Prospect of CSC-targeting Therapy Kyoto Univ. Faculty of Medicine - PowerPoint PPT Presentation

Jul 01, 2023 •433 likes •570 views

Prospect of CSC-targeting Therapy Kyoto Univ. Faculty of Medicine (1) Seigi Oshima Outline 1. Cancer stem cells (CSCs) 2. Previous studies on CSC-targeting therapy 3. My suggestion on the novel therapy 4. Conclusion Whats a Cancer Stem

Prospect of CSC-targeting Therapy Kyoto Univ. Faculty of Medicine (1) Seigi Oshima
Outline 1. Cancer stem cells (CSCs) 2. Previous studies on CSC-targeting therapy 3. My suggestion on the novel therapy 4. Conclusion
What’s a Cancer Stem Cell (CSC)? CSC…. This figure is cited from http://www.childrenshospital.org/gallery/index.cfm?G=67
Normal anticancer drugs target only nCSCs …. nCSC CSC relapse
CSC-targeting Therapy 1. Differentiation therapy 2.CSC niche targeting therapy 3.Direct reprogramming
What’s direct reprogramming?
What’s Direct Reprogramming? differentiation iPS cells Cells you like Somatic cells Cells you like
Previous Studies Yamanaka factors Cancer cells iPS cells
Suggestion • If direct reprogramming can be applied to CSCs, then this method is novel cancer treatment. certain transcription factors Cancer Stem Cells Normal cells
Hurdles toward my suggestion 1. Possibility of developing cancer 2. Extraction of pure CSCs from tumors 3. Drug delivery system
The Future Prospect Victory over Discovery of • CSC Drug CSC-targeting cancer markers Screening drug

Download Presentation

Download Policy: The content available on the website is offered to you 'AS IS' for your personal information and use only. It cannot be commercialized, licensed, or distributed on other websites without prior consent from the author. To download a presentation, simply click this link. If you encounter any difficulties during the download process, it's possible that the publisher has removed the file from their server.

Recommend

Beyond the CENTRIC Trial eyo d t e C C a Integrin Targeting for Tumor Therapy

OncoRay OncoRay National Center for National Center for Radiation Research in Oncology, Dresden Beyond the CENTRIC Trial eyo d t e C C a Integrin Targeting for Tumor Therapy Sensitization Nils Cordes Cell adhesion and Survival

531 views • 31 slides

Targeting the ATR Kinase in Cancer Therapy 2017 Chabner Colloquium October 30, 2017 Lee Zou MGH

Targeting the ATR Kinase in Cancer Therapy 2017 Chabner Colloquium October 30, 2017 Lee Zou MGH Cancer Center Harvard Medical School Disclosure Consultant/advisory role: Loxo Oncology DNA Damage and Replication Stress Response Pathways

1.04k views • 81 slides

Targeting the patient with most to gain from Augmented Passive Immunotherapy with P4 Dr Ben

Targeting the patient with most to gain from Augmented Passive Immunotherapy with P4 Dr Ben Morton MBChB FRCA Clinical Research Fellow Background Severe sepsis is a major international public health problem Effective therapy limited

494 views • 10 slides

How to Find the Poor: Field Experiments on Targeting Abhijit Banerjee, MIT Why is targeting

How to Find the Poor: Field Experiments on Targeting Abhijit Banerjee, MIT Why is targeting hard? Targeting entails a different set of challenges in developing countries because governments lack reliable data on incomes Several

552 views • 40 slides

PROSPECT PEBL ESTATE PARTNERSHIP PEBLS VISION In 10 years time, the Prospect Estate

PROSPECT PEBL ESTATE PARTNERSHIP PEBLS VISION In 10 years time, the Prospect Estate will be a welcoming, safe, thriving community where individual strengths are recognised; people are actively involved and are proud to live.

624 views • 11 slides

MUSIC THERAPY MUSIC THERAPY What is music therapy? Music therapy is simply the process of using

MUSIC THERAPY MUSIC THERAPY What is music therapy? Music therapy is simply the process of using music to change a persons behaviour or provide memories to improve clarity. What is music therapy? Music can alter moods to manage

996 views • 30 slides

Improving Privacy Protection in the area of Behavioural Targeting Privacy & Innovation, Hong

Dr. Frederik Borgesius Improving Privacy Protection in the area of Behavioural Targeting Privacy & Innovation, Hong Kong 8 June 2015 Behavioural targeting: tracking Targeting Targeting Targeting Targeting Tracking Tracking Current

456 views • 24 slides

Cosmogenic Background Characterization with PROSPECT Xianyi Zhang 12/10/2019 for the PROSPECT

This work was performed under the auspices of the U.S. Department of Energy by LLNL-PRES-798598 Lawrence Livermore National Laboratory under Contract DE-AC52-07NA27344. Cosmogenic Background Characterization with PROSPECT Xianyi Zhang

452 views • 16 slides

Shockwave Therapy Also referred to as Extracorporeal Shockwave Therapy TensCare Shockwave Therapy

Shockwave Therapy Also referred to as Extracorporeal Shockwave Therapy TensCare Shockwave Therapy Unit Introduction ESWT Shockwave Therapy is a non-invasive therapy that uses acoustic waves to treat various Musculoskeletal conditions.

1.63k views • 11 slides

Cosmogenic Fast Neutron Backgrounds in the PROSPECT Reactor Antineutrino Detector Christian Nave

Cosmogenic Fast Neutron Backgrounds in the PROSPECT Reactor Antineutrino Detector Christian Nave | Drexel University, on behalf of the PROSPECT Collaboration APS April Meeting: April 19, 2020 arXiv: 1808.00097 PROSPECT: Precision Reactor

276 views • 12 slides

An overview of the difference between inflation targeting, NGDP targeting, and a Taylor Rule;

An overview of the difference between inflation targeting, NGDP targeting, and a Taylor Rule; An argument as to why NGDP targeting generally makes more sense; An argument to the effect that inflation targeting is particularly

465 views • 21 slides

Targeting Molecular Subsets in Metastatic Colorectal Cancer (dMMR, HER2, or BRAF V600E): Is it

Targeting Molecular Subsets in Metastatic Colorectal Cancer (dMMR, HER2, or BRAF V600E): Is it Time for Frontline Targeted Therapy? Benjamin A. Weinberg, M.D. Assistant Professor of Medicine Lombardi Comprehensive Cancer Center Georgetown

469 views • 26 slides

Mobile Ad Effectiveness: Hyper-Contextual Targeting with Crowdednes 2 Mobile Targeting

Mobile Ad Effectiveness: Hyper-Contextual Targeting with Crowdednes 2 Mobile Targeting Motivation Ad spending: $100B by 2018 Key: reach consumers when and where most receptive 3 eMarketer 2014 Mobile Technology Portability =

464 views • 33 slides

Pathology of neoadjuvant therapy Neoadjuvant therapy Types of neoadjuvant therapy and their

Pathology of neoadjuvant therapy Neoadjuvant therapy Types of neoadjuvant therapy and their implications Short-term versus long-term Interval issues Staging after neoadjuvant therapy ypTNM issues Lymph node

669 views • 62 slides

OFFICE OF MEDICAID POLICY AND PLANNING END OF THERAPY DATA COLLECTION DEFINITION End of therapy

OFFICE OF MEDICAID POLICY AND PLANNING END OF THERAPY DATA COLLECTION DEFINITION End of therapy date (EOT) End of therapy date means the date the therapy regimen ended for physical therapy, occupational therapy, and speech-language

789 views • 27 slides

Identifying & Reaching Your Ideal Prospect From your friends @ Heres a question for

Identifying & Reaching Your Ideal Prospect From your friends @ Heres a question for ya Whos your ideal prospect? Often, we hear answers like The C-Suite Marketing professionals Anyone who needs financial

598 views • 16 slides

. Improving the Performance of Introduction (1) Interactive TCP Applications using Service

. Improving the Performance of Introduction (1) Interactive TCP Applications using Service Differentiation Everyone has experience with bad delays Interactive apps (audioconference, telnet, W. Noureddine and F. Tobagi games) need

318 views • 6 slides

The Nuts and Bolts of ESSA: What Every Principal Should Know About the Law's Accountability The

The Nuts and Bolts of ESSA: What Every Principal Should Know About the Law's Accountability The Every Student Succeeds Act Bipartisan support for S. 1177; became Public Law No: 114-95 on December 10, 2015 USED Dear Colleague

1.05k views • 26 slides

BCD Smart Power Roadmap Trends and Challenges Giuseppe Croce NEREID WORKSHOP Smart Energy

BCD Smart Power Roadmap Trends and Challenges Giuseppe Croce NEREID WORKSHOP Smart Energy Bertinoro, October 20 th Outline 2 Introduction Major Trends in Smart Power ASICs An insight on (some) differentiating enablers

341 views • 19 slides

One More Advantage of Deep Learning: From Traditional NN . . . While in General, A Perfect

Why Traditional . . . How the Need for Fast . . . Faster Differentiation: . . . Beyond Traditional NN One More Advantage of Deep Learning: From Traditional NN . . . While in General, A Perfect Training Formulation of the . . . of a Neural

446 views • 29 slides

Pathogenesis, diagnosis and monitoring of Acute Promyelocytic Leukemia Laura Cicconi, MD

Pathogenesis, diagnosis and monitoring of Acute Promyelocytic Leukemia Laura Cicconi, MD University Tor Vergata, Rome , 7 th INTERNATIONAL SYMPOSIUM ON ACUTE PROMYELOCYTIC LEUKEMIA Rome, 24-27 September 2017 Outline Pathogenesis &

530 views • 33 slides

Innovation and value creation Alan Hippe, CFO Roche Group J.P. Morgan Healthcare Conference San

Innovation and value creation Alan Hippe, CFO Roche Group J.P. Morgan Healthcare Conference San Francisco, January 12th, 2016 This presentation contains certain forward-looking statements. These forward-looking statements may be identified by

688 views • 39 slides

Is it difficult to create Intuitive user interfaces? Straight forward to do? user

Introduction 8.10.2007 Motivation Unconventional User Interaction Design for creative use What is User Interface Engineering Technology trends User Interfaces in a Pervasive Computing World Examples LumiTouch Bed as

893 views • 10 slides

Disclosures Drug-induced Liver Disease: I have nothing to disclose. Problem Patterns Raga

5/26/2018 Disclosures Drug-induced Liver Disease: I have nothing to disclose. Problem Patterns Raga Ramachandran, MD PhD UCSF Pathology May 26, 2018 raga.ramachandran@ucsf.edu Acute liver failure Evaluating a liver biopsy for drug etiology

263 views • 12 slides