Imaging Monoaminergic Systems and their Pharmacological Control - PowerPoint PPT Presentation

Context Technology Fingerprinting Psychopharmacology Meta Supplementary Imaging Monoaminergic Systems and their Pharmacological Control Horea-Ioan Ioan˘ as , [ chymera.eu ] Institute for Biomedical Engineering, ETH and University of Zurich August 14, 2019 Horea-Ioan Ioan˘ as Institute for Biomedical Engineering, ETH and University of Zurich , Imaging Monoaminergic Systems and their Pharmacological Control

Context Technology Fingerprinting Psychopharmacology Meta Supplementary Rationale, background, and aims How can neuroscience change the world? ◮ Facilitate the betterment of the human mind. ◮ Establish natural scientific definitions of mental phenomena. ◮ Create reusable methods which empower other research. Horea-Ioan Ioan˘ as Institute for Biomedical Engineering, ETH and University of Zurich , Imaging Monoaminergic Systems and their Pharmacological Control

Context Technology Fingerprinting Psychopharmacology Meta Supplementary Rationale, background, and aims Monoaminergic Systems ◮ Widely implicated in emotional function ◮ Widely implicated in mental diseases ◮ High degree-centrality brain nodes Monoamine-centric representation of Ascending serotonergic (5HT) projections. emotional states, from [1] Horea-Ioan Ioan˘ as Institute for Biomedical Engineering, ETH and University of Zurich , Imaging Monoaminergic Systems and their Pharmacological Control

Context Technology Fingerprinting Psychopharmacology Meta Supplementary Rationale, background, and aims Monoaminergic Pharmacology ◮ Popular targets of psychotropic drugs, including such as are: ◮ therapeutic ◮ neuroenhancing ◮ recreational ◮ addictive Notable molecular homology at monoaminergic synapses, from [2] Horea-Ioan Ioan˘ as Institute for Biomedical Engineering, ETH and University of Zurich , Imaging Monoaminergic Systems and their Pharmacological Control

Context Technology Fingerprinting Psychopharmacology Meta Supplementary Rationale, background, and aims Aims ◮ Develop technologies to automate and reproduce assays. ◮ Establish novel monoaminergic imaging assay — “endophenotype”. ◮ Determine psychopharmacological susceptibility of imaging assay. Horea-Ioan Ioan˘ as Institute for Biomedical Engineering, ETH and University of Zurich , Imaging Monoaminergic Systems and their Pharmacological Control