Previous Involvement With China 1983-4 Guangzhou: project on - - PowerPoint PPT Presentation

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Feb 06, 2023 395 likes •572 views

Previous Involvement With China 1983-4 Guangzhou: project on leishmaniasis 1987- Xinjiang: set up and participated in multi- disciplinary project on hydatid disease. Developed new formulation for albendazole which is now used in clinic 1993

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Previous Involvement With China

1983-4 Guangzhou: project on leishmaniasis 1987- Xinjiang: set up and participated in multi- disciplinary project on hydatid disease. Developed new formulation for albendazole which is now used in clinic 1993 Lectured in Guilin on snake venom vaccines 2002/3 Part of two UK government delegations to China on biotechnology

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helping the biotech industry achieve its full potential Oral delivery of peptides and proteins A revolutionary new method of drug discovery Oral vaccine carriers

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Present Involvement

Set up and use facility in China to conduct large-animal preclinical studies for pharmaceutical development

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Pig Model for Studying Intestinal Absorption of Peptides Pig Model for Studying Intestinal Absorption of Peptides

Single capsule administered to pig (40-60 kg) via indwelling stoma in jejunum. Blood samples taken at intervals thereafter.

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Fall in plasma glucose (mmol/L)

1 2 3 4 1 2 3 4

Time in hours Effect of unformulated insulin (200iu) on plasma glucose levels Effect on plasma glucose levels of insulin (200iu) in oral delivery vehicle (capsule)

Delivery of Insulin via the Oral Route Delivery of Insulin via the Oral Route

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Current Status

Work done in China has laid basis for formulations such as Proxima’s oral insulin to proceed to phase II human clinical trials, and is ready to go to phase III Advantages to small biotech: Less bureaucracy Less cost More flexibility