MOLECULAR CELL BIOLOGY CONCENTRATION Director: Dr. Alexander M. Ishov Associate Director: Dr. Eric A. Vitriol Basic Science Department: Anatomy & Cell Biology Department Chair: Dr. Yehia Daaka
What is Cell Biology? Cell biology studies cells – their physiological properties, • their structure, the organelles they contain, interactions with their environment, their life cycle, division and death Knowing the components of cells and how cells work is • fundamental to all biological sciences Therefore, research in cell biology is closely related to • genetics, biochemistry, molecular biology, immunology, and developmental biology
MOLECULAR CELL BIOLOGY CONCENTRATION Variety of research projects: Cellular structure, organization and function Microbes, insect, yeast, mammals Stem cells, somatic cells, tumor cells Transgenic animals Cell Biology of Diseases: Cancer biology and therapeutics Aging, diabetes, immunity, angiogenesis, viral infection
MOLECULAR CELL BIOLOGY CONCENTRATION • 12 Graduate students National and International • Over 60 Faculty members
MOL ECULAR CELL BIOLOGY CONCENTRATION Department Faculty Students 1) Anatomy Maria Zajac-Kaye Kelly Maeng and Cell Biology Maria Zajac-Kaye Daniel Shabasvilli Yehia Daaka Allyson Shea Yehia Daaka Joseph Black Yi Qiu Johnson, Alta Daiqing Liao Iqbal Mahmud 2) Medicine Marck Brantly George Marek 3) Mol Gen Edward Scott Anna Rodgers & Micro 4) Pathology Naohiro Terada Joonseok Cho 5) Aging Shinichi Someya Mi-Jung Kim 6) Periodontology Ozlem Yilmaz Joann Roberts Kevin Mchugh Ibraheem Bamaga
MOLECULAR CELL BIOLOGY CONCENTRATION Core IDP curriculum • Advanced MCB curriculum • Advanced Cell Biology: 4 credits, required for all MCB students, Spring semester 3 more MCB credits Journal club: • Molecular Cell Biology • Data Club: semi-monthly, 45’ presentation, 15’ discussion Regular Committee Meetings (2/year) • At least 1 first authorship paper • At least 1 poster at national/international conference •
Advanced MCB curriculum Fall Semester: Transcriptional Control of Growth & Proliferation • Organization of Cells and Tissues • Integrative Aging Physiology • Mitochondrial Biology in Aging and Disease • The Nucleus • Spring Semester: Advanced Cell Biology • RNA Interference and MicroRNAs • Protein Trafficking • Mechanisms of Aging • Stem Cell Biology • Advanced Stem Cell Biology – Regenerative Medicine • Apoptosis •
MOLECULAR CELL BIOLOGY CONCENTRATION Core IDP curriculum • Advanced MCB curriculum • Advanced Cell Biology: 4 credits, required for all MCB students, Spring semester 3 more MCB credits Journal club: • Molecular Cell Biology • Data Club: semi-monthly, 45’ presentation, 15’ discussion Regular Committee Meetings (2/year) • At least 1 first authorship paper • At least 1 poster at national/international conference •
Former MCB student: Serena Giovinazzi Mechanisms of Chemotherapy Resistance in Breast Cancer Started IDP: August 2008; Joined lab: April 2009 Publications: 1. Giovinazzi S, et al., Oncogene (2012). 2. Giovinazzi S, et al., Cell Death Differ (2013). 3. Giovinazzi S, et al., Cell Cycle (2013). 4. Giovinazzi S, et al., Oncotarget (2014) Conferences: American Society for Cell Biology 2011, 2012, 2013 American Association for Cancer Research, 2012 Awards: Gold Medal, Medical Guild Research Competition, College of Medicine, 2012 PhD dissertation: March 2012 Current Position: Postdoc, Florida State University
MOLECULAR CELL BIOLOGY CONCENTRATION Faculty and Research
L. Shannon Holliday, PhD Associate Professor of Orthodontics and Anatomy & Cell Biology Exosomes: novel regulators of bone remodeling Communication between osteoclasts (bone resorbing cells) and osteoblasts (bone forming cells) is vital for the maintenance of healthy bone. We have identified exosomes that are released from osteoclasts as novel regulators of bone remodeling. Efforts are underway to characterize the composition and regulatory activity of osteoclast-derived exosomes. Communication may involve protein signaling, mRNAs or microRNAs. Funded by R21 DE023900
Name: Shinichi Someya, PhD Assistant Professor Department of Aging and Geriatric Research Area of Research: Mechanisms of hearing loss and inner ear aging, Neurodegeneration, Mitochondrial dysfunction 12
Role of Autophagy in Cancer and Cardiovascular Disease Project 1: Autophagy is a constitutive degradative pathway necessary for cellular homeostasis, but has been exploited by some cancer cells for survival and chemotherapy resistance. We have identified and characterized a novel anti- autophagy compound that effectively suppresses the growth of osteosarcoma and prostate cancer tumors in mouse models. William A Dunn, Jr. PhD Professor, Anatomy and Cell Biology Project 2: Chronic periodontitis has been Reyes, L., et al. (2013) Deletion linked to atherosclerotic plaques and of lipoprotein PG0717 in P. cardiovascular disease. We have shown gingivalis W83 reduces that P. gingivalis , a bacterium associated gingipain activity and alters trafficking in and response by with this oral disease, subverts autophagy host cells. PloS One 8(9): causing endothelial dysfunction thereby e74230. promoting atherosclerosis. Our goal is to modulate autophagy in order to prevent Akin, D., et al. (2014) A novel this progressive disease. ATG4B antagonist inhibits autophagy and has a negative impact on osteosarcoma tumors. Autophagy. 10(11): 2021-35.
The overall research interest in my lab is to study the function and regulation of epigenetic modifiers in hematopoiesis and other normal or abnormal developmental program. Yi Qiu, Ph.D Assistant Professor Ongoing projects: • Role of histone deacetylase 6 in controlling erythrocyte enucleation processes. • Understanding the function of histone deacetylase 1 in regulating master regulators of erythroid differentiation. • The function of histone deacetylase 1 in regulating the assembly and recruitment of basal transcription machinery. • Identification of epigenetic modifiers which are required for cancer stem cells self-renewal. • Discovery of new histone deacetylase inhibitors for treatment of human cancer.
Innate immune Cytokine response response Bacteria IL-1 β LPS Flagellin PGN IL-1R MD2 TLR1/2 TLR4 TLR5 TLR2/6 CD14 High miR-21 = poor prognosis in oral cancer patients Myddosome MyD88 Macrophage ‐ specific? miR-155 formation miR-132/-212 IRAK4 IRAK2/I RAK1 miR-146a NF-kB TRAF6 CREB NF-kB Gene transcription Production of TNF- α , IL-1, IL-6 and other cytokines Edward K.L. Chan, PhD, Professor Department of Oral Biology Department of Anatomy and Cell Biology http://edward-chan.dental.ufl.edu/
The Vitriol Lab Actin polymerization Actin dynamics Actin structures Lamellipodia ALS Motor neurons Neuromuscular junctions
Research Interests: • Nuclear Structure and Function in normal and stress conditions • Mechanisms of Chemotherapy Resistance in Breast Cancer Alexander M. Ishov • Epigenetic Regulation of Gene Associate Professor, Expression Anatomy & Cell Biology E-mail: ishov@ufl.edu USP7 controls mitotic spindle assembly and chemotherapy resistance
MOLECULAR CELL BIOLOGY CONCENTRATION Questions? Contact Info: Alexander M. Ishov ishov@ufl.edu Or Eric A. Vitriol evitriol@ufl.edu
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