Recent advances in gastrointestinal Mapping and Modelling Tim - - PowerPoint PPT Presentation

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Recent advances in gastrointestinal Mapping and Modelling Tim Angeli, PhD Auckland Bioengineering Institute University of Auckland, New Zealand Slow Waves and Gastric Contractions Previous Slow Wave Studies High-Resolution (HR) Electrical

SLIDE 1

Recent advances in gastrointestinal Mapping and Modelling

Tim Angeli, PhD

Auckland Bioengineering Institute University of Auckland, New Zealand

SLIDE 2

Slow Waves and Gastric Contractions

SLIDE 3

Previous Slow Wave Studies

SLIDE 4

High-Resolution (HR) Electrical Mapping

Du et al, Ann Biomed Eng 2009; 37:839-46 O‘Grady et al, Am J Physiol Gastrointest Liver Physiol 2010; 299:G585-92

SLIDE 5

GEMS Software Package

Yassi et al, BMC Gastroenterol 2012;12:60. Paskaranandavadivel et al, IEEE Trans Biomed Eng 2012; 59:882-89.

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Recent Mapping Cohort

1) Healthy Controls

n = 21 patients
Devoid of gastric pathology

2) Gastroparesis

n = 12 patients
Diagnosed with medically refractory gastroparesis

3) Chronic Unexplained Nausea and Vomiting (CUNV)

n = 8 patients
Diagnosed with CUNV

Angeli et al, Gastroenterology 2015; 149:56-66.e5. O‘Grady et al, Gastroenterology 2012; 143:589-98. O‘Grady et al, Am J Physiol 2010; 299:G585-92.

SLIDE 7

Healthy Control: Normal Activity

Angeli et al, Gastroenterology 2015; 149:56-66.e5. O‘Grady et al, Gastroenterology 2012; 143:589-98.

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Gastroparesis Abnormal Initiation: Unstable

O‘Grady et al, Gastroenterology 2012; 143:589-98.

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CUNV Abnormal Initiation: Stable

Angeli et al, Gastroenterology 2015; 149:56-66.e5.

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Updated Dysrhythmia Classification

Angeli et al, Gastroenterology 2015; 149:56-66.e5. O‘Grady et al, Gastroenterology 2012; 143:589-98.

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Multi-Scale Mathematical Modelling

Multiscale Mathematical Model

Du et al. WIREs Syst Biol Med 2013;5:481-93.

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Multi-Scale Mathematical Modelling

Du et al. WIREs Syst Biol Med 2013;5:481-93.

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Tissue-Level Slow Wave Propagation

Wild Type Knockout

Du et al. Biophys J 2010;98(9):1772-81.

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Organ-Level Slow Wave Propagation

Du et al. Biophys J 2010;99(9):2784-92.

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Body-Surface Slow Wave Potentials

Du et al. Biophys J 2010;99(9):2784-92.

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Dysrhythmia in Gastroparesis

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Conclusions

High-resolution mapping and multi-scale modelling have

provided improved insights into gastrointestinal regulation, function, and health.

Engineering principles can be highly valuable in improving
ur understanding of the processes and mechanisms of

digestion.

These data and methods may provide an enhanced basis

for the research and development of functionally-targeted food and nutrition.

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Horizons: Diagnostics

Endoscopic Diagnosis Bedside Tests Clinical Translation

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Horizons: Therapy

Ablation Pacing

experimental model

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Horizons: Functional Nutrition

Brit. J. Anaesth. 2000; 84(3):367-71.
Dig. Dis. Sci. 2005; 50(10):1889-97.
Am. J. Physiol. Gastrointest. Liver Physiol. 2003; 284:G481-9.

SLIDE 21

Team Funding

Prof John Windsor A/Prof Leo Cheng Dr Peng Du Dr Greg O’Grady Dr Tim Angeli Dr Niranchan Paskaranandavadivel