INCI : Aqua (Water), Panthenol, Hydroxipropyl Methylcellulose, Ginkgo - - PDF document

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HAIRZON – 10 amp x 2ml INCI: Aqua (Water), Panthenol, Hydroxipropyl Methylcellulose, Ginkgo Biloba Root Extract, Biotine, Carboxyethyl Aminobutyric Acid (Cegaba), Sodium Benzoate, Caffein, Sodium Hydroxide, Sodium Hyaluronate, Adenosine Triphosphate, Copper Tripeptide-1, Leucine, Valine, Arginine HCI, Glutamine. ACTIVE INGREDIENT FUNCTIONS Panthenol Active form of Vitamin B5. Increased mitotic activity of the skin. Hydroxipropyl Methylcellulose Stabilizer. Ginkgo Biloba Root Extract Activates blood circulation and revitalizes the growth

• f new hair.

Biotine It is acting in revitalizing the hair bulb growth and making having a greater thickness and strength. Carboxyethyl Aminobutyric Acid (Cegaba) Polyamines derived molecule. Causes increased proliferation of hybridomas culture. Sodium Benzoate Preservative. Caffein It stimulates hair growth and prevents its fall. Sodium Hydroxide Surfactant. Sodium Hyaluronate Moisturizing (forms a visco elastic layer thanks to its high capacity to retain water). Adenosine Triphosphate Energizes and hydrates the cells, functions essential to prevent or reverse the process aging. Copper Tripeptide-1 Amino Acid: stimulates hair growth. Leucine Essential amino acid: It stimulates the synthesis of

• proteins. It is part of Natural Moisturizing Factor.

Valine Essential amino acid: It stimulates the synthesis of

• proteins. It is part of Natural Moisturizing Factor.

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Arginine HCI Glutamine Essential amino acid: It stimulates the synthesis of

• proteins. It is part of Natural Moisturizing Factor.

Physico-chemical Specifications Transparent brown liquid with characteristic odor.

• Ph: 7±1
• Presentation: amber glass vial
• Volume: 2 ml

Main regenerative antifall properties.

• CEGABA 10 % (Carboxyethyl gamma-aminobutiryc acid). Thanks to its activity as a

growth factor, CEGABA is able to stop and reverse the hair fall. (Scientifically tested). Through a series of non-hormonal mechanisms it prolongs and activates the hair growth phase, it strengthens the hair follicles making them more resistant and it reduces the amount of sebum and dandruff on the scalp.

• CAFEINE. Caffeine has been identified as a stimulator of human hair growth in vitro,

and reduced testosterone-induced follicle growth suppression.

• COPPER PEPTIDE. The copper peptides revert the natural processes, leading to the

generation of new blood vessels around the follicle, as well as to an increase of subcutaneous fat and melanin synthesis, beyond the damage to regenerate scalp, promoting the formation of thicker hair.

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ANNEX 1 CEGABA AS A GROWTH FACTOR (Professor Fussi). The CEGABA activity as a promoter of cell growth has been demonstrated in several studies carried out first by Curti and Fussi, and later by G. Forni and J. Guardiola. A study published in the Journal of Immunological Methods by Cerino A, de Amici M, Fussi FF, Astaldi Ricotti GC, about CEGABA as a growth factor for hybridomas, achieved the following conclusions. CEGABA (carboxyethyl gamma-aminobutyric acid), a molecule derived from polyamines, causes an increase in the proliferation of Hybridomas in vitro. Compared to other growth factors, the effects and mechanism of action of CEGABA and CR- ECGS (endothelial cell growth supplement) on Hybridomas growth are of a similar nature. However, both factors are less effective than HECS in inducing growth of hybridoma through every step of hybridoma production, including: recovery after the merger, donation and

• proliferation. This shows that they can act as growth factors in a general and less specific

way than in the case of HECS. This in vitro study, shows the stimulation capability of cell growth and the prolongation of long term survival induced by CEGABA, that it is nevertheless not affected by other problems caused by polyamines such as the high concentrations required to achieve significant cell growth rates. Thanks to its activity as a growth factor, CEGABA is able to stop and reverse the hair fall. (Scientifically tested). CEGABA has a direct effect on the production of cells in culture, thus it is thought that its mechanism of action directly affects to cells of the dermal papillae or germinal matrix. Through a series of non-hormonal mechanisms it prolongs and activates the hair growth phase, it strengthens the hair follicles making them more resistant and it reduces the amount of sebum and dandruff on the scalp. This makes the hair lasts longer, grow ever stronger and thicker and prevents the death of the follicles. It can be applied in different types of alopecia since its mechanism of action involves the stimulation of cell growth. In addition it is also indicated for women and it does not cause any secondary or side effects.

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ANNEX 2 CAFFEINE Caffeine has been identified as a stimulator of human hair growth in vitro, and reduced testosterone-induced follicle growth suppression. It has been demonstrated that the addition of caffeine to a shampoo-formulation is effective in administering caffeine to the hair follicles in the scalp. Further research must be done to evaluate the efficacy and adequate dosage of caffeine in the treatment of androgenetic alopecia. A spray made with coffee beans is claimed to prevent age-related hair loss in women.

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ANNEX 3 COOPER PEPTIDES As it is well known, during youth hair is abundant and the hair follicles are well supplied by blood vessels. However, during aging, it is been verified that the process of follicles regeneration, abundantly irrigated before, starts to slow down. In a man, the action of the hormone dihydrotestosterone (the major responsible for male baldness pattern) represents an added obstacle to the growth of hair. It is also known that the effect of the process of miniaturization of hair follicles leads to a progressive baldness with always more superficial hair and less irrigated by blood. The direct consequence of this progressive "decrease" of the hair bulb leads to a growth of always thinner and more fragile hair and without pigmentation. What is the use of copper peptides to combat baldness? Copper peptides, patented by Loren Pickart in the 80's, thanks to its many virtues, are among the substances that contribute best to lock or revert the process of miniaturization of the follicles. According to Pickart the processes of renewal of the skin and scalp are made through hair follicles, as new skin cells emerge from the hair follicles and migrate to the skin of the regions that surround them. Pickart states that the action of copper peptides would be able to reverse the natural aging process of skin and hair follicles, characterized by fine, miniaturized hair, thinner scalp and longer telogen phases. Among the causes of accelerated aging skin and hair processes, chemical factors and / or environmental factors such as the action of chemical and cosmetic stains, excessive exposure to heat and ultraviolet rays damage the scalp other nature (scar) and autoimmune action of the body have also been also mentioned. It was noted that the action of copper peptides would revert those natural processes, leading to the generation of new blood vessels around the follicle, as well as to an increase

• f subcutaneous fat and melanin synthesis, beyond the damage to regenerate scalp,

promoting the formation of thicker hair. These effects were first observed in the 40's during the Second World War, when it was verified as a prognosis device in the cure process of patients affected by grave burns and

• scars. Observation of the hair follicles apart from the burnt skin became determinant since if

the follicles tended to widen the cure would be scarce and the scars would remain.

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Later, in 1985, Pickart found that not only did his copper peptides, the SRCPs (Skin Remodeling Copper Peptides) stimulate the healing of wounds, but they also increased the size of hair follicles in areas hit by them. Therefore it was concluded that apart from being growth stimulators in themselves, this growth driven by copper peptides represents a natural consequence of increased vitality and health of the hair follicle. Copper peptides complement the hair transplant to stimulate the conversion of fine hair in pigmented hair thicker and, through its action on the hair follicle.