What can a patients DNA tell health care providers Dr. Catalina - - PowerPoint PPT Presentation
What can a patients DNA tell health care providers Dr. Catalina Lopez-Correa CSO & VP Sector Development at Genome British Columbia Presidents Speakers Series Alberta Health Services (AHS) November 21st, 2016 Why Genomics? What
President’s Speakers Series Alberta Health Services (AHS) November 21st, 2016
“What physics was to the 20th century, biology will be to the 21st”
The Economist, Jun. 2007
Sanger Sequencing Next Generation Sequencing MinION Sequencing
McKinsey Global Institute May 2013: Report on Disruptive Technologies that will transform life, business and the global economy
Network Nodes
projects/initiatives funded across all life science sectors
per project
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Cumulative investment in 145 projects • 53 Active Total $352.5M: GBC $69.3M with Co-investment $283.2M
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Prevention Prognosis Treatment Diagnosis
First Nations Biobank RapidOMICS Genomics for pharmacists Biomarkers for COPD Management Prenatal Screening
Researchers: Francois Rousseau, Sylvie Langlois Safer prenatal screening solution (each year 10,000 amniocentesis cause the loss of 70 healthy fetuses). NIPT is revolutionizing prenatal care. New genomic technologies allow the detection fetal genetic abnormalities in maternal blood. Equip decision makers, pregnant women and their partner to make informed choices pertaining to prenatal genetic screening and diagnosis. High demand from the public for test coverage of NIPT – health care decision-makers will use project results to decide on coverage policies.
Researchers: Jan Christilaw, Jan Friedman, Alison Elliot and Horacio Osiovich
Approximately 50% of all emergency department visits each year are due to adverse reactions to medications in adults aged 50 and over Across BC, 33 community pharmacies have taken part in North America’s first project to implement pharmacogenomics Extract DNA from Saliva, sequence DNA and prescribe the right drug to the right patient at the right time and right dose
high risk for Chronic Obstructive Pulmonary Disease (COPD).
refining selected markers.
patients with fewer attacks and reduced hospitalization and emergency visits.
The project is led by Dr. Don Sin, St. Paul’s Hospital, University of British Columbia
In Canada over 70,000 people are infected with HIV and nearly $1 billion is spent on HIV drug cocktail therapies each year The BC Centre for Excellence is HIV/AIDS is leading the world to reduce HIV/AIDS global burden by 90 % in 2030 Genome BC is supporting the BCCfE in developing an HIV drug-resistance test, real-time drug resistance surveillance and better methods for personalizing treatment of HIV based on each patient’s unique DNA
This BC Cancer Agency project looks at the specific mutations that cause cancer. 350 patients have received personalized treatment, based on their DNA representing 50 different cancer types. The next phase: More patients, more cancers Doctors can then customize treatment
increase efficacy and reduce overall cost
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Centre for Clinical Genomics
“Test” e.g. Hereditary cancer panel Oncopanel Myeloid Panel
Ethics Privacy Economic evaluation
Populations (BC and beyond)
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The project will sequence 100,000 genomes from around 70,000 people. Participants are NHS patients with a rare disease, plus their families, and patients with cancer. The aim is to create a new genomic medicine service for the NHS – transforming the way people are cared for
This new plan will mean we are the first country in the world to use DNA codes in the mainstream of the health service. If we get this right, we could transform how we diagnose and treat our most complex diseases not only here but across the world, while enabling our best scientists to discover the next wonder drug or breakthrough technology Primer Minster David Cameron December 10, 2012
Genomics core facility Cancer Research UK Cambridge Institute
The CEO of an Icelandic gene- hunting company says he is able to identify everyone from that country who has a deadly cancer risk, but has been unable to warn people of the danger because of ethics rules governing DNA research
MIT Technology Review, 2015
Her Highness Sheikha Moza bint Nasser announced the Qatar Genome Project at the World Innovation Summit on Health (WISH) in Doha in December 2013
Data Overload – Informatics Big Data
Source: PhRMA - 2013 Biopharmaceutical Research Industry Profile
Source : « Time for one-person trials », Nature | Comment, 29 April 2015, http://www.nature.com/news/personalized- medicine-time-for-one-person-trials-1.17411
MITSloan Management, March 2008
New Yorker
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1. Scientific understanding and technical capabilities 2. Alignment and prioritization 3. Health information technology tools and infrastructure 4. Clinical and laboratory infrastructure and capabilities 5. Regulatory guidelines 6. Harmonized ethical consent 7. Privacy / anti-discrimination policies and legislation 8. Reimbursement guidelines 9. Healthcare professional capacity, awareness, training and adoption
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Capabilities / Resources Patient Adoption Provider Adoption Aggregating, Integrating and Sharing Data