The 16 th U.S.-Korea Forum on Nanotechnology nanshulu@utexas.edu - - PowerPoint PPT Presentation

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The 16 th U.S.-Korea Forum on Nanotechnology nanshulu@utexas.edu Bioelectronics Closing the Loop for Internet of Health (IoH) Data Analytics Medical diagnosis Signal Processing Prof. Dae-Hyeong Kim Seoul National Univ. Biomarker


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nanshulu@utexas.edu The 16th U.S.-Korea Forum on Nanotechnology

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Bioelectronics – Closing the Loop for Internet of Health (IoH)

Choi, Kim*, et al., Adv. Mater. 28, 4203 (2016).

Biomarker Sensing Medical diagnosis Signal Processing Data Analytics Mobile/Home Treatment

  • Prof. Dae-Hyeong Kim

Seoul National Univ.

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HUMAN-ROBOT INTERFACE MOBILE HEALTH & PERSONALIZED MEDICINE PROSTHESIS BRAIN-COMPUTER INTERFACE REHABILITATION

Example Applications of Wearable Electronics

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ESi = 130 GPa, efrac = 1% ESkin = 130 kPa, eouch = 20%

Credit: Intel Credit: ICTGraphicsLab @ USC

Silicon vs. Skin – A Mechanical Challenge

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Freeform Manufacture

  • Adv. Mater. 27, 6423-6430 (2015)

EML 2, 37-45 (2015) ACS Nano 11, 7634–7641 (2017)

  • Adv. Mater. Tech. 1800600 (2019)
  • Adv. Mater. Tech. 1900117 (2019)

Bio-Electronics Interface

JMR 30, 2702-2712 (2015)

  • Adv. Healthc. Mater. 5, 80-87 (2015)

JAM 83, 041007 (2016) Soft Robotics 3, 99-100 (2016)

  • Adv. Funct. Mater. 26, 3207-3217 (2016)

JAM 84, 111003 (2017) EML 15, 130 (2017)

  • J. Roy. Soc. Interface 14, 20170377 (2017)

Soft Matter 14, 8509 (2018) EML 30, 100496 (2019)

E-Tattoo

Skin

Soft Bioelectronics

Nature Nanotech. 9, 397–404 (2014)

  • Adv. Mater. 27, 6423-6430 (2015)

ACS Nano 9, 5937-5946 (2015) Nature Nanotech. 11, 566-572 (2016)

  • Sci. Transl. Med. 8, 86 (2016)

ACS Nano 11, 7634–7641 (2017) Nature Comm. 8,1664 (2017) npj Flexible Electronics 2, 6 (2018) Sensors 18, 1269 (2018) Micromachines 9, 170 (2018)

  • Adv. Funct. Mater. 1808247 (2019)
  • Adv. Mater. Tech. 1900117 (2019)
  • Adv. Sci. 1900290 (2019)

NPG Asia Materials 11, 43 (2019)

Lu Research Group

2D Materials & Devices

  • Adv. Mater. Interface 2, 1500176 (2015)

Nano Lett. 15, 1883–1890 (2015) Nature Nanotech. 11, 566-572 (2016) EML 13, 42-77 (2017) ACS Nano 11, 7634–7641 (2017) Nano Lett. 17, 5464 (2017) npj 2D Materials and Applications 2, 19 (2018) PNAS 115, 7884 (2018) PRL 121, 266101 (2018) Nature 567, 71 (2019) 2D Materials, accepted (2019) JMPS, revision submitted (2019)

Mechanics of Flexible and Stretchable Structures

Sensors 13, 8577-8594 (2013) IJSS 51, 4026-4037 (2014) IJF 190, 99 (2014)

  • Nat. Photonics 8, 643–649 (2014)

ACS Nano 8, 12265–12271 (2014) EML 2, 37-45 (2015)

  • Curr. Opin. Solid St. M. 19, 149-159 (2015)

IJSS 87, 48-60 (2016) Smart Mater. Struct. 25, 035037 (2016) JAM 84, 021004 (2017) Light 7, e17138 (2018) JAM 86, 051010 (2019)

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emax

2%

Serpentine Ribbons – 2D Springs

Stretchability and compliance can be achieved by serpentine structures of ANY material. eapp = 114%

Widlund, Yang, Hsu, Lu*, IJSS 51, 4026 (2014). Yang, Lu*, et al, IJF 190, 99 (2014). Yang, Lu*, et al, EML 2, 37 (2015). Yang, Qiao, Lu*, JAM 84, 021004 (2016). Liu, Ha, Lu*, JAM 86, 051010 (2019)

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Kim†, Lu†, Ma† (†equal contribution), Rogers*, et al., Science 333, 838, (2011).

Ultrathin, ultrasoft, noninvasive, stretchable and multifunctional

Strain (%) 5 10 15 20 25 30 Stress (kPa) 30 60 90 skin: 160 kPa y: 150 kPa x: 130 kPa FEM x FEM y

Ecoflex 0.5mm EP sensor

x y

Au Ecoflex PI 30µm 0.5µm

Neck Wrist

Time (sec) 1 2 3 Amplitude (V)

  • 800
  • 400

400 

  • 30

30 60 Time (sec) 1 2 3 

  • 800
  • 400

400 Amplitude (V)

  • 30

30 60 Time (sec) 1 2 3 Amplitude (V)

  • 800
  • 400

400 Amplitude (V)

  • 20

20 40 60

up down left

Time (sec) 1 2 3 

  • 800
  • 400

400 Amplitude (V)

  • 30

30 60

right up right left down

Epidermal Electronics (E-Tattoos)

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8 Fully-Conformal Non-Conformal Partially conformal

Skin

Conventional E-Tattoo

Skin Skin

Jeong, Rogers* et. al., Adv. Mater. 25, 6839 (2013).

Conformable contact ensures

  • Low interface impedance  higher signal to noise ratio
  • No slippage  less motion artifacts, more accurate

measurement of skin deformation

  • Better heat or mass transfer across the skin-tattoo interface

𝝁 = 𝟑𝟔𝟏 𝛎𝐧 𝒊𝟏 = 𝟔𝟏 𝛎𝐧 ഥ 𝑭𝒕 = ഥ 𝑭𝒏= 𝟘𝟑 𝐥𝐐𝐛 𝜹 = 𝟔𝟏 𝐧𝐊/𝐧𝟑

Conformability

𝒖 = 𝟔 𝛎𝐧 𝒖 = 𝟒𝟕 𝛎𝐧 𝒖 = 𝟐𝟏𝟏 𝛎𝐧

𝜽 𝒖 (𝛎𝐧)

Wang, Lu*, JAM 83, 041007 (2016).

Ecoflex on skin

Ultra-Soft & Ultra-Thin  Ultimate Conformability

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Electronically functional Atomically thin (nm) Optically transparent Mechanically robust (cuttable) Chemically inert Potentially low cost

World’s Thinnest Materials – 2D Materials

Jang, Lu*, et al., npj 2D Materials and Applications (invited review), in preparation (2019).

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Wet transfer Dry patterning

Ameri, Akinwande*, Lu*, et al., ACS Nano 11, 7634 (2017).

  • Prof. Deji Akinwande

UT-Austin ECE

Cut-and-Paste Manufacture of Graphene E-Tattoo Sensors (GETS)

  • Dr. Shideh K. Ameri

UT-Austin ECE (Queen’s University, Canada)

ECCS-1541684

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GETS Characterization

GETS

Serpentine

Ameri, Akinwande*, Lu*, et al., ACS Nano 11, 7634 (2017).

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Stretchability of Graphene/PMMA

2 4 6 8 10 12 14 16 18 20 10 20 30 40 50 60 70

R/R0 Applied Strain (%)

100 nm Au on 300-nm PMMA Monolayer graphene

  • n 300-nm PMMA

Straight ribbons

Jang, Lu*, et al., 2D Materials, accepted (2019).

Double-sided tape (DST) Tegaderm Au/PET Connector

Cross-Section

DST Tegaderm PMMA Au PET Gr

ɛ

Stage I

(0-0.9%)

Stage II

(0.9-2.5%)

Stage III

(2.5-8%)

Stage IV

(8%-Break)

GB

Micro- crack (Graphene)

ɛ

Macro- crack (PMMA)

ɛ ɛ

Defect

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500-nm thick

Ameri, Akinwande*, Lu*, et al., ACS Nano 11, 7634 (2017).

GETS Are Fully Conformable to the Skin

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GETS Are as Deformable as Skin

Ameri, Akinwande*, Lu*, et al., ACS Nano 11, 7634 (2017).

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Multifunctional GETS

Ameri, Akinwande*, Lu*, et al., ACS Nano 11, 7634 (2017).

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Right (-) Ground Left (+) Up (+) Down (-) Right-Left Channel Up-Down Channel

Normal Sour-face Laugh Frown

Transparent GETS for Electrooculogram (EOG)

Ameri, Akinwande*, Lu*, et al., npj 2D Materials and Applications 2, 19 (2018).

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Imperceptible Human Robot Interface (HRI) by GETS

Ameri, Akinwande*, Lu*, et al., npj 2D Materials and Applications 2, 19 (2018).

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18 Lee, Lu, Kim*, et al., Nat. Nanotech. 11, 566-572 (2016).

  • Prof. Dae-Hyeong Kim

Seoul National Univ.

Graphene-Based E-Tattoo for Diabetics

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Going Wireless – Near Field vs. Far Field Technology

Near Field (Induction) Far Field (Radiation)

Advantage Disadvantage Advantage Disadvantage

  • Less power

consumption

  • Passive mode

without battery

  • Data transfer rate

: 424 kpbs

  • Operating range

: ~10 cm

  • Data transfer rate

: 3 Mbps

  • Operating range

: ~10 m

  • Battery powered

DOMINANT TERMS IN THE REGION (Power density attenuation)

𝒔 : distance

1 𝑠6 1 𝑠2

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“Cut-Solder-Paste” Method for Integrating ICs on E-Tattoos

Cu foil Thermal Release Tape Water Soluble Tape Kapton Tape Water Tegaderm

a b d h g e c Soldering f Water Pasting Cutting

Jeong, Lu*, et al., Adv. Mater. Tech. 1900117 (2019).

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Robustness of Wireless E-Tattoos

Jeong, Lu*, et al., Adv. Mater. Tech. 1900117 (2019).

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Assembly and Disassembly up to 20 times

A B C D Peeling off Peeled off Laminating Laminated

20 repetitions

E

NFC+Temp // SpO2

SpO2 layers

Jeong, Lu*, et al., Adv. Mater. Tech. 1900117 (2019).

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Acknowledgement