Shipping Biolog ic a l Substa nc e s (+/ - Dry Ic e ) Cancer Trials - - PowerPoint PPT Presentation

www.cancertrials.ie www.cancertrials.ie

Shipping Biolog ic a l Substa nc e s (+/ - Dry Ic e )

Cancer Trials Ireland Training Course Biological Substance/Dry Ice_V2.0_27‐Mar‐18

www.cancertrials.ie www.cancertrials.ie

Obje c tive

• To provide training on requirements for shipping

Biological Substances and responsibilities of site staff to ensure compliance with regulations and promote awareness of personal safety regarding handling of Biological Substances and shipping materials (dry ice)

Cancer Trials Ireland Training Course Biological Substance/Dry Ice_V2.0_27‐Mar‐18

www.cancertrials.ie www.cancertrials.ie

Conte nt

• Substance Category
• Shipping Regulations
• Hazardous Materials
• Dry Ice
• Exempt Human & Animal Specimens
• Biological Substances, Category B
• Summary

Cancer Trials Ireland Training Course Biological Substance/Dry Ice_V2.0_27‐Mar‐18

www.cancertrials.ie www.cancertrials.ie

Substa nc e Ca te g ory

This course covers the transport of Category B, Exempt Human & Animal Specimens, Dry Ice. This course dose not cover the transport of Infectious Substances, Affecting Humans, Category A (cultured

• r amplified stocks of human pathogens OR

genetically modified organisms or microorganisms meeting the definition of an Infectious Substance, Category A material

Cancer Trials Ireland Training Course Biological Substance/Dry Ice_V2.0_27‐Mar‐18

www.cancertrials.ie www.cancertrials.ie

Shipping Re g ula tions

A variety of national and international agencies regulate the transport, exporting, and importing of research materials. These agencies include the:

• International Air Transport Association (IATA)

Each country and/or hazardous material carrier/courier can have their own regulations in addition to the national and international requirements

Cancer Trials Ireland Training Course Biological Substance/Dry Ice_V2.0_27‐Mar‐18

www.cancertrials.ie www.cancertrials.ie

Purpose of Shipping Re g ula tions

Ensure safe shipment of research materials through:

• Training people involved in any aspect of shipping
• Properly classifying research materials
• Packaging research materials to prevent release

during transport

• Identifying research materials on the package and

shipping papers Only training personnel may be involved in research material shipping or transport

Cancer Trials Ireland Training Course Biological Substance/Dry Ice_V2.0_27‐Mar‐18

www.cancertrials.ie www.cancertrials.ie

F

• llowing Shipping Re g ula tions

The shipper is responsible for complying with all applicable shipping regulations including permits and export licences.

• Instructions/Guidance should be sought when

necessary.

Cancer Trials Ireland Training Course Biological Substance/Dry Ice_V2.0_27‐Mar‐18

www.cancertrials.ie www.cancertrials.ie

F

• llowing Shipping Re g ula tions

Failure to follow shipping regulations may result in the following:

• Package delays during transport
• Mishandling by the courier
• Potential for inadvertent release of the contents
• Criminal/civil penalties

Complying with shipping regulations protects the material being shipped, those individuals handling the Package , and controls the potential for negative impacts on the environment.

Cancer Trials Ireland Training Course Biological Substance/Dry Ice_V2.0_27‐Mar‐18

www.cancertrials.ie www.cancertrials.ie

De finition of Ha za rdous Ma te ria l

A Hazardous Material is defined as a substance or material, that when transported is capable of posing a risk to health, safety, or property. Hazardous Materials include biological, chemical and radioactive materials.

Cancer Trials Ireland Training Course Biological Substance/Dry Ice_V2.0_27‐Mar‐18

www.cancertrials.ie www.cancertrials.ie

Ha za rdous Ma te ria l T ra ining

Staff who perform any of the following with Hazardous Materials must be trained on a regular basis:

• Package
• Prepare Shipping paperwork
• Handle
• Transport
• Receive

Cancer Trials Ireland Training Course Biological Substance/Dry Ice_V2.0_27‐Mar‐18

www.cancertrials.ie www.cancertrials.ie

Ha za rdous Ma te ria l Cla sse s

Cancer Trials Ireland Training Course Biological Substance/Dry Ice_V2.0_27‐Mar‐18

www.cancertrials.ie www.cancertrials.ie

Cla ssifying Ha za rdous Ma te ria ls

Each Hazardous Material listed in the IATA Hazardous Materials table is assigned a UN (United Nations) number. The UN number allows emergency responders to act appropriately in the event of an incident.

Cancer Trials Ireland Training Course Biological Substance/Dry Ice_V2.0_27‐Mar‐18

www.cancertrials.ie www.cancertrials.ie

Cla ssifying Ha za rdous Ma te ria ls

Cancer Trials Ireland Training Course Biological Substance/Dry Ice_V2.0_27‐Mar‐18

www.cancertrials.ie www.cancertrials.ie

Pa c ka g ing

Cancer Trials Ireland Training Course Biological Substance/Dry Ice_V2.0_27‐Mar‐18

www.cancertrials.ie www.cancertrials.ie

Dry Ic e

Dry ice is classified by IATA as a miscellaneous hazard, class 9 during transportation for three reasons:

Cancer Trials Ireland Training Course Biological Substance/Dry Ice_V2.0_27‐Mar‐18

www.cancertrials.ie www.cancertrials.ie

Ha ndling Dry Ic e

• Dry ice must be stored in a well-ventilated location

well-ventilated location. NEVER store dry ice in a cold room, warm room, tightly sealed device, closet, plastic/glass container, or other enclosed space unless adequate supply ventilation is provided, as the sublimation of dry ice to CO2 gas will cause an airtight container to expand or possibly explode explode. In small amounts, CO2 is harmless, but in larger quantities it can lead to shortness shortness of breath reath or even

• asphyxiation. It is important to always use dry ice in a

well-ventilated area

http://www.uvm.edu/safety/lab/DryIce http://polarice.ie/about‐dry‐ice/health‐safety/ Cancer Trials Ireland Training Course Biological Substance/Dry Ice_V2.0_27‐Mar‐18

www.cancertrials.ie www.cancertrials.ie

Ha ndling Dry Ic e

• NEVER handle dry ice with your bare hands. Dry ice

temperature is –78.5ºC. Always wear thermal gloves Always wear thermal gloves to reduce risk of thermal burns to the skin.

• Wear long pants, sleeves and closed toe shoes

long pants, sleeves and closed toe shoes to cover any areas of skin that might be exposed to dry ice.

• Wear safety glasses when breaking a big block of dry

ice.

• Never place your head near dry ice vessel.

If you working with or near dry ice and suddenly find you are having difficulty breathing or are out of breath,

• pen any nearby windows and vacate the area for at

least 10 to 15 minutes.

http://www.uvm.edu/safety/lab/DryIce http://polarice.ie/about‐dry‐ice/health‐safety/ Cancer Trials Ireland Training Course Biological Substance/Dry Ice_V2.0_27‐Mar‐18 http://www.ecu.edu/cs‐admin/oehs/ih/Dry‐Ice.cfm

www.cancertrials.ie www.cancertrials.ie

Ha ndling Dry Ic e

Dispose of unneeded dry ice by:

• Letting the unused portion sublimate in a

Letting the unused portion sublimate in a well- well- ventilated area clear of people e.g. ventilated area clear of people e.g. fume hood. fume hood.

• NEVER dispose of dry ice in a sink, other device or

trash.

• NEVER leave unneeded dry ice in hallways or other

public areas.

• Do not place dry ice on a solid surface countertop as

the extreme cold will cause damage. Never transport dry ice in your personal vehicle.

http://www.uvm.edu/safety/lab/DryIce http://polarice.ie/about‐dry‐ice/health‐safety/ Cancer Trials Ireland Training Course Biological Substance/Dry Ice_V2.0_27‐Mar‐18 http://www.ecu.edu/cs‐admin/oehs/ih/Dry‐Ice.cfm

www.cancertrials.ie www.cancertrials.ie

Pa c ka g ing Dry Ic e

Cancer Trials Ireland Training Course Biological Substance/Dry Ice_V2.0_27‐Mar‐18

www.cancertrials.ie www.cancertrials.ie

Pa c ka g ing Dry Ic e

Cancer Trials Ireland Training Course Biological Substance/Dry Ice_V2.0_27‐Mar‐18

Secure your samples in such a way that when dry ice sublimates, they will not move freely inside of the insulated box. This can be accomplished by wedging your samples in place with cardboard or Styrofoam. Fragile containers such as glass tubes or vials must be wrapped with cushioning material. Dry Ice Shipments should not be placed in just a

• Styrofoam. The Styrofoam must be placed into a

cardboard box.

www.cancertrials.ie www.cancertrials.ie

L a be lling for Dry Ic e

Cancer Trials Ireland Training Course Biological Substance/Dry Ice_V2.0_27‐Mar‐18

www.cancertrials.ie www.cancertrials.ie

L a be lling for Dry Ic e

Cancer Trials Ireland Training Course Biological Substance/Dry Ice_V2.0_27‐Mar‐18

www.cancertrials.ie www.cancertrials.ie

L a be lling for Dry Ic e

Cancer Trials Ireland Training Course Biological Substance/Dry Ice_V2.0_27‐Mar‐18

www.cancertrials.ie www.cancertrials.ie

E xe mpt Huma n & Anima l Spe c ime ns

Cancer Trials Ireland Training Course Biological Substance/Dry Ice_V2.0_27‐Mar‐18

www.cancertrials.ie www.cancertrials.ie

Pa c ka g ing : E xe mpt Huma n & Anima l Spe c ime ns

Cancer Trials Ireland Training Course Biological Substance/Dry Ice_V2.0_27‐Mar‐18

www.cancertrials.ie www.cancertrials.ie

Pa c ka g ing : E xe mpt Huma n & Anima l Spe c ime ns

Cancer Trials Ireland Training Course Biological Substance/Dry Ice_V2.0_27‐Mar‐18

www.cancertrials.ie www.cancertrials.ie

L a be lling : E xe mpt Huma n & Anima l Spe c ime ns

Cancer Trials Ireland Training Course Biological Substance/Dry Ice_V2.0_27‐Mar‐18

www.cancertrials.ie www.cancertrials.ie

L a be lling : E xe mpt Huma n Spe c ime ns

Cancer Trials Ireland Training Course Biological Substance/Dry Ice_V2.0_27‐Mar‐18

www.cancertrials.ie www.cancertrials.ie

L a be lling : E xe mpt Huma n Spe c ime ns on Dry Ic e

Cancer Trials Ireland Training Course Biological Substance/Dry Ice_V2.0_27‐Mar‐18

www.cancertrials.ie www.cancertrials.ie

Biolog ic a l Substa nc e s, Ca te g ory B

Cancer Trials Ireland Training Course Biological Substance/Dry Ice_V2.0_27‐Mar‐18

www.cancertrials.ie www.cancertrials.ie

Biolog ic a l Substa nc e s, Ca te g ory B

Cancer Trials Ireland Training Course Biological Substance/Dry Ice_V2.0_27‐Mar‐18

www.cancertrials.ie www.cancertrials.ie

Biolog ic a l Substa nc e s, Ca te g ory B

Cancer Trials Ireland Training Course Biological Substance/Dry Ice_V2.0_27‐Mar‐18

www.cancertrials.ie www.cancertrials.ie

Biolog ic a l Substa nc e s, Ca te g ory B

Cancer Trials Ireland Training Course Biological Substance/Dry Ice_V2.0_27‐Mar‐18

www.cancertrials.ie www.cancertrials.ie

Pa c ka g ing : Biolog ic a l Substa nc e s, Ca te g ory B

Subject to Packaging Instruction 650

Cancer Trials Ireland Training Course Biological Substance/Dry Ice_V2.0_27‐Mar‐18

www.cancertrials.ie www.cancertrials.ie

Pa c ka g ing : Biolog ic a l Substa nc e s, Ca te g ory B

Cancer Trials Ireland Training Course Biological Substance/Dry Ice_V2.0_27‐Mar‐18

www.cancertrials.ie www.cancertrials.ie

Pa c ka g ing : Biolog ic a l Substa nc e s, Ca te g ory B

Cancer Trials Ireland Training Course Biological Substance/Dry Ice_V2.0_27‐Mar‐18

www.cancertrials.ie www.cancertrials.ie

Pa c ka g ing : Biolog ic a l Substa nc e s, Ca te g ory B

Cancer Trials Ireland Training Course Biological Substance/Dry Ice_V2.0_27‐Mar‐18

www.cancertrials.ie www.cancertrials.ie

Pa c ka g ing : Biolog ic a l Substa nc e s, Ca te g ory B

Cancer Trials Ireland Training Course Biological Substance/Dry Ice_V2.0_27‐Mar‐18

www.cancertrials.ie www.cancertrials.ie

Pa c ka g ing : Biolog ic a l Substa nc e s, Ca te g ory B

Cancer Trials Ireland Training Course Biological Substance/Dry Ice_V2.0_27‐Mar‐18

www.cancertrials.ie www.cancertrials.ie

L a be lling : Biolog ic a l Substa nc e s, Ca te g ory B

Cancer Trials Ireland Training Course Biological Substance/Dry Ice_V2.0_27‐Mar‐18

www.cancertrials.ie www.cancertrials.ie

L a be lling : Biolog ic a l Substa nc e s, Ca te g ory B

Cancer Trials Ireland Training Course Biological Substance/Dry Ice_V2.0_27‐Mar‐18

www.cancertrials.ie www.cancertrials.ie

L a be lling : Biolog ic a l Substa nc e s, Ca te g ory B

• n Dry Ic e

Cancer Trials Ireland Training Course Biological Substance/Dry Ice_V2.0_27‐Mar‐18

www.cancertrials.ie www.cancertrials.ie

Shipping Doc ume nta tion: Biolog ic a l Substa nc e s, Ca te g ory B

Cancer Trials Ireland Training Course Biological Substance/Dry Ice_V2.0_27‐Mar‐18

www.cancertrials.ie www.cancertrials.ie

Shipping Doc ume nta tion: Biolog ic a l Substa nc e s, Ca te g ory B

Cancer Trials Ireland Training Course Biological Substance/Dry Ice_V2.0_27‐Mar‐18

www.cancertrials.ie www.cancertrials.ie

Shipping Doc ume nta tion: Biolog ic a l Substa nc e s, Ca te g ory B on Dry Ic e

Cancer Trials Ireland Training Course Biological Substance/Dry Ice_V2.0_27‐Mar‐18

www.cancertrials.ie www.cancertrials.ie

Shipping Re g ula tions Summa ry

Cancer Trials Ireland Training Course Biological Substance/Dry Ice_V2.0_27‐Mar‐18

www.cancertrials.ie www.cancertrials.ie

Shipping Re g ula tions Summa ry

Cancer Trials Ireland Training Course Biological Substance/Dry Ice_V2.0_27‐Mar‐18

www.cancertrials.ie www.cancertrials.ie

Study- Spe c ific Instruc tions

• Read and train on Study-Specific Instructions/

Manual

• Comply with Study-Specific Instructions
• Use Study-Specific packaging/shipping materials if

provided

• Order Study-Specific packaging/shipping materials

in a timely manner (if provided)

• Use Study-Specific checklists if provided

Cancer Trials Ireland Training Course Biological Substance/Dry Ice_V2.0_27‐Mar‐18