Natural Protection of Milk 14 th April 2016 Host Institution - - PowerPoint PPT Presentation

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Natural Protection of Milk 14 th April 2016 Host Institution - - PowerPoint PPT Presentation

Jan 30, 2023 358 likes •502 views

Natural Protection of Milk 14 th April 2016 Host Institution Allergy prevalence Allergic disease major escalating health issue Atopic dermatitis, food allergy, asthma 2 - 3% infants in 1 st year cow milk allergy 5% children

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SLIDE 1

Host Institution

Natural Protection of Milk

14th April 2016

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SLIDE 2

Allergy prevalence

  • Allergic disease major escalating health issue
  • Atopic dermatitis, food allergy, asthma
  • 2 - 3% infants in 1st year – cow milk allergy
  • 5% children develop food allergies
  • Majority ‘grow out’ of the problem
  • Persistent sensitization

= increased risk of later allergy

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SLIDE 3

The Allergic March

https://www.allergyuk.org/causes-and-risks-of-allergy/the-allergic-march

Typical age of onset

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SLIDE 4

Epidemiological studies

  • Studies in Europe and New Zealand show a

relationship between farms and allergy

  • Farming families have a decreased risk of

developing allergy

Braun-Fahrlander et al (1999), Ernst and Cormier (2000), Kilpelainen et al (2000), Riedler at al (2000), Wickens et al (2002)

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SLIDE 5

Protection from allergy

  • Exposure to barns and stables
  • Early contact with farm animals
  • Working on a farm during pregnancy
  • Consumption of unpasteurised milk

Loss et al (2011), van Neerven at al (2012), von Mutius and Vercelli (2016)

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SLIDE 6

What’s in milk?

  • Fat, protein, carbohydrates
  • Complex mixture
  • Characteristics altered by processing

proteins

30.0 g/l

whey proteins

6.0 g/l

caseins

24.0 g/l

b-lact 3.0 g/l a-lact 1.5 g/l

  • ther 1.5 g/l
  • Antibodies
  • Hormones
  • Enzymes
  • Growth factors
  • Cytokines
  • Nucleotides
  • Polyamines
  • Free amino acids
  • Free fatty acids
  • monoglycerides
  • MFGM proteins
  • Oligosaccharides
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SLIDE 7

14 28 30 32 34 days IP saline or OVA antigen Saline or OVA Sensitisation x2 Intra-gastric challenges

Can milk affect allergy responses?

Mouse model for food effects on allergy (Brandt et al 2003)

OVA = ovalbumin protein, IP= intraperitoneal injection

Raw milk Sterilised milk (γ irradiated) Heated milk Diet:

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SLIDE 8

Effects of milk treatment

Sterilised milk Heated milk Gamma irradiated Heat to 87°C and cooled Raw milk

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SLIDE 9

Effects of milk treatment

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SLIDE 10

Yes, milk affects allergy responses

2500 5000 7500 10000

Control Water Raw Sterilised Heated OVA treated MMCP-I (ng/ml)

a b b b c

5000 10000 15000

Control Water Raw Gamma Heated OVA IL-10 (pg/ml)

a b b b c

(Hodgkinson et al 2014)

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SLIDE 11

Natural protection of milk

Hypothesis:

A safe milk product, produced using special processing techniques to preserve heat-sensitive components, will retain health benefits associated with unprocessed milk.

Research Plan:

  • Models to demonstrate protective effects
  • Mechanism of action and potential biomarkers
  • Timing and duration of dose
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Natural Protection of Milk

  • Unlock the natural health benefits
  • f milk
  • In partnership with Miraka, develop

a safe product that delivers added health benefits to toddlers

  • Meet a demand from parents for

natural foods to reduce risk allergy development in their children