. 02/02/2017 4
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Interactions Nutrients Genes & DNA Feed & Food Dialogue Nutrients : ignition or extinction vs genes & tissues WE ARE WHAT WE EAT 02/02/2017 6
In bi n biom omed edic ical al re resea earc rch, h,die iets ts, , ge gene neti tics an and en envi vironment ronment are are li link nked ed All must be totaly reliable Stable Diet Base + Stable Gene Pool + Stable Environment = Reliable Study Bases 02/02/2017 7
Sta Stable ble Die Diets ts Stable ingredients Same Origin, Same Quality, contaminant presence mastered. + Fixed formula The product you buy today will be the same tomorrow + Stable process Guaranting you that we do what we’ve said A stable and safe diet base all = along your studies 02/02/2017 8
Con onta taminants minants com ommu munly nly pre rese sent nt in in a nor a norma mal l fee feed Pesticides Radioactive components Heavy Metals Phyto- oestrogens Micotoxins Drugs Bacteria, Fungus e Vírus From process ( acrylamide,neoformed,.. ) Additives in Plant 02/02/2017 9
Authorized level of Impact on your cross contamination research studies Cross Contamination for non target animal feed (via lab diet) species (i.e lab diet) Warning/Danger With other species diets No Limit With diets containing 1 % Warning/Danger Antibiotic agent With diets containing ionophore coccidiostat 3 % Warning/Danger agent 02/02/2017 10
Commitment n ° 1 Augy industrial site entirely dedicated to the lab activity Commitment n ° 2 No use of animal nutrition additives: binders, preservatives, drugs, coccidiostats, flavorings, colorings, anti oxidants... Commitment n ° 3 Food industrial standard (no farm standard) High quality raw materials 02/02/2017 11
Concerning diets, the important thing is not what you see (type of diets, colour..), but what you don't see ! What "you don't see" is, for example, the digestibility of each ingredient in the recipe, nutritional balance, undesirable substances (mycotoxins, pollutants, doping agents such as morphine, phytoestrogens, drug type products, radioactivity, etc.). Health and veterinary risks must naturally be added to these. 02/02/2017 12
What Wh at c cho hoic ice fo e for the r the ing ingred edie ients nts used i use d in t n the he die diet? t? SAFE does not use straw cereals for farm animals but only cereals used for Baby Food . MYCOTOXINS PESTICIDES HEAVY METALS 02/02/2017 13
The industry also applies economical optimisation of diet formulae : the most expensive ingredients are replaced according to price changes with cheaper ingredients, without changing the values shown on your label (proteins, glucides, energy, etc.) or specifically informing the customer. At SAFE, this practice is completely prohibited. It would completely change your diets (difference in digestibility, appetizing factors, balance) and create a major bias in your studies which would no longer be comparable over time. SAFE diets are made with the same fixed formulas, from the same source (Augy plant) and the same ingredients. 02/02/2017 14
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In order to secure your experiments, SAFE maintain a process control that grant of traceability and consistency of our products Traceability Consistency Cross contaminations 02/02/2017 16
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SAFE’s Organization chart 02/02/2017 19
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SAFE FE Rodent Rodents die s diets ts ran ange ge Breeding Maintenance Vegetal Breeding Vegetal Maintenance 02/02/2017 21
SAFE FE Rodent Rodents die s diets ts ran ange ge Unique Aging Transgenics Unique Vegetal 02/02/2017 22
SAF AFE Die E Diets ran ange ge Minipigs & Rabbits Guinea Pigs Fowls 02/02/2017 23
SAFE AFE Di Diet ets r s ran ange ge Dogs Primates Cats & Zebra 02/02/2017 24
Diets Die ts f for or a all ll La Labo borat ator ory Anim y Animal als Irradiated >10/25/40 kGy 127 110 112 A03 A04 105 Autoclavable D03 D04 D113 Double Bag F86 114 106 D30 D40 D131 Vacuum Packed CAVIAR 150 A30 A40 125 326 1kg - 5kg - 10kg A05 D05 Certified-Control 2 mm R01T-10 R03T25 107 307 115 3 mm 02/02/2017 25
Pap aper erBa Bags gs Certified Diet Irradiated Diet Standard Diet Autoclavable Diet Double Paper Bag Double paper Bag Paper Bag Paper Bag 02/02/2017 26
Ea Easy syOp Open en Pap aper erBa Bags gs Easy Open Paper Bag 02/02/2017 27
Do Double uble pa pape perba bag Double Paper Bag 02/02/2017 28
SP P SP Pac acka kagin ging Easy open Paper Bag In Plastic Pouch 02/02/2017 29
Vac acuume uumed P d Pac acka kagin ging Easy Vacuum packaging Control 2x5kg Box Boxes Pallet 1x10kg Box 10x1kg Box Beddings packaging 02/02/2017 30
The Shelf-life dates for SAFE diets are : • 1 year for diets packed in bags • 2 years for vacuum-packed diets All SAFE diet packaging is identified by various traceability items: product name, production batch, time and best before date. The label also gives composition details in 6 languages: a list of ingredients in decreasing order, nutritional guarantees and production site accreditation number. 02/02/2017 31
Ma Maste stered ed I Irr rrad adia iatio tion Proc n Process 02/02/2017 32
Con ontroled troled / / Cer ertif tifie ied d Di Diet ets Certified Diets – 162 Analitical controls 02/02/2017 33
Con ontrole troled / C d / Cert rtif ifie ied d D Die iets ts 02/02/2017 34
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SAF AFE E i is : s : - Over 35.000 analysis performed per year, - Over 700 different criteria monitored, - 500 criteria on final products - 200 criteria on ingredients - An average of 140 analysis per batch, 02/02/2017 36
Nu Nutr trit ition ional al Con onst stancy ancy 5 Years Variation Analytical 5 Years 5 Years GV SOLAS EU Regulations Standard Coefficient Uncertaincy Samples* average* limits** Limits*** (+/- or %) deviation* (%) A03 Proteins 10 21.50 % 0,43 2 +/- 0.6 [19.5 ;24.5]% [18.81 ;24.19]% A03 Lipids 10 5.15% 0,24 4.7 +/-1 [4.35 ;6.35]% [4.15 ;7.15]% A03 Potassium 10% [7295 ;10513]ppm [6582 ;12582]ppm 10 8582ppm 523 6.1 35 15.90% 0,43 2.7 +/-0.6 [14.31 ;18.29]% [14.1 ;18.1]% A04 Proteins 34 3.06% 0,27 8.8 +/-1 [2.26 ;4.26]% [2.06 ;5.06]% A04 Lipides 33 6172 ppm 404 6.5 10% [5172 ;7672]ppm [4172 ;10172]ppm A04 Potassium * Sources SAFE **threshold calculated in accordance with GV-SOLAS, Guidelines for the Quality - Assured Production of Laboratory Animal Diets, EN A-06-2002 ***threshold calculated in accordance with RÈGLEMENT (CE) N o 767/2009 DU PARLEMENT EUROPÉEN ET DU CONSEIL du 13 juillet 2009 02/02/2017 37
Cust Custom om Die Diets ts 02/02/2017 38
Ge Gel Di l Diet ets Ra s Range nge New Gel dietBreeding Gel dietTransport Gel dietHigh fat Gel diet125C (dog) Gel dietEnergy Gel dietWater 02/02/2017 39
Be Beddin ddings gs 02/02/2017 40
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