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Snail Model System Intro to snails as a model system in - - PowerPoint PPT Presentation
Snail Model System Intro to snails as a model system in - - PowerPoint PPT Presentation
Snail Model System Intro to snails as a model system in neurobiology Our lab snail Pond snail brains Identified neurons in pond snail brains dorsal ventral Snail Buccal Ganglia Buccal ganglia neurons Smail Week 1. Firing
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Pond snail brains
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ventral dorsal
Identified neurons in pond snail brains
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Snail Buccal Ganglia
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Buccal ganglia neurons
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Smail Week 1. Firing properties of snail neurons
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Responses to current injection
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Firing Accomondation
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Post-inhibitory rebound
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Burster neurons
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Snail week 2. Ionic mechanisms of excitability
Reduced Na Reduced Ca
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K+ Channel block with TEA
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K+ Channel block with TEA/Cs
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TEA/CS block progressing over time (5 minutes)
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K+ Channel block with barium
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Excitability mechanisms: Voltage Clamp
Describing the ionic conductances underlying the AP
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Voltage clamp technique to examine ionic currents
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Problems analyzing conductances underlying AP
- 1. ICm obscured IRm
- 2. Conductances changed during AP
Current across membrane Im = I Rm + ICm
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Ohm’s law for V-Clamp
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Ionic driving forces at rest
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Ionic driving forces at rest
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Current across membrane with hyperpolarizations Im = I Rm + ICm
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Current across membrane with weak depolarizations
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Current across membrane with strong depolarizations
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