Kinetics PROJECT TEAM 5: VIPUL BHAT, T, RANVIR BHATIA, KATIE - - PowerPoint PPT Presentation

Controlled-Release Kinetics

PROJECT TEAM 5: VIPUL BHAT, T, RANVIR BHATIA, KATIE CAVANAUGH, ALBERT CHEN, EDWARD GELERNT, MICHAEL HILL-OLIVA, REMY KASSEM, JAI PATEL, RUCHIT PATEL, NHA-UYEN PHAM, JACK XIONG, EITAN ZLATIN TEAM LEADER: DR. CINCOTTA ASSISTANT: SUMA GONDI

Zero Order Kinetics

Diffusion and Fick’s Law

𝐾 = −𝐸 𝜖𝜒 𝜖𝑦

Hypothesis

Molecular size inversely proportional with diffusion coefficient Rate inversely proportional to molar mass Size has greater effect than polarity in diffusion

𝑤1 𝑤2 = 𝑛2 𝑛1

Hansen Solubility Parameters

Quantitative model for “like dissolves like”

(𝑆𝑏)2= 4(𝜀𝑒2 − 𝜀𝑒1)2 + (𝜀𝑞2 − 𝜀𝑞1)2 + (𝜀ℎ2 − 𝜀ℎ1)2

Membranes

Polyethylene vinyl acetate Calendar used to make films

Solutes

Alkanes Ketones Alcohols

Pentane (72.15 g/mol) 2-Butanone (72.11 g/mol) 1-Butanol (74.12 g/mol) n-Hexane (86.18 g/mol) 2-Pentanone (86.13 g/mol) 1-Pentanol (88.15 g/mol) Heptane (100.21 g/mol) 2-Hexanone (100.16 g/mol) 1-Hexanol (102.18 g/mol) n-Octane (114.23 g/mol) 2-Heptanone (114.18 g/mol) 1-Heptanol (116.2 g/mol)

• All organic compounds
• Varying polarity and size

Experimental Design and Data Collection

Data Analysis

Flux (mol/m2hr)

Thickness (m) Gas concentration (mol/L)

log10 𝑞 = 𝐵 − 𝐶 𝐷 + 𝑈

𝐸 = −𝐾 × 1 𝜖𝜒 𝜖𝑦

146.5 147 147.5 148 148.5 149 149.5

MASS (G) TIME (H)

MASS OF OCTANE SAMPLE OVER TIME

Octane 1 Octane 2

20 40 60 80 100 120 140 160 70 75 80 85 90 95 100 105 110 115 120

DIFFUSION COEFFICIENT MOLAR MASS (G)

THE EFFECT OF MASS ON DIFFUSION COEFFICIENT

Alkanes Ketones Alcohols Linear (Alkanes) Linear (Ketones) Linear (Alcohols)

20 40 60 80 100 120 140 160 72-75G/MOL 86-89G/MOL 100-103G/MOL 114-117G/MOL

DIFFUSION COEFFICIENT COMPOUND GROUPING BY MOLAR MASS (G/MOL)

THE EFFECT OF POLARITY ON DIFFUSION COEFFICIENT

Alkanes Ketones Alcohols

Discussion and Analysis

Consistent pseudo-zero-order diffusion achieved Positive correlation between size and diffusion coefficient Positive correlation between polarity and diffusion coefficient

Alkanes Ra Ketones Ra Alcohols Ra Pentane 10.1 2-Butanone 5.6 1-Butanol 9.5 n-Hexane 9.7 2-Pentanone 4.7 1-Pentanol 7.8 Heptane 9.3 2-Hexanone 5.3 1-Hexanol 6.6 n-Octane 9.1 2-Heptanone 3.9 1-Heptanol 5.7

2 4 6 8 10 12 5 10 15 20 25 20 40 60 80 100 120 140 160 2 4 6 8 10

ALKANE RA VALUES ALKANE DIFFUSION COEFFICIENT ALCOHOL DIFFUSION COEFFICIENT ALCOHOL RA VALUES

DIFFUSION COEFFICIENT AS RA VALUE INCREASES

Alcohols Alkanes Linear (Alkanes) Linear (Alkanes)

Future Studies

Improving data collection and film making methods Studying different membrane makeups Running more trials on pure organic liquids Testing diffusion of larger and smaller organic compounds

Conclusion

Observations do not support hypothesis

• Polarity has greater influence on diffusion than molecular size

Results explained by membrane compatibility

Acknowledgements

Team 5 would like to thank…

• Dr. David Cincotta, team leader
• Suma Gondi, assistant
• Dr. Adam Cassano & Dr. Steve Surace, co-

directors

• New Jersey Governor’s School
• Drew University
• Past Team 5s

for assisting us with our research and providing us with an amazing experience. Team 5 would also like to thank…

• The Overdeck Family Foundation
• AT&T
• Bayer Healthcare
• Independent College Fund of New

Jersey/Johnson & Johnson

• NJGSS Alumnae, Parents, and Corporate

Matching Funds

• The State of New Jersey
• Board of Overseers, New Jersey Governor’s

School

for their generosity.

Thank you for listening!