DA Increases Induced by MP are Markedly Blunted in Cocaine Abusers - - PowerPoint PPT Presentation

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Nov 08, 2022 336 likes •389 views

DA Increases Induced by MP are Markedly Blunted in Cocaine Abusers yet they Triggered Craving 13% Control subjects P <0.001 2 Cocaine abusers P <0.05 DA If DA increases are attenuated why do cocaine abusers have such strong craving?

SLIDE 1

DA Increases Induced by MP are Markedly Blunted in Cocaine Abusers yet they Triggered Craving

2 13%

Control subjects Cocaine abusers

P <0.001 P <0.05

Volkow et al Mol Psychiatry 2014.

If DA increases are attenuated why do cocaine abusers have such strong craving?

SLIDE 2

Viewing A Video Of Cocaine Cues Increased DA In Cocaine Abusers Triggering Drug Craving

Volkow et al J Neuroscience 2006.

% Change Bmax/Kd

Putamen

P < 0.002

0.50

0.0 0.50 1.0 1.5 2.0 2.5

10 20 30

Change in Craving

DA

SLIDE 3

Repeated Drug Use Reduces D2 Receptors

T Y R O S I N E

D A D O P A D A D A D A D A D A

T Y R O S I N E

D A D O P A D A D A D A D A D A

Control Cocaine Abuser Cocaine Alcohol Heroin Meth

control addicted

SLIDE 4

Controls Methamphetamine Abusers

OFC

umol/100gr/min

Controls Alcoholics

control addicted

Brain glucose metabolism

3 4 5 6 7 8 9 2. 9 3 3. 1 3. 2 3. 3 3. 4 3. 5 3. 6

D2 Receptors (BPND)

1.5 2 2.5 3 3.5 22 24 26 28 30 32 34 36 38

(micromol/100g/min)

30 35

1. 8

40 45 50 55 60 65

2 2. 2 2. 4 2. 6 2. 8 3 3. 2 3. 4

Control Cocaine Abuser

DA D2 receptors

Relationship Between Brain Glucose Metabolism and Striatal D2 Receptors

Volkow et al., PNAS 2011.