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Hippocampal-prefrontal plasticity seems to reverberate in a - - PowerPoint PPT Presentation
Hippocampal-prefrontal plasticity seems to reverberate in a - - PowerPoint PPT Presentation
Hippocampal-prefrontal plasticity seems to reverberate in a thalamic-prefrontal loop: what else neuromathematics could tell us? Lzio S. Bueno-Jnior Joo P. Leite Medical School of Ribeiro Preto 1/5 First, the structure: a particular
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Then, its (hypothetical) function... ...from a phenomenological perspective.
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Lastly, its mathematical exploration... ...and extrapolation.
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Bueno-Júnior et al. (2012) – PLoS One v. 7 Lopes Aguiar et al. (2013) – Neuropharmacology v. 65
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2/5 Thalamus Neocortex Hippocampus
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CA1/ subiculum Limbic thalamus Prefrontal cortex
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CA1/ subiculum Limbic thalamus Prefrontal cortex
Slow-wave sleep or deep anesthesia
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CA1/ subiculum Limbic thalamus Prefrontal cortex
REM sleep or the awake state
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CA1/ subiculum Limbic thalamus Prefrontal cortex
REM sleep or the awake state
What now?
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CA1/ subiculum Limbic thalamus Prefrontal cortex
Rec Rec
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Caudal Rostral
MD thalamus recording PF cortex recording CA1/sub stimulation
Perfusion
120 min
HFS
30 min
Baseline Post-HFS monitoring
...
80 ms 10 s
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Some descriptive statistics
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- 0.2
0.2 0.4 0.6 0.8 1.0
Perievent time (s)
30 60 90 120 150
- 0.2
0.2 0.4 30 60 90 120 150
Recording length (min)
PF cortex
40 spikes ISI 200 ms 1,19 Hz 1 ms 60 μV
- 0.2
- 0.1
0.1 0.2
Firing rate (Z score) Baseline Early monit Late monit
800 spikes ISI 200 ms 1 ms 3,09 Hz 70 μV
- 0.2
0.2 0.4 0.6 0.8 1.0
Perievent time (s)
- 0.4
0.4 0.8 30 60 90 120 150
- 0.2
0.2 0.6 1 30 60 90 120 150
MD thalamus
4/5
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- 0.2
0.2 0.4 0.6 0.8 1.0
Perievent time (s)
30 60 90 120 150
- 0.2
0.2 0.4 30 60 90 120 150
Recording length (min)
PF cortex
40 spikes ISI 200 ms 1,19 Hz 1 ms 60 μV
- 0.2
- 0.1
0.1 0.2
Firing rate (Z score) Baseline Early monit Late monit
800 spikes ISI 200 ms 1 ms 3,09 Hz 70 μV
- 0.2
0.2 0.4 0.6 0.8 1.0
Perievent time (s)
- 0.4
0.4 0.8 30 60 90 120 150
- 0.2
0.2 0.6 1 30 60 90 120 150
MD thalamus
Some descriptive statistics
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Only two neurons!?
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MD thalamic neurons did respond to hippocampal pulses: phasic excitation then transient inhibition PF cortical responses were subtler and slower: inhibition then excitation HFS-favored HFS-dependent
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20 60 100 140
Baseline Early monit Late monit
- 0,2
- 0,1
0,1 0,2 0,3
Voltage (mV)
- 20
20 60 100 140
Perievent time (s)
fPSP nº 1 nº 2
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- 5
5 10
Recording length (min)
30 60 90 120 150
PF cortex
nº 1 nº 2
MD thalamus
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CA1/ subiculum Limbic thalamus Prefrontal cortex
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CA1/ subiculum Limbic thalamus Prefrontal cortex
…or the spread of epileptic seizures? Do they have something to do with working memory…? ...modulated by the sleep-wake cycle? Non-motor (i.e., cognitive) efference copies...?
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5/5 Thalamus Neocortex Hippocampus
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5/5 Thalamus Neocortex Hippocampus
Sleep-wake? Working memory? S u b c l i n i c a l p a r
- x
y s m s ?
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