Function preservation with Image Adapted Brachytherapy (IABT) N. - - PowerPoint PPT Presentation

▶
function preservation with image adapted brachytherapy
SMART_READER_LITE
LIVE PREVIEW

Function preservation with Image Adapted Brachytherapy (IABT) N. - - PowerPoint PPT Presentation

Nov 17, 2022 281 likes •440 views

Function preservation with Image Adapted Brachytherapy (IABT) N. Dinapoli The eyelid question: Brachytherapy in non melanoma skin cancer Uncommon tumor Small anatomy Surgery as gold standard Brachytherapy as conservative

slide-1
SLIDE 1

Function preservation with Image Adapted Brachytherapy (IABT)

  • N. Dinapoli
slide-2
SLIDE 2

The “eyelid question”: Brachytherapy in non melanoma skin cancer

  • Uncommon tumor
  • Small anatomy
  • Surgery as gold standard
  • Brachytherapy as conservative

approach or for surgery unfit patients

slide-3
SLIDE 3

The “eyelid question”: Brachytherapy in non melanoma skin cancer

  • Basal cell carcinoma (BCC): 90%
  • Squamous cell carcinoma (SCC)
  • Sebaceous cell carcinoma
  • Merkel cell tumour
slide-4
SLIDE 4

The “eyelid question”: Brachytherapy in non melanoma skin cancer Lower-eyelid 50-60%

Medial canthus 25-30%

Other sites 25-10%

slide-5
SLIDE 5

NMSC – Therapeutic options

  • Surgery
  • Radiotherapy
  • Cryotherapy
  • Curettage
  • Electrodissection
  • Photodynamic therapy
  • Laser ablation

Murchison AP, Clin Experiment Ophthalmol. 2011

slide-6
SLIDE 6

NMSC – Therapeutic options

  • Surgery: gold standard
  • Radiotherapy
  • Cryotherapy
  • Curettage
  • Electrodissection
  • Photodynamic therapy
  • Laser ablation

Murchison AP, Clin Experiment Ophthalmol. 2011

slide-7
SLIDE 7

NMSC – Therapeutic options

  • Surgery
  • Radiotherapy: surgical unfit patients
  • Cryotherapy
  • Curettage
  • Electrodissection
  • Photodynamic therapy
  • Laser ablation

Murchison AP, Clin Experiment Ophthalmol. 2011

slide-8
SLIDE 8

NMSC – Treatment aims

  • Tumor control
  • Function preservation
  • Cosmetic results
slide-9
SLIDE 9

BRT in NMSC of eyelid

Frakulli R, J Contemp Brachytherapy. 2015

slide-10
SLIDE 10

BRT in NMSC of eyelid

Frakulli R, J Contemp Brachytherapy. 2015

  • No randomized trials
  • No systematic reviews
  • No metanalyses
slide-11
SLIDE 11

BRT in NMSC of eyelid: treatment

Frakulli R, J Contemp Brachytherapy. 2015

  • LDR: 249/243
  • HDR: 45/45
slide-12
SLIDE 12

BRT in NMSC of eyelid: outcomes

Frakulli R, J Contemp Brachytherapy. 2015

  • Excellent Local Control: 75.6% - 100%
slide-13
SLIDE 13

BRT in NMSC of eyelid: outcomes

Frakulli R, J Contemp Brachytherapy. 2015

  • High rate of optimal functional outcome despite

presence of some frequent late toxicity (epilation)

slide-14
SLIDE 14

BRT in NMSC of eyelid: conclusions

Frakulli R, J Contemp Brachytherapy. 2015 Mareco V, Brachytherapy. 2015

  • LC is reported as crude rate (except for one paper)
  • LC rate are good (75.6% - 100%)
  • Despite lack of unique toxicity and functional reporting

scale toxicity and functional outcome seem accetable

  • Cosmetic/functional outcome seem related to overall

dose (reported as V100>2cc, or V150>1cc)