SLIDE 1
Prospect of CSC-targeting Therapy
Kyoto Univ. Faculty of Medicine (1)
Outline
- 1. Cancer stem cells (CSCs)
- 2. Previous studies on CSC-targeting
therapy
- 3. My suggestion on the novel therapy
- 4. Conclusion
Prospect of CSC-targeting Therapy Kyoto Univ. Faculty of Medicine - - PowerPoint PPT Presentation
Prospect of CSC-targeting Therapy Kyoto Univ. Faculty of Medicine - - PowerPoint PPT Presentation
Prospect of CSC-targeting Therapy Kyoto Univ. Faculty of Medicine (1) Seigi Oshima Outline 1. Cancer stem cells (CSCs) 2. Previous studies on CSC-targeting therapy 3. My suggestion on the novel therapy 4. Conclusion Whats a Cancer Stem
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SLIDE 3
What’s a Cancer Stem Cell (CSC)?
CSC….
This figure is cited from http://www.childrenshospital.org/gallery/index.cfm?G=67
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Normal anticancer drugs target
- nly nCSCs….
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nCSC CSC
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CSC-targeting Therapy
- 1. Differentiation therapy
2.CSC niche targeting therapy 3.Direct reprogramming
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What’s direct reprogramming?
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What’s Direct Reprogramming?
iPS cells Somatic cells
differentiation
Cells you like
Cells you like
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Previous Studies
Cancer cells
Yamanaka factors
iPS cells
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Suggestion
- If direct reprogramming can be
applied to CSCs, then this method is novel cancer treatment.
certain transcription factors
Normal cells Cancer Stem Cells
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Hurdles toward my suggestion
- 1. Possibility of developing cancer
- 2. Extraction of pure CSCs from
tumors
- 3. Drug delivery system
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The Future Prospect
Discovery of CSC-targeting drug
Drug Screening
- CSC
markers
Victory over cancer
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