University of California, Los Angeles Connectomics via the LONI - - PowerPoint PPT Presentation

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University of California, Los Angeles Connectomics via the LONI - - PowerPoint PPT Presentation

Aug 16, 2023 236 likes •391 views

Andrei Irimia, Ph.D. Laboratory of Neuro Imaging University of California, Los Angeles Connectomics via the LONI Pipeline connectogram automatic automatic parcellation segmentation DTI connectivity tractography matrix calculation

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Andrei Irimia, Ph.D. Laboratory of Neuro Imaging University of California, Los Angeles

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Connectomics via the LONI Pipeline

automatic segmentation DTI tractography automatic parcellation connectivity matrix calculation connectogram

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Connectogram interpretation

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FRONTAL

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FRONTAL INSULAR

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FRONTAL INSULAR LIMBIC

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FRONTAL INSULAR LIMBIC TEMPORAL

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FRONTAL INSULAR LIMBIC TEMPORAL PARIETAL

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FRONTAL INSULAR LIMBIC TEMPORAL PARIETAL OCCIPITAL

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Population-level connectograms

SUBJECT AVERAGING POPULATION (N=110)

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Comparing populations

HEALTHY DISEASED SIGNIFICANT DIFFERENCES vs

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Pipeline workflow

 integrated

with FreeSurfer automatic segmentation(also available through the Pipeline)

 LONI custom software uses Circos software to

generate the connectogram

 the output is the connectogram image

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References

 Irimia et al. (2012) Frontiers in Neurology, vol 3, article 10  Irimia et al. (2012) NeuroImage, vol. 60, pp. 1340-1351