DA Increases Induced by MP are Markedly Blunted in Cocaine Abusers yet they Triggered Craving 13% Control subjects P <0.001 2 Cocaine abusers P <0.05 DA If DA increases are attenuated why do cocaine abusers have such strong craving? Volkow et al Mol Psychiatry 2014.
Viewing A Video Of Cocaine Cues Increased DA In Cocaine Abusers Triggering Drug Craving Putamen P < 0.002 2.5 Change in Craving 2.0 1.5 1.0 0.50 0.0 -0.50 30 20 10 0 -10 -20 -30 -40 % Change Bmax/Kd DA Volkow et al J Neuroscience 2006.
Repeated Drug Use Reduces D2 Receptors Cocaine Abuser Control Cocaine T Y R O S I N E T Y R O S I N E D O P A D O P A D A D A DA DA D A D A D A D A Meth D A D A D A D A D A D A Alcohol Heroin control addicted
Relationship Between Brain Glucose Metabolism and Striatal D2 Receptors 65 60 Brain glucose metabolism 55 control addicted 50 45 40 Control Cocaine Abuser 35 30 1. 2 2. 2. 2. 2. 3 3. 3. 9 OFC 8 2 4 6 8 2 4 0 8 0 7 0 umol/100gr/min 6 0 5 0 4 Methamphetamine 0 Controls 3 Abusers 2. 3 3. 3. 3. 3. 3. 3. 0 9 1 2 3 4 5 6 4 38 (micromol/100g/min) 36 34 32 30 0 28 26 24 Controls Alcoholics 22 1.5 2 2.5 3 3.5 DA D2 receptors D2 Receptors (BP ND ) Volkow et al., PNAS 2011.
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