disease network Kwang-Il Goh, Michael E. Cusick, David Valle, - - PowerPoint PPT Presentation

The human disease network

Kwang-Il Goh, Michael E. Cusick¶, David Valle, Barton Childs, Marc Vidal, and Albert-La´ szlo´ Baraba´ si A presentation by Niklaas Nilson

Genetic mutation  deafness

locus heterogeneity allelic heterogeneity different mutations same mutation same disorder different disorders

Human “disease phenotype” Human “disease genome” “Diseasome”

1284 disorders 1777 disease genes 22 disorder classes

The Potential of HDN and DGN

The Potential of HDN and DGN

Functional Clustering of HDN and DGN

Disease-associated genes identify distinct Functional Modules

Centrality and Periphery

• In S. Cereviseae highly

connected Proteins (“hubs”) are more likely encoded by essential genes

• Does human disease genes

also have the tendency to encode hubs?

Centrality and Periphery

• First analysis say yes
• Disease related proteins have a

32% larger number of interactions to other Proteins than nondisease Proteins

• And high-degree-proteins are

more likely encoded by genes associated with diseases than

• ther proteins

Centrality and Periphery

• Essential proteins show a

tendency to be associated with “hubs” (c)

• Question: is the correlation

between “hubs” and disease genes driven by the fact that a small number ob these genes is essential?

Centrality and Periphery

• Correlation between

nonessential genes and “hubs” disappears

Conclusion

• This network gives the
• pportunity to study all human

diseases at once

• It´s a very elegant way for data-

analysis