Final Action Meeting Eilat, Israel in November 2016 Action BM1203 - - PowerPoint PPT Presentation
Final Action Meeting Eilat, Israel in November 2016 Action BM1203 (EU-ROS) Chair Prof. Andreas Daiber COST Domain - Biomedicine and Molecular Biosciences (BMBS) Mission of COST The COST program (European Cooperation in Science and Technology)
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6 Casas et al. or Schmidt et al., Antioxid. Redox Signal. 2015
7 Daiber, Di Lisa et al. Br. J. Pharmacol. 2015
8 Modified from Daiber, Biochim. Biophys. Acta 2010
9 Schulz et al. and Daiber, Antioxid. Redox Signal. 2014
New antioxidant drugs
10 Vi Dao et al. Antioxid. Redox Signal. 2015
In vivo RONS imaging
11 Maulucci et al. Antioxid. Redox Signal. 2016
Redox biomarkers
12 Frijhoff et al. Antioxid. Redox Signal. 2015
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Author teams Status Manuscript Title Notes Fabio Di Lisa, Rainer Schulz, Peter FerdAccepted and Exported New aspects on P66Shc in ischemia/reperfusion injury and protection from it Andreas Daiber, Huige Li, Santiago Lam Accepted and Exported Targeting endothelial dysfunction Gabriella Aviello, Ulla Knaus, … Accepted and Exported Gastrointestinal Inflammation and ROS (Crohn's, ulcerative colitis, ileitis...) Serge Bottari, Neven Zarkovic, Olha Yel Accepted and Exported Biomarkers of oxidative and nitro‐oxidative stress Andreas Daiber, Fabio Di Lisa, MatthiaAccepted and Exported Effects of the crosstalk of mitochondria with NADPH oxidase on endothelial dysfunction and vascular inflammatio Huige Li et al. Accepted and Exported Antioxidant effects of resveratrol in the cardiovascular system Jeanette Marjorie Wood et al. Accepted and Exported Therapeutic potential of NOX1/4 inhibitors Gethin J. McBean, Javier Egea, Manuel Accepted and Exported Redox‐based therapeutics in neurodegenerative disease Jankovic A, Korac A, Buzadzic B, Stancic Accepted and Exported Targeting the nitric oxide/superoxide ratio in adipose tissue ‐ relevance in obesity and diabetes management Pavel Urbanek and Lars‐Oliver Klotz Accepted and Exported Posttranscriptional regulation of FoxO formation Frederik Vilhardt et al Accepted and Exported NADPH oxidases in Microglia oxidant production: Activating Receptors, Pharmacology, and Association with Disea Frederik Vilhardt et al Accepted and Exported Microglia Antioxidants and Redox signaling Sebastian Steven et al. Accepted and Exported Glucagon‐like peptide‐1 receptor signalling reduces microvascular thrombosis, nitrosative and oxidative stress, … Piero Ghezzi, Vincent Jaquet, Fabrizio Accepted and Exported The oxidative stress theory: Demystifying the evidence for reactive oxygen species in physiology and disease Görlach A, Dulak J, Kietzmann T, Poelli Accepted and Exported Epigenetics and redox stress Ioanna Andreadou, Peter Ferdinandy Accepted and Exported Effect of hyperlipidemai on the heart: importance of oxidative stress
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24 Mikhed, Görlach, Knaus, Daiber, Redox Biol. 2015
Oxidation of thiols in Keap‐1
AP‐1, IκB thiol redox
Prolyl hydroxylases
center
DNA methylation
Processing of 5‐ chloroC to 5‐mC
25 Urbanek and Klotz, Br. J. Pharmacol. 2016
26 Pajares et al. and Cuadrado, Redox Biol. 2015
27 Görlach et al., Redox Biol. 2015
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Challenges and draw-backs
very high due to the number of active members
Chances
attractive pharmacological applications
integration is pivotal not only for attracting the interest of the scientific community, but also for achieving a broad consensus on messages and guidelines to be delivered to the general public. This might be especially relevant in the case of nutritional and therapeutic aspects of oxidative stress and use of antioxidants.
clinical applications. In addition, oxidative stress and redox signalling are relevant topics for many other research fields. Therefore, successful collaborations with other COST Actions (BM1005 and CM1001) were established, also because there was some overlap in the members of these COST Actions.