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Prama/Cosmetic OMWW Polyphenols - Health Anti-oxidant Skin - - PowerPoint PPT Presentation
Prama/Cosmetic OMWW Polyphenols - Health Anti-oxidant Skin - - PowerPoint PPT Presentation
Pharma/Food Industries Requirements from Isolated Phenols BGU, Prof. Z. Wiesman MARS UF-NF System Irrigation OMWW Hydroxytyrosol Food Industry Prama/Cosmetic OMWW Polyphenols - Health Anti-oxidant Skin protectant
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Oleuropein Tyrosol 4-Hydroxybenzoic acid p-Cumaric acid Caffeic acid Apigenin Cinnamic acid Gallic acid Hydroxytyrosol Luteolin Quercetin
OMW Polyphenols by- products
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Example of HT Bioactivity
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OMWW Acidification Ultra- Filtration Nano- Filtration MA-HT-R
(MARS -. HT Recovery Sys.)
COD ~ 106g/l Phenol~ 3g/l TP/TOCx100~8% COD~10g/l Phenol~0.7 g/l
Product A:
Semi-purified H2O for Agri
Organic Waste
Compost
Organic Concentrate
Phenol~4.5g/l
Hydroxytyrosol Enriched Product Product B:
Food Pharma Additive Starting Material
Mobile OMWW + Membrane Contractor Pilot Plant
Preparative HPLC Final -HT Pure product
HT/TOCx100~12% NMR~ 99% PH 2
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Tyrosol-TMS Hydroxytyrosol-TMS
MS Fingerprints
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Permeate – GC-MS Spectrum
I.S
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High P pump
Membrane Contractor HT Recovery Sys. Sterlitech NF flat sheet module
UF –NF System
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NF – concentration of OMWW (sterlitech)
10 15 20 25 30 35 40 45
10 20 30 40 50 60
1 2 3 4 5 6 7 Applied P, bar J, Flux, L/m2h VCF
J DP
10 15 20 25 30 35 40 45 50 55 10 20 30 40 50 60 70
1 2 3 4 5 6
Applied P, bar J, Flux, L/m2h VCF
J DP
DK5 – 7.1 L/m2-h-bar NF270 – 12.2 L/m2-h-bar
0.5 1 1.5 2 2.5 3 3.5 4 4.5 1 3 5 7
- Sp. Flux, L/m2-h-bar
VCF DK5 NF270
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NF selectivity
0.0% 20.0% 40.0% 60.0% 80.0% 100.0% 120.0% Initial rejection Final rejection
DK5 – passes only tyrosol and
- hydroxytyrosol. Permeate was
>99% tyrosol/hydroxytyrosol! RAHAT – OMWW after UF
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NF selectivity RAHAT
NF-270 – not nearly as selective!
0.0% 20.0% 40.0% 60.0% 80.0% 100.0% 120.0%
NF-270
Final Rejn
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Dialysis cell for diffusion rate measurement
- Mem. Contractor
Hydroxytyrsol Recovery Sys.
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industries View & Basic Questions Pharma Food/ Phenols: Islated Regarding OMWW
What is the PRODUCT? ) Drug Starting Material Pharma Food Additives; ( Production process? ) > Prep. HPLC
- Combined Membrane Contractor Recovery Sys.
( Rate of purification; Quantities and Qualities? ) . Concent
- f high volume NF
ppm 500 , 4 ; ~ Hydroxytyrosol % 75 (~ Market size & vision? ) Millions Market
- Existing and Increasing Multi
( Chances to meet FDA Regulations? ) Higher Risk – Pharma Relatively High & Easy; – Food (
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FDA Regulations Approach:
Safety and nutritional quality of food sold.
Scope includes: Food labelling, advertising and claims; Food standards and compositional requirements; Foods for special dietary uses;
Food additives;
Chemical and microbial hazards; Veterinary drug residues; Packaging material; Pesticides. The role of the FDA is to protect the public against health hazards and fraud from the sale of food (including beverages), drugs, medical devices and cosmetics.
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