Disclosures UCSF Controversies in Womens Health 2016 December 8, - - PDF document

disclosures
SMART_READER_LITE
LIVE PREVIEW

Disclosures UCSF Controversies in Womens Health 2016 December 8, - - PDF document

Disclosures UCSF Controversies in Womens Health 2016 December 8, 2016 I have nothing to disclose Common Activity-Related Conditions in Women Cindy J. Chang M.D. UCSF Primary Care Sports Medicine Associate Clinical Professor of


slide-1
SLIDE 1

UCSF Controversies in Women’s Health 2016

December 8, 2016

Common Activity-Related Conditions in Women

Cindy J. Chang M.D.

UCSF Primary Care Sports Medicine Associate Clinical Professor of Orthopaedics and Family and Community Medicine

Disclosures

I have nothing to disclose

Objectives

n

Discuss common activity-related conditions in women

n

Review treatment and prevention plans for these conditions

n

Identify possible areas

  • f controversy in the

diagnosis and management of these conditions

17 pages long!

slide-2
SLIDE 2

Common Reasons Not To Exercise

n I don’t have the

time

n I don’t like to sweat n I’ll look silly n I don’t know what

to do

n It’s not important n It hurts n I will get hurt

Activity-Related Conditions

Musculoskeletal I njuries

n

Anterior Cruciate Ligament (ACL) injuries

n

Patellofemoral Dysfunction (PFD)

n

Greater Trochanteric Pain Syndrome

n

Stress Fractures Activity-Related Medical Conditions

n

Female Athlete Triad

u Amenorrhea

F Menstrual dysfunction

u Disordered Eating

F Low energy availability

u Osteoporosis

F Low bone density

Important Points re: MS Injuries

n

With a good history…you should arrive at the correct diagnosis 90% of the time

Or at least a confident top 3 differential!

n

With a good history, and comfortable knowledge of basic anatomy…it will make your exam focused, quick and efficient

u And give you more time to chart…

n

With a good history, and comfortable knowledge of basic anatomy, you will not need to palpate until the END of the exam…

u Or you risk your patient not letting you finish the

exam!

History, History, History!

1.

Age, occupation, etc.

2.

Date of injury/symptom onset

3.

Injury Mechanism:

a.

Acute: pop, ability to continue activity

b.

Chronic/Overuse: precipitating activity

4.

Swelling: location and timing

5.

Symptoms: Mechanical/Other

a.

Locking, clicking, grinding, weakness, instability

6.

Symptoms: Pain/Numbness/Tingling

a.

Location - Point to where it is

b.

Radiation - come from or go anywhere else

c.

Type - burning, sharp, dull, achy, constant, at night, w/ activity or position, Grade pain

7.

Modifying/Other Factors

a.

Better/worse, previous injury/surgery, any red flags

slide-3
SLIDE 3

Knee Injury

n

30 yo female playing in family Thanksgiving Day touch football game

n

Tackled by her brother and her knee twisted under her

n

Now seeing you 1 week later and she is using an ACE wrap and borrowed cane

Which next question would be the least valuable in terms of determining the diagnosis?

  • 1. How long did it take before it swelled?
  • 2. Were you able to continue playing?
  • 3. Does your knee “give way”?
  • 4. Did you feel a pop?

Acute Knee Injury

n

30 yo female playing in family Thanksgiving Day touch football game

n

Tackled by her brother and she felt a pop as her knee twisted under her

n

Hard to put weight on leg and was unable to continue playing

n

The knee swelled “like a melon” within 2 hours despite ice

n

Her knee shifts when she puts more weight on it

n

Now seeing you 1 week later and using an ACE wrap and borrowed cane

Acute Knee Injury

n

Differential Diagnosis

u Ligament tear

F ACL tear F MCL tear F Less likely LCL tear, PCL tear

u Meniscus tear u Patellar dislocation u Bone contusion/Fracture u Tendon rupture u Chondral injury

slide-4
SLIDE 4

Knee Anatomy Anterior Knee Medial Knee Lateral Knee

slide-5
SLIDE 5

Knee – Posterior Acute Knee Injury

n Physical Exam

u + Effusion u Ligament stability

F + Lachman F - Posterior drawer

ACL Tear Anatomical Differences

slide-6
SLIDE 6

Hormonal Factors

u? u?

Conditioning and Experience

n No difference in

conditioning

n No relationship of

injury rate to NCAA division

n No difference in

prior organized sport experience

Muscle Strength and Recruitment

n Female athletes:

u Land with greater

total valgus motion

u Weaker hip

extensors

u Less hamstring

activation

u Significantly less

muscle strength and endurance

F Even when corrected

for body weight

Neuromuscular Factors

uChappell et al 2002

slide-7
SLIDE 7

“Take 3 to Save the Knee”

n Accentuate balanced body motion n Control limb rotation n Land with bent knee and hip n PEP (Prevent injury and Enhance Performance)

u 2-3x/week for 15 min u 88% decrease in ACL tears u Incidence rate of 1.7 in control /0.2 in enrolled

Non-Traumatic Knee Injury

n

40 yo female joined a gym in January with her partner

n

Began working with a personal trainer and they started a program of Olympic lifting (squatting, cleans) and plyometrics (box jumps)

n

After 2 weeks she began having left knee pain after workouts but continued training

n

Now seeing you 2 weeks later because now it hurts during training and even with walking, especially on the stairs

n

Often feels “stuck” and clicks

Patellofemoral Dysfunction

n

Will point to kneecap region

n

Pain associated with running, lunging, squats

n

Pain with sitting for prolonged period

n

Pain going down stairs may be worse than up stairs

n

Soft tissue swelling often described as puffiness

slide-8
SLIDE 8

Patellofemoral Dysfunction

n

Positive patellar compression test

n

Pain on palp of medial facet of patella

n

Increased patellar mobility

Patellofemoral Dysfunction Treatment

n Quadriceps strengthening

u Straight leg raises u Leg extensions

Patellofemoral Dysfunction Patellofemoral Dysfunction

n

Thomas test to evaluate tight hip flexors, quads, ITB

slide-9
SLIDE 9

Patellofemoral Dysfunction

n

Single Leg Squat to evaluate for weak quads, gluts

Patellofemoral Dysfunction

n Evaluate feet as well

Patellofemoral Dysfunction Treatment

n

Stretching to achieve biomechanical balance

n

Strengthening of gluteus medius

n

Proper shoewear or support

n

Patellar knee bracing

Hip Pain

n

50 year old female begins training for a half marathon with her daughter

n

She begins to experience hip pain

n

She comes in for “an injection” so she can continue training

n

The race is in one month

n

She points to her lateral hip as area of pain

slide-10
SLIDE 10

Greater Trochanteric Pain Syndrome Greater Trochanteric Pain Syndrome Greater Trochanteric Pain Syndrome

Knee Pain

n

25 year old female training for her 10th half marathon this year; this one she is running with her 50 yo mother to celebrate their birthdays

n

She begins to experience knee pain when running

n

She comes in for “an injection”; it “has to be done today” so she can continue training

n

She had patellar tendinitis x 1 month and she just resumed training 2 wks ago

n

The race is in one month. She doesn’t want to disappoint her mom or herself and “has to race”

n

When you ask where she hurts, she points to her lateral knee and patellar tendon but then also anterior hip, lateral hip, buttocks, groin

slide-11
SLIDE 11

Anatomy Anterior Hip

Which of the following is NOT an increased risk factor for a stress fracture in this patient?

  • 1. If she is of Caucasian ethnicity
  • 2. If she has oligomenorrhea
  • 3. If she is a lacto-ovo vegetarian
  • 4. If she has inadequate caloric intake
  • 5. If she has rapidly increased the volume

and intensity of training

Knee/Hip Pain

n

Insidious onset of pain

n

No history of trauma

u Her knee hurt first u Then 3 days ago maybe pulled

a hip flexor from hill running?

n

Improves with rest, worsens with loading

n

Location can be variable on any given day

n

+ Hop test

n

+ Fulcrum test

Imaging of the Hip

  • AP and frog pelvis
  • MRI of hip
slide-12
SLIDE 12

Stress Fracture Management

Site of Fx % healed at 2 - 4 w ks % healed at 1 - 2 m o. % healed at > 2 m o. Tibia, prox 1/3 43 57 Tibia, mid 1/3 48 52 Tibia, dist 1/3 53 47 Fibula 7 75 18 Metatarsals 20 57 23 Sesamoids 100 Femur, shaft 7 7 86 Femur, neck 100 Pelvis 29 75 Olecranon 100 Brukner P, Sports Med 1997

Additional Management…

n

This 20 yo female

u is of Caucasian ethnicity u has oligomenorrhea u is a recent vegen u often skips breakfast and delays dinner if it

interferes with training

u had rapidly increased the volume and intensity

  • f training after her patellar tendon injury to try

to prepare for the race

n

What additional questions would be helpful in terms of managing her stress fracture?

What combination of questions would be most helpful in managing this injury?

1.

Her highest body weight at her current height, and her pre-race meal?

2.

If ever had regular menses, and her lowest body weight at her current height?

3.

Why become a vegan, and other stress fractures?

4.

Other stress fractures, and her ideal weight?

5.

Her post-race recovery food, and her weight when she started her menses?

Female Athlete Triad

1997

slide-13
SLIDE 13

Female athlete triad

2007

uHealthy energy

status

uHealthy

menstrual cycles

uHealthy

bones

uLow energy

availability with or without eating d/o

uOsteoporosis uAmenorrhea uLow bone

density

uSuboptimal

energy availability

uIrregular

menses OPTIMAL HEALTH PATHOLOGY

Energy Balance

n

Trend among athletes toward inadequate energy intake without the presence of a clinical eating disorder

n

The imbalance of energy intake and energy expenditure results in low energy availability

n

There may be nothing “left over” for other body functions

Energy Balance

Fem ale Athlete Triad

RED-S

DSM-4 vs. DSM-5

n

Anorexia Nervosa (AN): No longer requires

am enorrhea to be a diagnostic criterion

n

Bulimia Nervosa (BN): Reduces frequency of binge

eating and compensatory behaviors to once a w eek instead of twice weekly

n

Binge Eating Disorder ( BED) now a separate

diagnosis

n

Eating Disorder Not Otherwise Specified ( EDNOS) has been rem oved

u Other Specified Feeding or Eating Disorder (OSFED) u Unspecified Feeding or Eating Disorder (UFED)

slide-14
SLIDE 14

Anorexia Nervosa (AN)

Primarily affects adolescent girls and young women

n

excessive dieting leads to severe weight loss

n

pathological fear of gaining weight or becoming fat; interferes with weight gain

n

characterized by distorted body image

Bulimia Nervosa (BN)

n

Recurrent episodes of binge eating; characterized by:

u Eating, in a discrete

period of tim e (e.g. within any 2-hour period), an am ount

  • f food that is

larger than most people would eat

u A sense of lack of

control over eating during the episode

n

Recurrent inappropriate com pensatory behavior, such as self- induced vomiting, misuse of laxatives, diuretics, or other medications, fasting, or excessive exercise.

n

The binge eating and behaviors both occur,

  • n average, at least
  • nce a w eek for three

m onths.

n

Self-evaluation is unduly influenced by body shape and weight.

Binge Eating Disorder (BED)

n

Recurring episodes of eating significantly more food in a short period of time than most people would eat under similar circumstances

u episodes marked by

feelings of lack of control

n

Associated with marked distress

n

Occurs, on average, at least once a week over three months.

n

These episodes associated with ≥ 3:

u eating much more

rapidly than normal

u eating until feeling

uncomfortably full

u eating large amounts of

food when not feeling physically hungry

u eating alone because of

feeling embarrassed by how much one is eating

u feeling disgusted with

  • neself, depressed or

very guilty afterward

uNOT associated with purging, fasting, excessive

exercising, or laxative

Prevalence in General Population

n

AN: Lifetime prevalence 0.5% to 1%

u The crude mortality rate (CMR) is approximately 5%

per decade

n

BN: Lifetime prevalence 1% to 5%

u The CMR is nearly 2% per decade

******************************************

n

Those who engaged in dieting, unhealthy and extrem e w eight control behaviors, and binge eating during adolescence w ere at increased risk 1 0 years later

uNeumark-Sztainer D et al, JADA 2011

slide-15
SLIDE 15

Prevalence in Adolescent Population

n

Cross-sectional survey of adolescents ages 13-18 yoa

u Lifetime prevalence estimates of AN, BN and BED

were 0.3%, 0.9%, and 1.6%

n

Significant ethnic differences emerged for BN, w ith Hispanic adolescents reporting the highest prevalence

u trend toward ethnic minorities reporting more BED,

while non-Hispanic white adolescents tended to report more AN

uSwanson SA et al, Arch Gen Psychiatry 2011

Prevalence in Adolescent Population

n

Lifetime suicidality was associated with all subtypes of eating disorders

n

Suicidality w as particularly associated w ith BN

u more than half of adolescents with BN reported

suicide ideation and more than a third reported attempts

uSwanson SA et al, Arch Gen Psychiatry 2011

NCAA Study on Athletes and Eating Disorders

n

1,445 student athletes from 11 Division 1 schools

n

Females-mean desired body fat 13% and mean actual body fat 15.4%

u (healthy = 17% - 25%) u Females-173 had BMI 15-20

n

Males-mean desired body fat 8.6% and mean actual body fat 10.5%

u (healthy = 10% - 15%)

n

BN problem s: 9 .2 % ( F) ; .0 1 % ( M)

n

AN problem s: 2 .8 5 % ( F) ; 0 ( M)

Athletes > Non-athletes

n

The “athletic personality”

u Goal orientation, desire for athletic success,

perfectionism, compulsiveness

n

Extreme exercise is risk factor for AN, especially when combined with dieting

slide-16
SLIDE 16

How to Recognize?

n

Look for physical signs:

u Excessive/frequent fluctuations in weight u Stress fractures; overuse injuries u Cramping, weakness, fatigue, achiness u Dizziness, fainting u Broken blood vessels in eyes u Sore throat, swollen salivary glands u Cold intolerance u Constipation u Tooth decay, receding gums

How to Recognize?

n

Look for behavioral signs:

u Restricted food intake; becoming a “picky”

eater

u Eliminating specific foods or whole food groups u Fear of food, avoiding social situations involving

food, solo eating

u Excessive exercise, above expected sport

training

u Regular weighing u Frequent comments about own weight,

calories, food fat content

u Frequent bathroom visits following meals u Moodiness, withdrawal from others

How to Recognize?

n

Look for attitudinal signs:

u Dichotomous thinking

F tendency to only see extremes (good or bad,

black or white, all or nothing)

u Denial of eating problems u Perfectionistic standards u Fear of failure u Harsh self-criticism u Self-worth determined by weight

F Frustration or guilt if unable to control

weight or appearance

Menstrual Dysfunction

  • When you do not eat enough

calories, hormones from the hypothalamus and pituitary will not be released

  • These hormones normally

signal the ovaries to make estrogen and progesterone, and menstrual cycles occur

  • Estrogen is essential for

bones to grow stronger

slide-17
SLIDE 17

n

Amenorrhea- absence of menses > 3 months

u Primary- delay in age of menarche u Secondary- occurs after onset of menarche (most

common, important to rule out pregnancy)

n

Oligomenorrhea- cycles greater than 35 days

n

Anovulation- menses without ovulation

n

Luteal phase suppression

n

Delayed menarche often occurs in athletes

n

Cause of exercise-induced menstrual dysfunction is due to decreased energy input

Menstrual Dysfunction

Incidence of Menstrual Dysfunction in Athletes

n Menarche is significantly delayed in

females who start exercise before onset

  • f menstruation

u These same athletes have increased

incidence of menstrual dysfunction

n Prevalence of 2° amenorrhea in adult

athletes up to 66%

u 2-5% in general population

Incidence of Menstrual Dysfunction in Athletes

n Amenorrhea can be

present in up to 20% of vigorously exercising women

n In some groups up

to 50%

u Professional ballet

dancers

u Elite runners

uEtiology of menstrual

function is:

uMultifactorial uComplex uNot fully understood

slide-18
SLIDE 18

Proposed Influences

  • n Cycle

n Age n Weight n Psychologic stress n Nutritional

inadequacies

n Genetic

predisposition

n Percent body fat n Amount of exercise n Young (< 25 yoa) n Late menarche n Never had children n Vegetarians n Weight loss

associated with training

n Train intensely

More likely to develop Amenorrhea

Energy Drain Hypothesis

n Caloric deficiency

and hypothalamic inhibition

u More prone to stop

  • vulating

u Protective factor to

guard against pregnancy at time

  • f physiological

stress

Energy Drain Hypothesis

n Pulsatile GnRH absent, deficient, or

inappropriately secreted

u Initial trigger may be low amount of

available energy

n Participation in endurance sports increases

hormones (opiods, cortisol, melatonin, dopamine)

u Suppresses frequency and amplitude of

GnRH pulses

Bone Mineral Density

n Peak Bone Mass is achieved between 18-25 yrs

slide-19
SLIDE 19

Determinants of Bone Mineral Density

u Genetics (60-80%) u Exercise and

physical activity

u Hormones u Nutrition u Smoking, drugs

and alcohol

Bone Health Consequences

n

Peak bone mass - 18-25

n

>25, women lose bone mass at 0.3-0.5% annually

n

Lose 2% of BMD per year if amenorrhea or

  • ligomenorrhea

u instead of gaining

typical 2-4% of bone mass

n

Loss of BMD may not be reversible

Effects on Bone Health

n Abnormal or absent menses, with

chronically low ovarian hormones, can lead to decreased BMD

u With chronic amenorrhea (>4 yrs)

reduced bone turnover and reduced bone formation

n Relative risk for stress fractures 2-4x

greater in amenorrheic than eumenorrheic athletes

Effects on Bone Health

n Menstrual history may be more important

than current menstrual status for the prediction of low bone mass

n Even if regain regular menses, BMD in

lumbar spine of previously irregularly menstruating athletes will still be reduced

n Rate of further bone loss retarded, but

bone already lost can’t be replaced

uDrinkwater et al 1990

slide-20
SLIDE 20

Weight-Bearing Exercise and Bone Health

n Protective effect of weight bearing

exercise despite menstrual abnormalities

u Amenorrheic elite runners have greater

vertebral density than amenorrheic sedentary women

n Osteopenia is not confined to only axial

skeleton or trabecular bone

u Can have significantly lower BMD in

proximal femur and femoral mid-shaft

Female Athlete Triad Summary

n

Watch for components of the triad

u low energy

availability (with or without eating disorder)

u menstrual

dysfunction

u altered bone mineral

density

n

Occurs across a spectrum

n

Energy availability is key

n

Menstrual dysfunction more easily detectable

"You don't stop exercising because

you grow old. You grow old because you stop exercising.”

u

  • Anonymous